Meduloblastoma desmoplásico: fatores histológicos de prognóstico

Abstract

The histological features of eight cases of desmoplastic medulloblastoma were investigated and compared to classic medulloblastoma. The most benign histologic neoplasms belong to the group of desmoplastic medulloblastoma, characterized by low necrosis, low mitosis and light nuclear pleomorphism.

Meduloblastoma: correlação entre ressonância magnética convencional, difusão e espectroscopia de prótons

“…Such finding may be associated with limitations of the relatively small sample. Differently from the literature (10,11) , 75% of the cases with desmoplastic variant in the presence of tumor cysts/necrosis was observed in 100% of cases. Several authors have found the presence of cysts/necrosis in medulloblastomas, with prevalence ranging from 47% to 82% of cases (4,6,13,18) .…”

“…This difference in localization seems to be associated with the migration of undifferentiated cells of the posterior medullary velum into upper and lateral directions (8,(12)(13)(14) . The desmoplastic variant is preferentially localized in the cerebellar hemisphere (10,11) , however, in the present small series, despite the predominance of the desmoplastic variant, the preferential site of medulloblastoma was the cerebellar vermis. The tumor was found centered in the cerebellar hemisphere in only one case (11.1%), a four-year-old child.…”

“…The incidence is higher in male individuals, with a male/female ratio = 1.5-2:1 (8) . The desmoplastic variant occurs typically in adolescents or young adults (10,11) . In the present study, a female predominance was observed (female/male, 2:1).…”

Metachronic Breast and Cerebellar Neoplasm in a Young Patient

“…11,12 The nodular/desmoplastic medulloblastoma has characteristics that distinguish it from typical tumors, since it is usually well circumscribed, contains a large amount of reticulin fibers and, when completely removed, has a better prognosis. 13 It is mainly located in the cerebellar hemisphere but may also be located in the cerebellar vertebra. 14 Some authors consider less aggressive histological alterations due to the lower occurrence of necrosis, lower mitotic index, and nuclear alterations are classified as mild when compared with the group of classical medulloblastomas.…”

“…14 Some authors consider less aggressive histological alterations due to the lower occurrence of necrosis, lower mitotic index, and nuclear alterations are classified as mild when compared with the group of classical medulloblastomas. 13 The clinical picture is insidious and progressive, making the patient complain of lumbar or radicular pain, seizures, cranial hypertension, and focal medullary or encephalic symptoms due to neoplastic implants. Headache appears as a predominant symptom in adults with this type of tumor.…”