Complete remission of epileptic psychosis after temporal lobectomy: case report

Marchetti, R.; Tavares, Alexandre Garcia; Gronich, Gary; Fiore, Lia Arno; Ferraz, Renata Barbosa

doi:10.1590/s0004-282x2001000500028

Cited by 19 publications

(8 citation statements)

References 39 publications

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“…Conversely, temporal lobectomy (resection of the hippocampus — and presumably removal of the focus of over-activation) resulted in a recovery from psychosis in a patient with temporal lobe epilepsy (Marchetti et al 2001). …”

Section: Methodsmentioning

confidence: 99%

A Cognitive Neuroscience View of Schizophrenic Symptoms: Abnormal Activation of a System for Social Perception and Communication

Wible

Preus

Hashimoto

2008

Brain Imaging and Behavior

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We will review converging evidence that language related symptoms of the schizophrenic syndrome such as auditory verbal hallucinations arise at least in part from processing abnormalities in posterior language regions. These language regions are either adjacent to or overlapping with regions in the (posterior) temporal cortex and temporo-parietal occipital junction that are part of a system for processing social cognition, emotion, and self representation or agency. The inferior parietal and posterior superior temporal regions contain multi-modal representational systems that may also provide rapid feedback and feed-forward activation to unimodal regions such as auditory cortex. We propose that the over-activation of these regions could not only result in erroneous activation of semantic and speech (auditory word) representations, resulting in thought disorder and voice hallucinations, but could also result in many of the other symptoms of schizophrenia. These regions are also part of the so-called “default network”, a network of regions that are normally active; and their activity is also correlated with activity within the hippocampal system.

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Section: Methodsmentioning

confidence: 99%

A Cognitive Neuroscience View of Schizophrenic Symptoms: Abnormal Activation of a System for Social Perception and Communication

Wible

Preus

Hashimoto

2008

Brain Imaging and Behavior

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“…25 Remission of IPE and PIPE has been reported after epilepsy surgery in a woman who had suffered from TLE since the age of 15 years. 36 She developed recurrent PIPE at the age of 35, and this evolved to chronic refractory IPE. The presurgical evaluation demonstrated right hippocampal atrophy and a right mesial temporal epileptogenic focus.…”

Section: Postictal Psychotic Episodesmentioning

confidence: 99%

Psychosis of epilepsy: a multifaceted neuropsychiatric disorder

Kanner

Rivas-Grajales

2016

CNS Spectr.

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Psychosis of epilepsy (POE) is a term applied to a group of psychotic disorders with a distinct phenomenology in which potential etiopathogenic mechanisms are believed to be closely related to a seizure disorder. POE can present as interictal psychotic episodes, which may often differ semiologically from primary schizophrenic disorder. They may present as ictal or postictal psychotic episodes and may be the expression of an iatrogenic process to pharmacologic and/or surgical interventions.Epilepsy and POE have a complex and bidirectional relation, as not only are patients with epilepsy at greater risk of developing a psychotic disorder, but patients with a primary psychotic disorder are also at greater risk of developing epilepsy. The prevalence of POE is more than 7 times higher than the frequency of primary schizophreniform disorders in the general population. While POE has been associated with focal epilepsy of temporal and frontal lobe origin, its etiology and pathophysiology of POE have yet to be established.The treatment of all forms of POE, with the exception of ictal psychotic episodes, requires the use of antipsychotic drugs, preferably the atypical antipsychotic agents with a very low or negligible potential to lower the seizure threshold (eg, risperidone, apiprazole), starting at a low dose with stepwise increments.

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“…It should be noted that there is at least one reported case of a patient being cured of both epilepsy and psychosis with right temporal lobe resection [142]. …”

Section: Future Directionsmentioning

confidence: 99%