Meningoencefalitis amebiana primaria: comunicacion de dos nuevos casos Venezolanos

Petit, Fátima; Vilchez, Varinka; Torres, G.; Molina, Omaira; Dorfman, S; Mora, Eduardo Sosa; Cardozo, José

doi:10.1590/s0004-282x2006000600034

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…To date, reports of the presence of Naegleria from South American countries have relied on the identification of N. fowleri from suspected PAM victims. For instance, two Venezuelan [55] and five Brazilian [30] PAM cases have been registered. One additional Naegleria species has been identified in the public swimming pools of Santiago, Chile [56].…”

Section: Naegleria Spp Diversity In Brazilmentioning

confidence: 99%

Isolation of Naegleria spp. from a Brazilian Water Source

et al. 2020

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The genus Naegleria, of the free-living amoeba (FLA) group, has been investigated mainly due to its human health impact, resulting in deadly infections and their worldwide distribution on freshwater systems. Naegleria fowleri, colloquially known as the “brain-eating amoeba,” is the most studied Naegleria species because it causes primary amoebic meningoencephalitis (PAM) of high lethality. The assessment of FLA biodiversity is fundamental to evaluate the presence of pathogenic species and the possibility of human contamination. However, the knowledge of FLA distribution in Brazil is unknown, and to rectify this situation, we present research on identifying Naegleria spp. in the Monjolinho River as a model study. The river is a public Brazilian freshwater source that crosses the city of São Carlos, in São Paulo state, Brazil. Five distinct sampling sites were examined through limnological features, trophozoites culturing, and PCR against internal transcribed spacer (ITS) regions and 5.8S rRNA sequences. The results identified N. philippinensis, N. canariensisi, N. australiensis, N. gruberi, N. dobsoni sequences, as well as a Hartmannella sequence. The methodology delineated here represents the first Brazilian Naegleria spp. study on a freshwater system. Our results stress the urgency of a large scale evaluation of the presence of free-living amoebas in Brazil.

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Section: Naegleria Spp Diversity In Brazilmentioning

confidence: 99%

Isolation of Naegleria spp. from a Brazilian Water Source

et al. 2020

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“…To date, Naegleria reports from South America countries have relied on N. fowleri identification aimed on diagnosis of samples obtained from PAM suspect victims. For instance, two Venezuelan [52] and five Brazilian [29] PAM cases have been registered. Regarding environmental isolations in this area, it has been conducted generally at genus level without assessing the diversity at the species level, as reports of Naegleria presence in public swimming pools of Santiago, Chile [53].…”

Section: Naegleria Spp Diversity In Brazilmentioning

confidence: 99%

Isolation of <em>Naegleria spp.</em> from a Brazilian Water Source

Bellini¹,

Fonseca²,

Reyes-Batllé³

et al. 2019

Preprint

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The genus Naegleria, of free-living amoeba (FLA) group, has been investigated mainly due to its human health impact resulting in deadly infections and their worldwide distribution on freshwater systems. Naegleria fowleri, colloquially known as the “brain-eating amoeba”, is the most studied Naegleria species because it causes Primary Amoebic Meningoencephalitis (PAM) of high lethality. The assessment of FLA biodiversity is fundamental to evaluate the presence of pathogenic species and the possibility of human contamination. However, the knowledge of FLA distribution in Brazil is unknown, and to rectify this situation we present a research on identifying Naegleria spp. in the Monjolinho River, as a model study. The river is a public Brazilian freshwater source that crosses the city of São Carlos. Five distinct sampling sites were examined through limnological features, trophozoites culturing and PCR against internal transcribed spacers (ITS) regions and 5.8S rRNA sequence. The results identified N. philippinensis, N. canariensisi, N. australiensis, N.gruberi, N. dobsoni sequences, as well as a Vahlkampfia sequence. The methodology delineated here represents the first Brazilian Naegleria spp. study on a freshwater system. Our result stresses the urgency of a large scale evaluation of the presence of free-living amoebas in Brazil.

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“…These are not infections strictly requiring epidemiological reporting so their true frequency is unknown. Infections due to FLA are associated to a 95% mortality, compounded perhaps by untimely diagnoses and the lack of appropriate and effective treatment (Peralta-Rodríguez and Ayala-Oviedo, 2009;Oddó, 2006;Petit et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Free-living amoebae that are pathogenic to man have been identified in the water of swimming pools as well as natural recreation waters in several parts of the world, that are now considered as dangerous contact sources (Ávila et al, 2006;Petit et al, 2006;Muñoz et al, 2003;Sánchez-Lihon et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Free-Living Amoebae and Central Nervous System Infection: Report of Seven Cases

Enrique¹,

Verónica²,

Nibardo³

et al. 2019

American Journal of Infectious Diseases

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The Free-Living Amoeba (FLA) is an opportunistic protozoan with a cosmopolitan distribution that can cause Central Nervous System (CNS) infection. It develops in relatively stagnant waters such as swimming pools, lagoons and ponds but only species belonging to the genera Hartmannella, Naegleria, Acanthamoeba and Balamuthia have been found in humans. The resulting pathology is highly lethal due to the lack of effective treatment. The aim of this study is to describe a series of neuroinfection cases treated at the Hospital de Infectología in Mexico City. This is a descriptive study conducted between July 2008 and June 2016. It includes all patients admitted with signs and symptoms of meningoencephalitis and a laboratory work-up confirming the presence of FLA trophozoites in Cerebrospinal Fluid (CSF). Statistical Analysis. Nominal variables are reported as relative frequencies and quantitative variables, as medians, maximum and minimum. Seven cases were identified, 43% of which were male. The median number of days between exposure and symptom development was nine days. The most frequent symptoms were: Headache 57%, vomiting 29%, fever 57%, meningeal irritation 43% and altered consciousness 86%. Three of the seven analyzed cases died and one case was also HIV positive. It is important to consider this presumptive diagnosis in order to search for FLA in tissues or CSF and obtain cultures in selected media. Mortality is high, particularly when the brain is compromised.

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Meningoencefalitis amebiana primaria: comunicacion de dos nuevos casos Venezolanos

Cited by 9 publications

References 12 publications

Isolation of Naegleria spp. from a Brazilian Water Source

Isolation of Naegleria spp. from a Brazilian Water Source

Isolation of <em>Naegleria spp.</em> from a Brazilian Water Source

Free-Living Amoebae and Central Nervous System Infection: Report of Seven Cases

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