Yawning

Alóe, Flávio

doi:10.1590/s0004-282x1994000200023

Cited by 12 publications

(3 citation statements)

References 17 publications

(12 reference statements)

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“…Yawning is one of the symptoms reported by individuals with migraine during the premonitory phase [39]. Several hypothalamic nuclei have been implicated in the mediation of yawning, including the dorsomedial nucleus, ventromedial nucleus, and anterior hypothalamus, but mainly the paraventricular nucleus (PVN) [40][41][42]. Yawning behavior in rodents can be elicited through a multitude of mechanisms but include especially dopaminergic agonists.…”

Section: Discussionmentioning

confidence: 99%

Exploring the neurobiology of the premonitory phase of migraine preclinically – a role for hypothalamic kappa opioid receptors?

et al. 2022

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Background The migraine premonitory phase is characterized in part by increased thirst, urination and yawning. Imaging studies show that the hypothalamus is activated in the premonitory phase. Stress is a well know migraine initiation factor which was demonstrated to engage dynorphin/kappa opioid receptors (KOR) signaling in several brain regions, including the hypothalamus. This study proposes the exploration of the possible link between hypothalamic KOR and migraine premonitory symptoms in rodent models. Methods Rats were treated systemically with the KOR agonist U-69,593 followed by yawning and urination monitoring. Apomorphine, a dopamine D1/2 agonist, was used as a positive control for yawning behaviors. Urination and water consumption following systemic administration of U-69,593 was also assessed. To examine if KOR activation specifically in the hypothalamus can promote premonitory symptoms, AAV8-hSyn-DIO-hM4Di (Gi-DREADD)-mCherry viral vector was microinjected into the right arcuate nucleus (ARC) of female and male KORCRE or KORWT mice. Four weeks after the injection, clozapine N-oxide (CNO) was administered systemically followed by the assessment of urination, water consumption and tactile sensory response. Results Systemic administration of U-69,593 increased urination but did not produce yawning in rats. Systemic KOR agonist also increased urination in mice as well as water consumption. Cell specific Gi-DREADD activation (i.e., inhibition through Gi-coupled signaling) of KORCRE neurons in the ARC also increased water consumption and the total volume of urine in mice but did not affect tactile sensory responses. Conclusion Our studies in rodents identified the KOR in a hypothalamic region as a mechanism that promotes behaviors consistent with clinically-observed premonitory symptoms of migraine, including increased thirst and urination but not yawning. Importantly, these behaviors occurred in the absence of pain responses, consistent with the emergence of the premonitory phase before the headache phase. Early intervention for preventive treatment even before the headache phase may be achievable by targeting the hypothalamic KOR.

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Section: Discussionmentioning

confidence: 99%

Exploring the neurobiology of the premonitory phase of migraine preclinically – a role for hypothalamic kappa opioid receptors?

et al. 2022

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“…Yawning, frequent in daily life, is accepted as a complex arousal reflex located in the reticular brainstem with both peripheral and central arches. Although its mechanisms and functional role are still quite a mystery to science, animal experiments have shown the involvement of several neurotransmitters (dopamine, acetylcholine, adrenocorticotropic hormone, oxytocine, serotonin, neuropeptides, hypocretin and sexual hormones) in its generation and modulation (Alóe, 1994;Daquin, et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Pathological yawning in a patient with anxiety and chronic disease anaemia

et al. 2008

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Yawning, frequent in daily life, is accepted as a complex arousal reflex. Excessive yawning may be due to neurological, psychiatric, infectious, gastrointestinal or metabolic diseases. This reflex has also been associated with different selective serotonin reuptake inhibitors. We report a female patient, with excessive yawning, who was on selective serotonin reuptake inhibitor treatment with the diagnosis of generalised anxiety disorder. She was then found to have endometrial carcinoma. Her complaints of palpitation, shortness of breath and loss of energy might be explained by a psychiatric disease and/or anaemia. Previous anaemic periods and partial response of her psychiatric symptoms during last 3 years alerted us to think about an organic cause. Investigations for chronic disease anaemia resulted in diagnosis of endometrial carcinoma. This case is a good example showing misdiagnosis caused by medical stigmatisation.

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“…Valproate overdose, dopamine agonists, imipramine, withdrawal from morphine, and estrogen substitution may also induce pathological yawning [6,12,14,15]. Neuropharmacological experimental studies show that dopaminergic, cholinergic, ACTHergic, and oxytocinergic systems are part of the complex behavioral response of yawning [1]. Studies in man have stressed the importance of the dopaminergic system in the generation of yawning.…”

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confidence: 99%