Brazilian studies on tropical spastic paraparesis: a meta-analysis

Costa, Carlos Maurício de Castro; Carton, Herwig; Goubau, Patrick; D'Almeida, José Artur Costa

doi:10.1590/s0004-282x1994000400023

Cited by 17 publications

(1 citation statement)

References 18 publications

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“…No Brasil, em 1989, Castro Costa e col. 3 descreveram pela primeira vez casos de paraparesia espástica tropical (PET); pouco tempo depois Martins Castro e col. 4 , descreveram os primeiros casos de PET com etiologia viral comprovada. Vários trabalhos têm sido publicados mostrando a presença do HTLV-I em quase todas as regiões do Brasil, relacionando-o com a etiologia da PET [5][6][7][8][9][10][11] ,que a partir de 1988 passou a ser denominada mielopatia associada ao HTLV-I / paraparesia espástica tropical (MAH/PET), designação adotada pela OMS para denominar esses quadros paraparéticos ou paraplégicos associados ao HTLV-I, tanto em zonas tropicais como temperadas.…”

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Mielopatia associada ao HTLV-I / paraparesia espástica tropical: relato dos primeiros casos em Sergipe

Oliveira

Melo²

1998

Arq. Neuro-Psiquiatr.

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Mielopatia associada ao HTLV-I / paraparesia espástica tropical (MAH/PET), tem sido descrita em quase todas as regiões do Brasil.Os autores apresentam oito casos clinicamente definidos como MAH/PET, os primeiros relatados no Estado de Sergipe .Todos foram positivos para HTLV-I, através do método ELISA, realizado duas vezes; em apenas dois casos foi possível a confirmação por Western Blot. De acordo com protocolo de investigação clínico-laboratorial, todos os pacientes apresentaram acometimento do tracto piramidal, com mínimo comprometimeto da sensibilidade e alterações esfincterianas. Os autores chamam a atenção para a endemicidade do HTLV-I no Estado, cuja prevalência entre doadores de sangue é significativa (0,43%).

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Mielopatia associada ao HTLV-I / paraparesia espástica tropical: relato dos primeiros casos em Sergipe

Oliveira

Melo²

1998

Arq. Neuro-Psiquiatr.

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Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil

Gomes

Melo

Proietti

et al. 1999

Journal of the Neurological Sciences

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HTLV-I infection represents a major health concern in endemic areas throughout the world, such as Salvador, the main city of Bahia State, with socio-demographic characteristics similar to sub-Saharan African cities, located in the Northeast of Brazil. In order to provide an estimate of the frequency distribution, and range of neurological manifestations potentially related to HTLV-I infection in this city, we conducted a cross-sectional clinical-epidemiological study to determine the prevalence of this infection in patients with neurological diseases. Patients exhibiting vascular diseases, tumoral diseases or trauma were excluded. Over a period of 16 months, we studied 322 consecutive patients with chronic neurological diseases, who attended the neurological clinics of two major hospitals in Salvador. Overall, the prevalence of HTLV-I infection among the patients was 20.9% (67/320). However, the prevalence among the 104 patients with chronic myelopathy was 50.0% (52/104). It was observed that the major prevalence of HTLV-I was between the ages of 40 and 60 years with a female predominance. Our data indicate that, in Salvador city, HTLV-I is associated with chronic myelopathies or myeloneuropathies, which seem to be the only neurological diseases associated with HTLV-I.

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Proposal for Diagnostic Criteria of Tropical Spastic Paraparesis/HTLV-I-Associated Myelopathy (TSP/HAM)

Castro-Costa

Araújo

Barreto

et al. 2006

AIDS Research and Human Retroviruses

232

182

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After the first description of TSP/HAM in 1985 and the elaboration of WHO's diagnostic criteria in 1988, the experience of the professionals in this field has increased so that a critical reappraisal of these diagnostic guidelines was considered timely. Brazilian neurologists and observers from other countries met recently to discuss and propose a modified model for diagnosing TSP/HAM with levels of ascertainment as definite, probable, and possible, according to myelopathic symptoms, serological findings, and/or detection of HTLV-I DNA and exclusion of other disorders.

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Brazilian studies on tropical spastic paraparesis: a meta-analysis

Abstract: SUMMARY -Tropical spastic paraparesis (TSP) is

Cited by 17 publications

References 18 publications

Mielopatia associada ao HTLV-I / paraparesia espástica tropical: relato dos primeiros casos em Sergipe

Mielopatia associada ao HTLV-I / paraparesia espástica tropical: relato dos primeiros casos em Sergipe

Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil

Proposal for Diagnostic Criteria of Tropical Spastic Paraparesis/HTLV-I-Associated Myelopathy (TSP/HAM)

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