Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis

Santos, Isabel Cristina dos; Kobayashi, Eliane; Cardoso, Tânia Marchiori; Guerreiro, Carlos A. M.; Cendes, Fernando

doi:10.1590/s0004-282x2000000600006

Cited by 11 publications

(6 citation statements)

References 33 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To resolve this issue, numerous trials to assess the efficacy of cysticidal drugs had been carried out in the last two decades, [11,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] but these did not definitively solve the issue. A few trials, largely in children, have focused on the efficacy of cysticidal drugs in SCCL [11,15,19,20,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: Effect on long-term seizure outcome

Souza¹,

Thennarasu²,

Yeshraj³

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: Effect on long-term seizure outcome

Souza¹,

Thennarasu²,

Yeshraj³

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…The CSF may be normal or show only mild protein elevation, but pleocytosis with presence of eosinophilus and a positive ELISA or immunofluorescence test is commonly observed [1][2][3] . The treatment with cysticids (albendazole or praziquantel) in most patients accelerate the degeneration of cysts and improve clinical symptoms 3,4 , but this remains controversial 1 . Neurocysticercosis and seizures are common and its relationship is more clearly identified in patients with adult onset partial seizures, frequently associated to headache or focal neurological deficits.…”

mentioning

confidence: 99%

“…Neurocysticercosis and seizures are common and its relationship is more clearly identified in patients with adult onset partial seizures, frequently associated to headache or focal neurological deficits. The correlation between cyst localization and seizure semiology is variable, as well as the correlation between number of cysts and seizure frequency 2,4,5 . The recent advances on neuroimaging have provided means for better evaluating patients with epilepsy, particularly those with refractory seizures or suspected structural abnormalities.…”

mentioning

confidence: 99%

Late onset temporal lobe epilepsy with MRI evidence of mesial temporal sclerosis following acute neurocysticercosis: case report

Kobayashi

Guerreiro

Cendes

2001

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

-The objective of this case report is to describe magnetic resonance imaging (MRI) evidence of mesial temporal sclerosis (MTS) in a patient with new onset temporal lobe epilepsy (TLE) and acute neurocysticercosis with multiple cysts. A 56 years old man with new onset headache, Simple Partial Seizures and Complex Partial Seizures underwent CT scan and lumbar puncture as diagnose proceeding. Multiple cysts and meningitis were identified, with a positive immunology for cysticercosis. Seizures were recorded over the left temporal region in a routine EEG. Treatment with albendazole was performed for 21 days, with clinical improvement and seizure remission after 4 months. An MRI scan 11 months after treatment, showed complete resolution of those cystic lesions and a left hippocampal atrophy (HA) with hyperintense T2 signal. The presence of HA and hyperintense T2 signal in this patient has not, to date, been associated with a poor seizure control.Conclusions: This patient presented with MRI evidence of left MTS after new onset partial seizures of left temporal lobe origin. Although we did not have a previous MRI scan, it is likely that this hippocampal abnormality was due to the acute inflammatory response to cysticercosis associated to repeated partial seizures. This suggests that acute neurocysticercosis associated with repeated seizures may cause MTS and late onset TLE.KEY WORDS: temporal lobe epilepsy, hippocampal atrophy, mesial temporal sclerosis, acute neurocysticercosis. Epilepsia de lobo temporal de início tardio com evidências de esclerose mesial temporal após quadro agudo de neurocisticercose: relato de casoRESUMO -O objetivo deste relato é descrever a evidência de esclerose mesial temporal (EMT) por ressonância magnética (RM) em um paciente com epilepsia de lobo temporal (ELT) de início tardio e múltiplos cisticercos. Um paciente de 56 anos previamente hígido, iniciou quadro de cefaléia, crises parciais simples e complexas, sendo realizadas TC de crânio e punção lombar. Foram visualizados múltiplos cistos e meningite com imunologia positiva para cisticercose. Registramos crises com início em região temporal esquerda durante um eletroencefalograma de rotina. Iniciamos tratamento com albendazol, por 21 dias, e observamos melhora clínica e remissão de crises após 4 meses. RM feita 11 meses após o tratamento mostrou resolução completa das lesões císticas e uma atrofia hipocampal (AH) esquerda com hipersinal em T2. A presença de AH com hipersinal em T2 neste paciente não está até o momento associada com crises refratárias. Conclusões: Apesar de não dispormos de RM previamente ao início do quadro clínico, é provável que esta alteração hipocampal seja decorrente da resposta inflamatória aos cisticercos associadamente às crises parciais repetidas. Isto sugere que formas agudas de neurocisticercose associadas a crises repetidas possam causar EMT e ELT de início tardio.PALAVRAS-CHAVE: epilepsia de lobo temporal, atrofia hipocampal, esclerose mesial temporal, neurocisticercose aguda.

show abstract

“…Persistent headache, vomiting and focal neurologic deficit were probably due to residual cysts acting as space occupying lesions, whereas persistent calcified lesions were responsible for seizures. Opinions also vary on the use of anticonvulsants for control of seizures and the probability of seizure-free period after discontinuation of these drugs [13][14][15]. In the present study, carbamazepine was used for 6 months in all barring those showing toxicity, in whom phenytoin was added.…”

Section: Discussionmentioning

confidence: 92%

“…Background abnormality was marginally more common than focal discharges. Santos et al [13] had found EEG abnormality in 62% of cases with 28% showing relationship between focal EEG abnormality and location of cyst. In the present study, similar results were observed but higher percent-age (45.9%) was noted.…”

Section: Discussionmentioning

confidence: 98%

Clinical profile and outcome of pediatric neurocysticercosis: A study from Western Nepal

2015

View full text Add to dashboard Cite

Neurocysticercosis (NCC) is a very common pediatric neurological problem in Western Nepal. Its magnitude is not adequately known as in most situations it remains as an iceberg. To define the problem a retrospective study of the clinical profile, response to treatment and follow-up of the pediatric cases was done. Hospital records of inpatients admitted in the last 4 years (2000?2003) with the diagnosis of NCC were reviewed. Diagnosis was primarily based on clinical features, computed tomography (CT) scan features and exclusion of other causes. All patients were treated with 28 days? course of albendazole, anti-edema drugs and anticonvulsants. Follow-up period varied from 1 to 3 years. The medical records of 124 children with NCC were evaluated. The most common age group affected was 10?12 years with the youngest patient of 11 months. Partial seizure was the most prominent presentation. The most frequent finding in CT scan was single ring-enhancing lesion with perilesional edema affecting the parietal lobe. Twenty patients were lost to follow up. Ninety-eight patients had complete clinical response and 87 of them had complete disappearance of lesion in CT scan at the end of 1 year. Recurrence of seizure was the only residual symptom found in six (4.8% patients, all of them having calcified lesions in CT scan. In areas where NCC is endemic, partial seizure in the pediatric age group is highly suggestive and should be considered as a potential indicator of the disease. Considering the lower cost and easy availability, CT scan remains the best investigation for confirmation of diagnosis in a developing country like Nepal. The disease is usually completely curable. Recurrent partial seizure is the only residual symptom, which may occur more commonly in patients with calcified lesions.

show abstract

Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis

Cited by 11 publications

References 33 publications

Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: Effect on long-term seizure outcome

Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: Effect on long-term seizure outcome

Late onset temporal lobe epilepsy with MRI evidence of mesial temporal sclerosis following acute neurocysticercosis: case report

Clinical profile and outcome of pediatric neurocysticercosis: A study from Western Nepal

Contact Info

Product

Resources

About