Cordotomia percutânea com radiofrequência: resultados em 62 casos operados

Guelmann, Joel M.

doi:10.1590/s0004-282x1980000300001

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Canine WES and WGS data were downloaded from the Sequence Read Archive (SRA) database, including PRJNA489159 (mammary tumor), PRJEB12081 (oral melanoma), PRJNA579792 (glioma), PRJNA552034 (hemangiosarcoma), PRJNA247493 (osteosarcoma, lymphoma, and unclassified) and others listed in Supplementary Data 1 . We also obtained other information from relevant publications 11 – 20 , 24 , 41 , 42 .…”

Section: Methodsmentioning

confidence: 99%

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

Alsaihati

Watson

et al. 2021

Nat Commun

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Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our results indicate that canine tumor alteration landscape is tumor type-dependent, but likely breed-independent. Each tumor type harbors major pathway alterations also found in its human counterpart (e.g., PI3K in mammary tumor and p53 in osteosarcoma). Mammary tumor and glioma have lower tumor mutational burden (TMB) (median < 0.5 mutations per Mb), whereas oral melanoma, osteosarcoma and hemangiosarcoma have higher TMB (median ≥ 1 mutations per Mb). Across tumor types and breeds, TMB is associated with mutation of TP53 but not PIK3CA, the most mutated genes. Golden Retrievers harbor a TMB-associated and osteosarcoma-enriched mutation signature. Here, we provide a snapshot of canine mutations across major tumor types and breeds.

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