Analysis of parahippocampal gyrus in 115 patients with hippocampal sclerosis

Ferreira, Nelson Fortes; Oliveira, Vanessa de; Amaral, Lázaro Luís Faria do; Mendonça, Renato Adam; Lima, Swiany Silveira

doi:10.1590/s0004-282x2003000500001

Cited by 17 publications

(13 citation statements)

References 5 publications

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“…Previous studies that have used volumetric region of interest measures in TLE have reported atrophy in extrahippocampal regions of the medial temporal lobe [2,9,12], in the thalamus [34], the entorhinal cortex [6,30], the amygdala [16], the lateral temporal lobe [32] and the cerebellum [40] and throughout other regions of the limbic system [35]. Studies using VBM of the entire brain have confirmed these observations [23] and suggested that hippocampal pathology in TLE is accompanied by widespread limbic pathology.…”

Section: Discussionmentioning

confidence: 87%

“…Studies that have used volumetric ROI measures in TLE have reported atrophy not only in the hippocampus but also in the thalamus [34], the cerebellum [40] as well as in extrahippocampal regions of the medial temporal lobe [2,9,12] such as the entorhinal cortex [6,30], the amygdala [16], the lateral temporal lobe [32]. Indeed, in TLE patients with MRI detectable medial temporal sclerosis, atrophy and/or signal change have been reported ■ Abstract Hippocampal sclerosis in temporal lobe epilepsy (TLE) is often associated with hippocampal atrophy.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy

et al. 2005

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Hippocampal sclerosis in temporal lobe epilepsy (TLE) is often associated with hippocampal atrophy. This study assessed whether such atrophy is correlated with loss of gray matter volume in other brain regions. In 16 patients with TLE and clear magnetic resonance imaging-based evidence of hippocampal sclerosis, hippocampal volumes were determined manually and the local gray matter (LGM) amount was estimated throughout the entire brain using voxel-based morphometry. Voxelwise correlations between the volume of the sclerotic hippocampus and LGM were computed. The pattern of voxels whose LGM correlated with hippocampal volume outlined remarkably well the anatomy of the extended limbic system and included the parahippocampal region, cingulate gyrus throughout its extent, basal forebrain, thalamic nuclei, medial orbitofrontal areas and the insula. These correlations emerged mainly on the side ipsilateral to the affected hippocampus but were also found contralaterally. No such correlations were found in a group of 16 healthy controls. The present data show that hippocampal volume loss in TLE is associated with a widespread limbic systems atrophy. These findings are helpful to better understand the functional deficit and reorganization often found in temporal lobe epilepsy and will also provide a basis to assess neural plasticity in the limbic system for those patients who will undergo curative temporal lobe surgery.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy

et al. 2005

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“…The key role of this region is memory encoding and retrieval. Abnormalities may indicate underlying conditions, such as schizophrenia, Alzheimer’s disease, and hippocampal sclerosis (Ferreira et al, 2003 ). The observation of hyper-activation in the parahippocampal gyrus is consistent with the finding of Dr Maki leading investigators that women receiving HT exhibit decreased regional cerebral blood flow in the right precuneus, the dorsal frontal gyrus, and the parahippocampal gyrus during a verbal memory task (Resnick et al, 1998 ).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Neuroactivation during Working Memory Task in Postmenopausal Women Receiving Hormone Therapy: A Coordinate-Based Meta-Analysis

Huang

Han

et al. 2015

Front. Hum. Neurosci.

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Background and Aim: Hormone therapy (HT) has long been thought beneficial for controlling menopausal symptoms and human cognition. Studies have suggested that HT has a positive association with working memory, but no consistent relationship between HT and neural activity has been shown in any cognitive domain. The purpose of this meta-analysis was to assess the convergence of findings from published randomized control trials studies that examined brain activation changes in postmenopausal women.Methods: A systematic search for fMRI studies of neural responses during working memory tasks in postmenopausal women was performed. Studies were excluded if they were not treatment studies and did not contain placebo or blank controls. For the purpose of the meta-analysis, 8 studies were identified, with 103 postmenopausal women taking HT and 109 controls.Results: Compared with controls, postmenopausal women who took HT increased activation in the left frontal lobe, including superior frontal gyrus (BA 8), right middle frontal gyrus (BA 9), anterior lobe, paracentral lobule (BA 7), limbic lobe, and anterior cingulate (BA 32). Additionally, decreased activation is noted in the right limbic lobe, including parahippocampal gyrus (BA 28), left parietal lobe, and superior parietal lobule (BA 7). All regions were significant at p ≤ 0.05 with correction for multiple comparisons.Conclusion: Hormone treatment is associated with BOLD signal activation in key anatomical areas during fMRI working memory tasks in healthy hormone-treated postmenopausal women. A positive correlation between activation and task performance suggests that hormone use may benefit working memory.

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“…tarafından, hipokampal atrofisi olan 115 hastanın %37'sinde ipsilateral parahipokampal girus (PHG) atrofisi görülebileceği bildirilmiştir. 26 Yine bilateral talamus volumlerinin incelendiği iki ayrı çalışmada, sklerotik hipokampusun ipsilateralindeki talamik yapılarda hücresel kayıp ve atrofi ile uyumlu bulgular elde edilmiş-tir. 27,28 Çalışmamızda da, her iki hasta grubunda ipsilateral amigdala, PHG ve talamus volumlerinin kontrol grubuna göre anlamlı düzeyde düşük olduğu izlendi.…”

Section: Discussionunclassified

“…Çalışmamıza benzer bir şekilde MTLE-HS tanısı alan hastaların MRV ile değerlen-dirildiği bir çalışmada, 20 yıldan daha uzun süreli hastalık öyküsü olan bireylerde PHG volumlerinin anlamlı derecede düşük olduğu saptanmış, ve bu nedenle MTLE-HS saptanan kişilerde PHG alanı-nın da incelenmesi gerektiği ileri sürülmüştür. 26 Çalışmamızda artmış nöbet sıklığı ile sol amigdala volumü arasında negatif yönde korelasyon saptandı. Amigdala volumü ve nöbet özellikleri arasındaki ilişki konusunda literatürde farklı sonuçlar mevcuttur.…”

Section: Fk (+) (N=12) Fk (-) (N=16) Punclassified

The Relationship Between Volumetric Changes of Hippocampal and Extrahippocampal Areas and Etiological and Clinical Factors in Patients with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Basaran¹,

Kutlu²,

Anık³

et al. 2014

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, hipokampal skleroza bağlı mesial temporal lob epilepsili (MTLE-HS) hastalarda hipokampal ve ekstrahipokampal alanları manyetik rezonans volumetri (MRV) yöntemiyle incelemek ve volumetrik değişikliklerin etiyolojik ve klinik faktörlerle ilişkisini araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 14 sol ve 14 sağ MTLE-HS'li 28 hasta ve 36 sağlıklı kontrol olmak üzere, toplam 64 kişi dâhil edildi. Üç grup arasında hipokampus, amigdala, parahipokampal girus (PHG), talamus, serebellum volumleri ve korpus kallozum (KK) volumü karşılaştırıldı. Hasta grubundaki volumetrik ölçümler, etiyolojik nedenler ve klinik faktörlere göre karşılaştırılarak incelendi. B Bu ul lg gu ul la ar r: : Çalışmamızda bilateral hipokampus, amigdala, PHG ve talamus volumlerinin 3 grup arasında anlamlı düzeyde farklılık gösterdiği belirlendi. Serebellum volumleri ve KK volumü arasında ise 3 grup arasında istatistiksel olarak anlamlı farklılık mevcut değildi. Hem sağ hem de sol MTLE'li hastalarda ipsilateral hipokampus, amigdala, PHG ve talamus volumlerinin kontrol grubuna göre anlamlı oranda düşük olduğu saptandı. Hasta grubunda, febril konvulsiyon öyküsü olanlarda sol hipokampus ve bilateral talamus volumleri anlamlı olarak daha düşük saptandı. Nöbet sıklığı ile sol hipokampus, sol amigdala ve sol serebellum volumleri ile arasında negatif yönde korelasyon saptanırken, hastalık süresi ile sol PHG ve sol talamus volumleri arasında negatif yönde korelasyon izlendi. S So on nu uç ç: : MTLE-HS'li hastalarda atrofik değişiklikler yalnızca hipokampusa sınırlı olmayıp, parahipokampal ve ekstrahipokampal alanlarda da görülebilir. Febril konvulsiyon öyküsü, artmış nöbet sıklığı ve uzamış hastalık süresi bu değişiklikler ile ilişkili olabilir.A An na ah ht ta ar r K Ke el li im me el le er r: : Epilepsi, temporal lob; hipokampus; manyetik rezonans görüntüleme; risk faktörleri A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate the volumetric changes in hippocampal and extrahippocampal regions by using magnetic resonance volumetry (MRV), and to explore the relation between these volumetric changes and etiological and clinical factors among patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study group consisted of 64 subjects [28 patients (14 right, 14 left MTLE-HS) and 36 healthy controls]. Hippocampus, amygdala, parahippocampal gyrus (PHG), thalamus, cerebellum and corpus callosum (CC) volumes were compared among and within three groups. Volumetric measurements were investigated according to the comparison of etiological and clinical factors in the patient group. R Re es su ul lt ts s: : Bilateral hippocampus, amygdala, parahippocampal gyrus and thalamus volumes were significantly different whereas corpus callosum and cerebellar volumes were not significantly different among three groups. In the comparison of volumetric changes within each group, ipsilateral hipp...

show abstract

Analysis of parahippocampal gyrus in 115 patients with hippocampal sclerosis

Cited by 17 publications

References 5 publications

Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy

Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy

Enhanced Neuroactivation during Working Memory Task in Postmenopausal Women Receiving Hormone Therapy: A Coordinate-Based Meta-Analysis

The Relationship Between Volumetric Changes of Hippocampal and Extrahippocampal Areas and Etiological and Clinical Factors in Patients with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

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