Amiloidose primária com comprometimento meningo-radículo-neurítico

Juliäo, O. Freitas; Mignone, Constantino

doi:10.1590/s0004-282x1955000100001

Cited by 8 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first cases of FAP in Brazil were formally reported in the 1950s [3,4] and since then only a few papers were published on this subject. According to these reports [5–7], Brazilian patients present a very similar phenotype to the one described in Portuguese patients, with an early age of onset, high penetrance and significant involvement of small fibers and the autonomic nervous system.…”

Section: Introductionmentioning

confidence: 99%

Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families

Saporta

Zaros

Cruz

et al. 2009

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families

Saporta

Zaros

Cruz

et al. 2009

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Systemic amyloidoses constitute a large group of diseases, in which the main characteristic is the formation of amyloid protein deposits in the extracellular environment 12 , causing dysfunction of several organs, such as the heart, kidney, liver, gastrointestinal tract, and nerves 10,12,13 . Systemic amyloidoses can be primary, secondary to inflammatory and autoimmune diseases, or hereditary; they are classified according to the deposited amyloid protein 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report

Santos

Fernandes

Barbosa

et al. 2021

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

OBJECTIVE:To review the literature and to report a clinical case with initial suspicion of pure neural leprosy and final diagnosis of amyloid neuropathy. METHODS:The study was conducted in two stages. In stage one, a systematic literature review was carried out, with searches performed in the PubMed, Medline, and Lilacs databases, as well as in the leprosy sectoral library of the Virtual Health Library, using the following descriptors: neuritic leprosy, pure neural leprosy, primary neural leprosy, pure neuritic leprosy, amyloid polyneuropathy, amyloid neuropathies, and amyloid polyneuropathy. The search was carried out on May 28, 2020. Clinical trials, cohort studies, crosssectional studies, clinical cases, and case studies published in Portuguese, English or Spanish between 2010 and 2020 were included.Stage two reports a case with initial suspicion of pure neural leprosy. Laboratory tests, electroneuromyography, ultrasound, and biopsy of the sural nerve were requested.RESULTS: Twenty-three scientific texts were included. No publications were found that contained both topics together. The challenging diagnosis of pure neural leprosy and the possibility of using auxiliary resources in diagnosis were the most emphasized themes in the studies. In the clinical case, the patient's electroneuromyography showed sensitive and motor polyneuropathy of the lower limbs, which was predominantly sensory and axonal, symmetrical, of moderate intensity, and the mixed type (axonal-demyelinating). Ultrasonography of the sural nerve revealed changes in the contour of the deep fibular nerves; biopsy of the sural nerve showed an accumulation of amorphous eosinophilic material in the nerve path, and Congo red stain showed apple-green birefringence of the deposit under polarized light. The final diagnosis was amyloid neuropathy. CONCLUSIONS:The final clinical diagnosis was amyloid neuropathy. The diagnosis of pure neural leprosy in endemic areas in Brasil is still a challenge for the health system.

show abstract

“…Although not restricted to the Oporto district, it is most common in that part of Portugal; 173 families are known to be affected (Andrade, 1970). Cases of Portuguese origin have been reported from Brazil (Juliao and Mignone, 1955; Mello, 1959;Juliao et al, 1974), Germany (Erbsloh, 1961), and the United States (Munsat and Poussaint, 1962).…”

mentioning

confidence: 99%

Genetic factors in amyloidosis.

Thomas¹

1975

Journal of Medical Genetics

View full text Add to dashboard Cite

Amiloidose primária com comprometimento meningo-radículo-neurítico

Cited by 8 publications

References 3 publications

Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families

Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families

Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report

Genetic factors in amyloidosis.

Contact Info

Product

Resources

About