Nervous system cancer mortality in an industrialized area of Brazil 1980 - 1993

Abstract

-Objectives:The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil. Method: From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated comparing the standardized mortality rate for ages over 10 years old (G1) and for the age group from 35 to 64 years old, in the industrialized and non-industrialized areas in three periods : 1980-1993, 1980-86, 1987-93. Results: A statiscally significant high mortality was observed in the industrialized area, for ages over 10 in all periods and only from 1980 to 1993 for ages from 34 to 64. The highest mortality ratio occurred from 1980-86 for ages over 10 -4.12 (CI 1.79-9.42). Conclusion: High mortality was probably related to the environmental and occupational exposure to many organic and inorganic chemical substances, considered carcinogenics, such as aliphatic and aromatic hydrocarbons, organochlorinated, formaldehyde, nitrogenated compounds and heavy metals, found in the port and industrial complex. We discuss the importance of case-control studies in characterizing the association of these and other risk factors in the determination of NSC.KEY WORDS: occupational cancer, cancer mortality, cancer epidemiology, nervous system cancer; brain cancer. Mortalidade por câncer do sistema nervoso em uma área industrializada do Brasil 1980-1993RESUMO -Objetivo: Estudar o processo de industrialização e a mortalidade por câncer do sistema nervoso (CSN) em uma região urbana do Brasil. Método: Foram selecionados dos registros das Fundação Sistema Estadual de Análise de Dados Estatísticos (SEADE), 103 óbitos por CSN (ICD-9) ocorridos na Baixada Santista, no sexo masculino acima dos 10 anos, de 1980 a 1993. Calcularam-se as razões de mortalidade, padronizadas por idade, comparando as áreas industrializada e não industrializada, nos períodos de 1980-93, 1980-96 e 1987-93. Resultados: Observou-se excesso significante de mortalidade na área industrializada para a população acima de 10 anos, em todos os períodos -3.11 ) e 2.63 . Para o grupo de 35-64 anos o excesso ocorreu apenas no período de 1980-93 -2.46 (CI 1.20-5.11). Conclusão: Supõe-se que esse excesso relaciona-se à exposição ocupacional e ambiental a carcinogênicos presentes no complexo industrialportuário como: hidrocarbonetos aromáticos, órgano-clorados, compostos nitrogenados e metais. Estudos casocontrole são necessários para o estudo desses e de outros fatores de risco na determinação do CSN. PALAVRAS-CHAVE: câncer ocupacional, mortalidade por câncer, epidemiologia do câncer, câncer do sistema nervoso.

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