Cognitive impairment in human chronic Chagas' disease

Mangone, Carlos A.; Sica, R. E. P.; Pereyra, Silvia; Genovese, Osvaldo; Segura, Elsa L.; Riarte, Adelina; Sanz, Olga; Segura, Marcela

doi:10.1590/s0004-282x1994000200008

Cited by 32 publications

(33 citation statements)

References 7 publications

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“…Therefore, chagasic subjects may also be susceptible to psycho-functional derangements attendant on functional demands for higher cerebral processes in association with their autonomic cardiovascular adaptive disability, as suggested by some evidences 91,92 . In fact, at least in other clinical conditions as the Alzheimer's disease, cognitive status and cardiac autonomic modulation evaluated by heart rate variability appear to be correlated in the sense that people with lower cardiac parasympathetic modulation and tendency for higher sympathetic modulation show more severe cognitive deficiencies 93 .…”

Section: Other Possible Effects Of Autonomic Dysfunctionmentioning

confidence: 99%

Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease

Junqueira Junior

2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Exclusive or associated lesions in various structures of the autonomic nervous system occur in the chronic forms of Chagas disease. In the indeterminate form, the lesions are absent or mild, whereas in the exclusive or combined heart and digestive disease forms, they are often more pronounced. Depending on their severity these lesions can result mainly in cardiac parasympathetic dysfunction but also in sympathetic dysfunction of variable degrees. Despite the key autonomic effect on cardiovascular functioning, the pathophysiological and clinical significance of the cardiac autonomic dysfunction in Chagas disease remains unknown. METHODS: Review of data on the cardiac autonomic dysfunction in Chagas disease and their potential consequences, and considerations supporting the possible relationship between this disturbance and general or cardiovascular clinical and functional adverse outcomes. RESULTS: We hypothesise that possible consequences that cardiac dysautonomia might variably occasion or predispose in Chagas disease include: transient or sustained arrhythmias, sudden cardiac death, adverse overall and cardiovascular prognosis with enhanced morbidity and mortality, an inability of the cardiovascular system to adjust to functional demands and/or respond to internal or external stimuli by adjusting heart rate and other hemodynamic variables, and immunomodulatory and cognitive disturbances. CONCLUSIONS: Impaired cardiac autonomic modulation in Chagas disease might not be a mere epiphenomenon without significance. Indirect evidences point for a likely important role of this alteration as a primary predisposing or triggering cause or mediator favouring the development of subtle or evident secondary cardiovascular functional disturbances and clinical consequences, and influencing adverse outcomes.

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Section: Other Possible Effects Of Autonomic Dysfunctionmentioning

confidence: 99%

Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease

Junqueira Junior

2012

Rev. Soc. Bras. Med. Trop.

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“…Com base na referida revisão sistemática, Hueb e Loureiro (2005) identificaram cinco estudos que abordaram os aspectos cognitivos (JORG et al, 1972;MANGONE et al, 1994aMANGONE et al, , 1994bMONCADA et al, 1987;PEREYRA et al, 1992). Tais estudos trataram da inteligência em seus aspectos gerais e específicos, trabalhando com a hipótese de que a doença de Chagas afeta o funcionamento cognitivo dos portadores.…”

Section: Aspectos Cognitivos E Doença De Chagasunclassified

Doença de Chagas: indicadores cognitivos, de transtorno orgânico cerebral, de uso de álcool e qualidade de vida

Hueb¹

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“…Additionally, the various stages of this disease -acute, indeterminate and chronic -make it ideal for studying its covariance with neurocognitive and depressive symptoms. A search through previous literature yielded only one related study: Mangone et al in 1994 suggested that Chagas patients may be impaired in their orientation, attention, nonverbal reasoning, information processing, learning and sequencing 22 . Additionally, according to Oliveira Jr…”

Section: Implications and Conclusionmentioning

confidence: 99%

Chagas disease as a mechanistic model for testing a novel hypothesis

Mosovich

Mady

Lopes

et al. 2008

Rev. Soc. Bras. Med. Trop.

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The association between depression and cardiovascular disease is well documented. Nevertheless, the process through which they are linked remains unknown, as does the direction of this relationship. Studies have suggested both that depression is a risk factor for heart disease and that heart disease is a risk factor for depression. A number of studies have established that a relationship exists between depression and inflammation, with alterations in the levels of inflammatory markers (IL-1, IL-6, TNF-alpha and others). Depressive symptoms have also been identified in many diseases characterized by inflammatory processes e.g. rheumatoid arthritis, bronchial asthma, diabetes, tuberculosis and cardiovascular diseases. In this brief viewpoint, we explain and propose how to use Chagas disease, a disorder characterized by inflammatory processes and leading to cardiovascular and autonomic problems, as a model for studying the directionality of the relationship between heart disease and depression. Key-words: Chagas disease. Depression. RESUMOA associação entre depressão e doença cardiovascular está bem documentada. Não obstante, o processo pelo qual está associada permanece desconhecido, assim como o sentido desta associação. Estudos têm sugerido que tanto a depressão é um fator de risco para a doença cardiovascular quanto esta o é para a depressão. Uma série de trabalhos tem estabelecido que uma relação existe entre depressão e inflamação, com alterações evidenciadas por marcadores de inflamação (IL-1, IL-6, TNF alfa e outros). Sintomas de depressão também têm sido identificados em diversas doenças caracterizadas por processos inflamatórios, tais como artrite reumatoide, asma brônquica, diabete, tuberculose e doenças cardiovasculares. Nesta breve opinião é explicitado e proposto como empregar a doença de Chagas, um agravo caracterizado por processos inflamatórios e indutor de problemas cardiovasculares e autonômicos, como um modelo de estudo da direcionalidade da relação entre doença cardíaca e depressão.Palavras-chaves: Doença de Chagas. Depressão.Depressão.

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Cognitive impairment in human chronic Chagas' disease

Cited by 32 publications

References 7 publications

Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease

Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease

Doença de Chagas: indicadores cognitivos, de transtorno orgânico cerebral, de uso de álcool e qualidade de vida

Chagas disease as a mechanistic model for testing a novel hypothesis

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