Tuberculose meningo-encefalica na infância: estudo anatomo-patologico de 10 casos

Coutinho, Lígia Maria Barbosa; Tarrago, Ricardo

doi:10.1590/s0004-282x1976000200003

Cited by 2 publications

(5 citation statements)

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“…The severe histologic lesions in the tunica intima of the meningeal vessels, described before in human encephalic tuberculosis cases (Coutinho & Tarragô 1976), suggest the invasion of the agent in the CNS through the hematogenous way. In humans, through angiographies, it is possible to identify tortuosity and aneurisms provoked by vascular compression, vasculitis and/or proliferation of the tunica intima of the blood vessels (Coutinho & Tarragô 1976). The meningeal vessels are, therefore, the first affected by the inflammation, and the proliferation of the tunica intima may provoke complete occlusion of the vascular lumen, causing encephalic infarcts (Oruç 2005, Zachary 2013).…”

Section: Discussionmentioning

confidence: 67%

“…The divergency in nervous clinical signs among the cases occurred possibly because of the different lesion intensity in the neuropil and its location (Coutinho & Tarragô 1976, Oruç 2005, Riet-Correa et al 2002, Del Fava et al 2010, Konradt et al 2016, The chronicity may have influenced in the degree of the CNS lesion (Rock et al 2008), since Bovines 1, 3 and 6 that presented granulomatous meningitis and compressive lesions, without significant alterations of the adjacent nervous tissue, did not show neurological clinical disturbances; while the bovines with diffuse and accentuated lesions in the meninges and brain tissues (Bovines 2, 4 and 5) presented nervous signs.…”

Section: Discussionmentioning

confidence: 99%

“…After invading the organism, Mycobacterium spp. infects macrophages that will circulate in the blood flow and reach several organs, as liver, lymph nodes, kidneys, spleen, uterus, mammary gland, eye and the CNS (Coutinho & Tarragô 1976, Oruç 2005, Del Fava et al 2010, Domingo et al 2014, Tizard 2014. In the CNS the agent is also capable to infect microglia cells (Rock et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms determining the location of tuberculosis lesions in the different regions of the CNS are not known, however, three well-defined forms of presentation in humans are known: meningeal thickening, miliary distribution, and unique tuberculous formation (Coutinho & Tarragô 1976). Among the tuberculosis lesions observed in this report, the meningeal thickening was the most frequent, seen in five of the six cases studied in this study.…”

Section: Discussionmentioning

confidence: 99%

“…In the only case that the liquor was examined, lymphocytosis was confirmed, suggesting that the routine use of this technique, associated to the Ziehl-Neelsen stain, or to the isolation or molecular identification of the agent, may help in the diagnosis of the nervous form of tuberculosis. Humans with encephalic tuberculosis may present high lymphocyte cellular population in the liquor cytology; however, in the cases in which the infection is in the initial phase, neutrophils in greater quantity may be visualized (Coutinho & Tarragô 1976, Rock et al 2008. Besides the evaluation of the inflammatory cells present in the liquor, the Ziehl-Neelsen technique can be performed to observe the agent in the cerebrospinal fluid, though the absence of bacillus does not imply in the exclusion of the disease (Wilkins et al 1986).…”

Section: Discussionmentioning

confidence: 99%

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Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

et al. 2018

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This paper describes six cases of tuberculosis in the central nervous system (CNS) of cattle in the state of Paraíba in northeastern Brazil. We reviewed the autopsy reports of 851 bovine necropsies performed from 2003 to 2016. Seventy-three (8.6%) cattle were diagnosed with tuberculosis and six showed lesions in the CNS. Three cases affected cattle up to two-year-old and other three affected adults. Three cattle presented exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical signs. At necropsy, five cattle had thickening of the leptomeninges of the cerebellum, pons, obex, spinal cord and cortex, mainly, in the region near the brain basilar Willis´ circle. Another animal, presented a single focal lesion in the cerebellum. Microscopically we observed moderate to severe granulomatous meningitis and encephalitis. Five cattle presented lesions in the lungs and mediastinal lymph nodes and three of them had disseminated lesions in other organs. In all cattle acid-fast bacilli were observed in the lesions and marked positive for immunohistochemistry with polyclonal antibody anti-Mycobacterium tuberculosis. It is concluded that bovine tuberculosis of central nervous system occurs sporadically in Paraíba, in cattle of different ages, most of them with disseminate lesions in other organs. The location of the lesions suggests that the agent invaded the brain by hematogenous route through the circle of Willis.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

et al. 2018

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Tuberculose em necropsias realizadas no Serviço de Anatomia Patológica da Faculdade de Medicina de Botucatu

Joaquim¹,

Carandina²,

Defaveri³

2006

J. Bras. Patol. Med. Lab.

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unitermos key words resumo Entre 6.316 necropsias realizadas, no período de 1969 a 2000, no Departamento de Patologia da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (FMB/UNESP), foram encontradas 240 necropsias com diagnóstico de tuberculose, sendo 117 registradas como doença principal (grupo tuberculose/doença principal) e 123, como doença associada (grupo tuberculose/doença associada). No grupo tuberculose/doença principal, 100% apresentavam tuberculose ativa, com 80 ocorrências em homens e 37 em mulheres e média de idade de 47,7 anos. Caquexia (37,2%) e cor pulmonale (23,7%) foram as co-morbidades mais prevalentes nesse grupo. Os pulmões estavam comprometidos em 95,7% dos casos, seguido pelos linfonodos (38,9%) e pleuras (27,1%). Os padrões morfológicos das lesões pulmonares foram: 1. miliar, 58,4%; 2. cavernas, 56,6%; 3. fibrose, 41,5%; 4. bronquiectasias, 26,5%; 5. enfisema, 19,4%; e 6. cistos, 1,7%. Cavernas foram observadas em diferentes áreas, com discreto predomínio no pulmão direito, sendo a localização apical preferencial (100%) e quase sempre bilaterais (94%). Lesões miliares, bronquiectasias e fibrose estavam distribuídas, de forma difusa e aleatória, nos pulmões. No grupo tuberculose/doença associada também houve predomínio de homens (70,8%). Nesses casos, a AIDS e o alcoolismo crônico foram as doenças principais mais freqüentes, representando 22% e 16,3%, respectivamente. Os pulmões estavam acometidos em 85,2% dessas necropsias (100% nos casos de AIDS), seguidos pelos linfonodos (31,9%) e baço (28,6%). Nossos dados corroboram a importância da necropsia no estudo e no conhecimento da tuberculose, fornecendo subsídios para uma melhor abordagem clínica e epidemiológica dessa doença em nossa região. Tuberculose NecropsiasPatologia Epidemiologia abstract Among 6,316 necropsies performed in the period 1969-2000 at the Department of Pathology of Botucatu Medical School UNESP, 240 were of tuberculosis. Among them, 117 were registered as the principal disease (tuberculosis/principal disease group) and 123, as associated to another disease (tuberculosis/associated disease group). In the tuberculosis-principal disease group, 100% had active tuberculosis, 80 patients were male and 37 were female, with mean age of 47.7 years. Cachexia (37.2%) and cor pulmonale (23.7%) were the most prevalent comorbities in this group. The lungs were affected in 95.7% of the cases, followed by lymph nodes (38.9%) and pleura (27.1%). The morphology and frequency of pulmonary lesions were: 1. miliar: 58. 4%; 2. caverns, 56.6%; 3. fibrosis, 41.5%; 4. bronchiectasias, 26.5%; 5. emphysema, 19.4% and 6. cysts, 1.7%. Caverns were observed in different areas of both lungs, with discreet predominance in the right lung, were located mainly in the apices (100%), and the great majority (94%) was bilateral. The others lesions were distributed randomly in both lungs. In the tuberculosis/associated disease group, 70.8% was male, and the two most frequent principal diseases were AIDS (22.1%) and alcoholism (16.3%). Als...

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Tuberculose meningo-encefalica na infância: estudo anatomo-patologico de 10 casos

Cited by 2 publications

References 13 publications

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

Tuberculose em necropsias realizadas no Serviço de Anatomia Patológica da Faculdade de Medicina de Botucatu

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