An evoked potential mapping of transcallosal projections in the cat

Cukiert, Arthur; Timo-Iaria, C.

doi:10.1590/s0004-282x1989000100001

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Extensive human clinical data emphasized the role of the corpus callosum on secondary bilateral synchrony genesis and strongly suggest that complete callosal section would be the best option to disrupt completely the secondary bilateral synchrony in patients with secondarily generalized epilepsy (14). We believe that complete callosal section is the best treatment option for these patients.…”

Section: Discussionmentioning

confidence: 99%

Extended, One‐stage Callosal Section for Treatment of Refractory Secondarily Generalized Epilepsy in Patients with Lennox–Gastaut and Lennox‐like Syndromes

et al. 2006

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Summary: Purpose:We report on the efficacy and safety of extended one-stage callosal section performed in a large and homogeneous series of patients.Methods: Seventy-six patients with Lennox-Gastaut (n = 28) and Lennox-like (n = 48) syndrome were studied (42 male patients; mean age, 11.2 years). All patients had multiple seizure types per day, including atonic, tonic-clonic, atypical absence, myoclonic, and tonic seizures. All of them were developmentally impaired. The EEG showed intense secondary bilateral synchrony in all of them. All patients were submitted to an extended, one-stage, callosal section, leaving only the splenium intact. Mean follow-up time was 4.7 years.Results: Worthwhile improvement (>50%) was noted in 69 of 76 patients; 52 patients had a ≥90% reduction in seizure frequency. Seven patients were seizure free after surgery. The seizure patterns most responsive to surgery were atonic (92%), atypical absence (82%), and tonic-clonic (57%) seizures. All patients had some degree of a transient acute postoperative disconnection syndrome. A consistent increase in attention level was observed postoperatively.Conclusions: We report one of the larger homogeneous series of patients submitted to callosotomy and are the first to report on the effectiveness and safety of performing extended callosal section in a single stage in this patient group. Extended callosal section should be considered a good palliative surgical option for suitable candidates. The increase in attention level was as useful as seizure control in improving quality of life of these patients.

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Section: Discussionmentioning

confidence: 99%

Extended, One‐stage Callosal Section for Treatment of Refractory Secondarily Generalized Epilepsy in Patients with Lennox–Gastaut and Lennox‐like Syndromes

et al. 2006

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“…Cukiert and Timo-Iaria [1989] reported that the initial response started at 2-10 ms and the second peak at 10-25 ms. Single neuron recording in animals demonstrated that the initial unit arrived at 6-8 ms by stimulating the opposite pyramidal tract in cat [Asanuma and Okuda, 1962].…”

Section: Latenciesmentioning

confidence: 99%

Uneven interhemispheric connections between left and right primary sensori‐motor areas

Terada¹,

Umeoka²,

Usui³

et al. 2011

Human Brain Mapping

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To clarify the characteristics of interhemispheric connections, we investigated cortico-cortical evoked potentials (CCEP) in human. Fourteen patients with temporal lobe epilepsy who underwent invasive EEG monitoring with bilaterally implanted subdural electrodes were studied. Electric pulse stimuli were given in a bipolar fashion at two adjacent electrodes on and around the motor area (MA) or sensory area (SA), and CCEP responses were recorded by averaging electrocorticograms from the contralateral hemisphere. Seventy-two pairs of electrodes were stimulated, and 468 recordings were analyzed. Fifty-one of 468 recordings demonstrated CCEP responses. Of 51 responses, 16 consisted of an initial positive triphasic wave (Type 1), 27 had an initial negative biphasic wave (Type 2), and 8 showed an initial positive biphasic wave (type 3). The mean latencies of the earliest peaks were 13.1, 28.9, and 29.4 ms in Types 1, 2, and 3 responses, respectively. The responses were more frequently evoked by stimulating facial MA (f-MA) and nonfacial MA (nf-MA) than by stimulating SA or noneloquent area. In both f-MA and nf-MA stimulation, the responses were more frequently recorded at the contralateral f-MA than at the contralateral nf-MA or other areas. SA stimulation never evoked CCEP responses at the contralateral MA or SA. The amplitudes were maximal when f-MA was stimulated and responses recorded at the contralateral f-MA. These findings suggest that the interhemispheric connections are uneven. Both f-MA and nf-MA send dense interhemispheric connections to the contralateral f-MA. SA may have no or only rare direct connection with the contralateral MA or SA.

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“…In animal studies, evoked potential was employed even in historic studies (Chang, 1953;Cukiert and Timo-Iaria, 1989;Curtis 1940a, b). Subsequently, similar methods were applied to the human brain by stimulating mesial temporal structures (Rutecki et al, 1989;Wilson et al, 1990Wilson et al, , 1991, corpus callosum (Ono et al, 2002), Heschl's gyrus (Brugge et al, 2003), inferior frontal gyrus (Greenlee et al, 2004), MC (Greenlee et al, 2004), and primary sensory area (Matsumoto et al, 2005).…”

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confidence: 99%

Interhemispheric Connection of Motor Areas in Humans

Terada

Usui

Umeoka

et al. 2008

Journal of Clinical Neurophysiology

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We attempted to clarify functional interhemispheric connections of motor cortex (MC) by investigating cortico-cortical evoked potentials from human brains in vivo. Three patients with intractable epilepsy who underwent invasive EEG monitoring with subdural electrodes as presurgical evaluation were studied. Electric pulse stimuli were delivered in a bipolar fashion to two adjacent electrodes on and around MC. Cortico-cortical evoked potentials were recorded by averaging electrocorticograms from the contralateral hemisphere. An initial positive triphasic or an initial negative biphasic wave was recorded when the contralateral MCs were stimulated. When the non-MC electrodes were stimulated, no response was recorded. The latencies ranged from 9.2 to 23.8 ms for the initial positive peak, and 25.4 to 39.4 ms for the initial or the second negative peak. The cortico-cortical evoked potentials responses were maximal around the homonymous electrodes with the stimulated electrodes. Our results directly demonstrate the presence of the functional interhemispheric connections originating in MC. The interhemispheric transit time is indicated. The homotopic distribution of the responses indicates that motor coordination of the bilateral bodies is, at least partially, controlled within MC.

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An evoked potential mapping of transcallosal projections in the cat

Cited by 8 publications

References 25 publications

Extended, One‐stage Callosal Section for Treatment of Refractory Secondarily Generalized Epilepsy in Patients with Lennox–Gastaut and Lennox‐like Syndromes

Extended, One‐stage Callosal Section for Treatment of Refractory Secondarily Generalized Epilepsy in Patients with Lennox–Gastaut and Lennox‐like Syndromes

Uneven interhemispheric connections between left and right primary sensori‐motor areas

Interhemispheric Connection of Motor Areas in Humans

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