Neuroparacoccidioidomycosis: critical analysis of 33 cases

Neto, Antonio Morato Leite

doi:10.1590/s0004-282x1995000100031

Arq. Neuro-Psiquiatr.

1995

DOI: 10.1590/s0004-282x1995000100031

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Neuroparacoccidioidomycosis: critical analysis of 33 cases

Antonio Morato Leite Neto¹

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Meningite paracoccidioidomicótica: relato de caso

Lorenzoni

Chang

Paniago

et al. 2002

Arq. Neuro-Psiquiatr.

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RESUMO -O envolvimento do sistema nervoso central na paracoccidioidomicose tem sido pouco descrito na literatura, sendo rara sua apresentação sob a forma meníngea. Descreve-se o caso de um paciente de 23 anos que desenvolveu meningite paracoccidioidomicótica comprovada pela positividade do fungo na pesquisa direta e cultura do líquido cefaloraquidiano. Discute-se a apresentação da forma meníngea da paracoccidioidomicose, seu diagnóstico laboratorial e neurorradiológico. Destaca-se a importância da investigação rotineira do fungo.PALAVRAS-CHAVE: paracoccidioidomicose, sistema nervoso central, meningite. Paracoccidioidomycosis meningitis: case reportABSTRACT -The involvement of the central nervous system in paracoccidioidomycosis and its meningeal form of clinical presentation have rarely been described. This is a case report of a 23 years old man who developed paracoccidioidomycosis meningitis achieved by fungus' presence in direct research and culture of cerebrospinal fluid. The meningeal form of paracoccidioidomycosis, its laboratorial and imaging diagnostic are discussed, and the importance of the routine investigation of the fungus is emphasized.

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Meningite paracoccidioidomicótica: relato de caso

Lorenzoni

Chang

Paniago

et al. 2002

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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Paracoccidioidomycosis Treatment

Shikanai-Yasuda

2015

Rev. Inst. Med. trop. S. Paulo

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SUMMARYConsidered to be an emerging endemic mycosis in Latin America, paracoccidioidomycosis is characterized by a chronic course and involvement of multiple organs in immunocompromised hosts. Infection sequelae are mainly related to pulmonary and adrenal insufficiency. The host-parasite interaction results in different expressions of the immune response depending on parasite pathogenicity, fungal load and genetic characteristics of the host. A few controlled and case series reports have shown that azoles and fast-acting sulfa derivatives are useful treatment alternatives in milder forms of the disease. For moderate/severe cases, more prolonged treatments or even parenteral routes are required especially when there is involvement of the digestive tract mucosa, resulting in poor drug absorption. Although comparative studies have reported that shorter treatment regimens with itraconazole are able to induce cure in chronically-infected patients, there are still treatment challenges such as the need for more controlled studies involving acute cases, the search for new drugs and combinations, and the search for compounds capable of modulating the immune response in severe cases as well as the paradoxical reactions.

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Neuroparacoccidioidomycosis: critical analysis of 33 cases

Cited by 2 publications

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Meningite paracoccidioidomicótica: relato de caso

Meningite paracoccidioidomicótica: relato de caso

Paracoccidioidomycosis Treatment

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