Inhibition of peridural fibrosis after laminectomy using biological sheet in rat model

Herculano, Marco Antonio

doi:10.1590/s0004-282x2004000600037

Cited by 1 publication

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“…These barriers impede the migration of the fibroblasts from the musculature to the neural and the paraneural structures. With this aim, many materials have been employed, with biological capacity or inert, resorbable or nonresorbable, solid or fluid, but none have been found to be entirely effective [5,7,10,12,14,15,24,26]. Recently, an expandable polytetrafluroethylene membrane (ePTFE) [7] and an ADCON-L (bioresorbable gelatin and polyglycan gel) [10] have been recommended.…”

Section: Discussionmentioning

confidence: 99%

Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs

Sandoval

Hernández-Vaquero

2008

Eur Spine J

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Peridural fibrosis is one of the more frequent complications of lumbar surgery. Nonsteroidal antiinflammatory drugs inhibit the inflammatory and fibroblastic response. We performed lumbar laminectomies in 24 rabbits, divided into two groups. The experimental group received 5 mg/kg/day of aceclofenac for 7 days and the control group received 1 cm 3 of physiological saline. The samples were stained using immunohistochemical methods. The cellular populations in the inflammatory reaction and the thickness of the fibrous membrane were quantified. The mean of the fibrous area was always less in the rabbits of the experimental group compared to controls (47% less at 2 weeks and 41% less at 4 weeks). We observed an 8% decrease in the number of fibroblasts with antivimentin monoclonal antibodies in the experimental group. In this model, aceclofenac inhibits the presence of inflammatory cells in the fibrous scar in the early stages and reduces the extension of adhesions without adverse reactions.

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