Metástases intrarraquidianas de glioblastoma multiforme supratentorial da infância: relato de caso

Abstract

RESUMO -Relatamos o caso de uma menina de onze anos de idade com glioblastoma multiforme na região têmporo-parietal direita, completamente ressecado cirurgicamente, submetida a radioterapia craniana pós-operatória. Houve recaída três meses após, em topografia distante do sítio primário, na porção caudal do canal raquidiano. Após, ocorreu evolução rápida para o óbito. A propósito desse caso, discutimos nossa experiência quanto à conduta nesses tumores e a literatura sobre o assunto. PALAVRAS-CHAVE: glioblastoma multiforme, metástase intrarraquidiana.Spinal cord metastatic glioblastoma multiforme of childhood: case report Spinal cord metastatic glioblastoma multiforme of childhood: case report Spinal cord metastatic glioblastoma multiforme of childhood: case report Spinal cord metastatic glioblastoma multiforme of childhood: case report Spinal cord metastatic glioblastoma multiforme of childhood: case report ABSTRACT -We report the case of an eleven years-old girl with a right temporo-parietal glioblastoma multiforme. The tumor was totally resected on neurossurgery, and cranial radioteraphy was applied at next. The tumor recurred three months later, far from primary site, in the caudal portion of the spinal canal. Death occurred in less than one month later. Taking into account the data of this case, we discuss our experience in the management of such tumors and the literature on the subject. KEY WORDS: glioblastoma multiforme, spinal metastasis.

Glioblastoma multiforme in childhood: a case report

“…Seizures may herald the onset, especially when tumors are close to the cerebral cortex. Other common clinical manifestations include hemiparesis, visual deficit, headache, and, in some cases, signs of intracranial hypertension due to an obstruction of the CSF pathways 2-8. In our case, the first clinical manifestation was hemiparesis and clouding of the consciousness, with rapidly evolving intracranial hypertension despite partial removal of the tumor.…”

“…Gliomas constitute approximately 60% of all cerebral tumors, and approximately half of them are considered to be high-grade malignant tumors 1. The prognosis for recovery is conservative, and 5-year survival rates range from 5% to 15% 2,6,7. This case report documents a GBM that was located deep in the right cerebral hemisphere of a 9-year-old child.…”

“…Males are slightly more affected than females (male:female ratio  =  1.5:1). In terms of histology, anaplastic astrocytomas are characterized by hypercellularity, nuclear atypia, mytotic figures, nuclear pleomorphism and vascular proliferation; GBM also has associated necrosis 2,6. …”

Symptomatic spinal cord metastasis of glioblastoma multiforme

“…In brazilian literature there are very few publications concerning spinal cord metastatic glioblastoma multiforme. We only found a single case describing an eleven years-old girl with a right temporo-parietal glioblastoma multiforme with metastasis to the caudal portion of the spinal canal after cranial resection and radiotherapy 7 . Another case reported a lumbar vertebral metastasis presenting with back pain in a patient harboring a right cerebral glioblastoma 9 .…”

Symptomatic spinal cord metastasis of glioblastoma multiforme

“…In brazilian literature there are very few publications concerning spinal cord metastatic glioblastoma multiforme. We only found a single case describing an eleven years-old girl with a right temporo-parietal glioblastoma multiforme that metastasised to the caudal portion of the spinal canal after cranial resection and radiotherapy 7 . Another case reported a lumbar vertebral metastasis presented with back pain in a patient harboring a right cerebral glioblastoma 9 .…”