Does treatment with N-butyl cyanoacrylate embolization protect against hemorrhage in cerebral arteriovenous malformations?

Raupp, Eduardo; Fernandes, Jefferson Gomes

doi:10.1590/s0004-282x2005000100007

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…On the other hand, pre-operative embolization using NBCA requires obliteration of at least two-thirds or more volume of the nidus to be effective in brain AVM surgery ( 24 ). Multiple embolization sessions are mandatory when using NBCA, especially for large brain AVMs, to achieve adequate nidus obliteration in radiation exposure and hemodynamic safety.…”

Section: Discussionmentioning

confidence: 99%

Impact of Pre-operative Embolization With Onyx for Brain Arteriovenous Malformation Surgery

et al. 2022

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ObjectiveTo clarify the safety and efficacy of pre-operative embolization using Onyx liquid embolic agent (Onyx; ev3) compared with N-butyl cyanoacrylate (NBCA; Cordis Neurovascular, Inc.) or coils in cerebral arteriovenous malformation (AVM) surgery.MethodsThis was a retrospective review of a prospectively collected clinical database of brain AVMs treated at our institute from January 2005 to March 2021. A total of 38 consecutive patients who underwent AVM resection after pre-operative embolization were included. Based on pre-operative embolization materials, the patients were divided into the pre-Onyx group (n = 16), in which NBCA or coils were used for embolization, and the Onyx group (n = 22). Patient characteristics and treatment results were compared between the two groups.ResultsPatient characteristics were comparable between the two groups in terms of age, sex, and rupture status. While the Spetzler–Martin grade was also similar between the two groups, the location of the AVM nidus in the eloquent area was slightly higher in patients in the Onyx group (72.7%) than in patients in the pre-Onyx group (43.8%) (P = 0.09). The embolization rate was higher in the pre-Onyx group (mean: 63.0%; range: 12.7–100%) than in the Onyx group (mean: 50.0%; range: 15.8–100%), but the difference was not statistically significant (P = 0.06). The time needed for surgical removal was shorter in the Onyx group (mean: 354.8 min; range: 144–884 min) than in the pre-Onyx group (mean: 457.9 min; range: 240–1,294 min); however, this difference was not statistically significant (P = 0.13). The amount of intraoperative bleeding was significantly lower in the Onyx group (mean: 129.8 ml; range: 20–540 mL) than in the pre-Onyx group (mean: 448.8 mL; range: 120–1,550 ml) (P = 0.0008). The surgical complication rates were comparable between the two groups (pre-Onyx group, 18.8%; Onyx group, 4.5%; P = 0.29).ConclusionsPre-operative embolization with Onyx can significantly reduce the amount of intraoperative bleeding in AVM resection and may contribute to safe AVM surgery.

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Section: Discussionmentioning

confidence: 99%

Impact of Pre-operative Embolization With Onyx for Brain Arteriovenous Malformation Surgery

et al. 2022

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“…Rebleeding rate after embolization varies from 2.0% to 8.7% and the volume reduction less than two third or 90% was pointed as a cause of rebleeding 33,36,77,102) . But these reports were based on the nBCA experiences, and the Onyx is expected to decrease rebleeding.…”

Section: Cerebral Arteriovenous Malformationsmentioning

confidence: 97%

Current Status and Future Prospect of Endovascular Neurosurgery

Jeon

Kwon

2008

J Korean Neurosurg Soc

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“…108 A less speci fi c treatment regimen had patients with a 5.4% annual risk of bleeding and 1% risk of dying after embolization. 58 A lesser degree of occlusion and whether the patient had bled prior to the procedure were the main determinants of whether the patient haemorrhaged in the follow-up.…”

Section: Endovascular Techniquementioning

confidence: 99%