Síndrome de Melkersson-Rosenthal: relato de 4 casos e revisão da literatura

Lemmi, Octavio; Souza-Lima, José Edmilson de; Medeiros, Milton; Pimentel, Pedro Camilo de A.

doi:10.1590/s0004-282x1973000100005

Cited by 1 publication

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“…Melkersson-Rosenthal syndrome (MRS) is a rare granulomatous neuro-mucocutaneous condition [ 1 ] characterized by the triad facial paralysis, ipsilateral facial edema, and fissured tongue. In 1928, Melkersson described the paralysis and facial edema, and 3 years later, Rosenthal observed that those symptoms were presented in outbreaks, and were frequently associated with fissured tongue [ 2 ]. Nevertheless, it was only in 1949 when the term ‘Melkersson-Rosenthal syndrome’ was used for the first time, by Luscher [ 3 ], [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Melkersson-Rosenthal syndrome: a rare variant of the monosymptomatic form

Estacia

Filho

Silveira

et al. 2022

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Melkersson-Rosenthal syndrome (MRS) is a rare condition without any known etiology. It is characterized by the triad facial paralysis, facial swelling, and the development of folds and furrows at the tongue (fissured tongue). This study aims to report a case of a 59-year-old patient complaining about asymmetric eyelid swelling that had started two years before, associated with pain and redness on her right eye, without repercussions on her visual acuity. The patient underwent a skin biopsy of the right eye’s lower eyelid, which was compatible with the monosymptomatic form of MRS. Consequently, five injections of triamcinolone were performed for the period of one year, with gradual and satisfactory improvement. One year after the end of the treatment, the patient returned with recurrence of the swelling, and therapy with triamcinolone associated with oral steroids was started. However, due to the lack of improvement, Tacrolimus ointment 0.03% was initiated. The patient evolved with an important and significant reduction of the eyelid edema, still being followed at the Hospital Federal dos Servidores do Estado do Rio de Janeiro.

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Section: Discussionmentioning

confidence: 99%