Hiv and Hepatitis C Virus Coinfection. Who Is This Patient Today?

Antonello, Vicente Sperb; Antonello, Ivan Carlos Ferreira; Zaltron, Rosana Ferrazza; Tovo, Cristiane Valle

doi:10.1590/s0004-28032016000300011

Cited by 2 publications

(2 citation statements)

References 31 publications

(40 reference statements)

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“…The improvement in the immunity and, consequently, the survival of these patients led to a decrease in diseases related to the human immunodeficiency syndrome (which would invariably lead to death within only a few months). This has led to an increase in the incidence of diseases not directly related to HIV, especially neoplasms and liver disease[ 24 , 34 , 35 , 38 , 42 , 43 , 48 , 49 ]. In this scenario, HBV, HCV and alcohol abuse - factors often related to HIV infection - deserve attention[ 9 , 49 - 51 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study

Marcon

Tovo

Kliemann

et al. 2018

WJG

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AIMTo assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV).METHODSA retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records review.RESULTSOf 804 patients were included (399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger (36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected (P < 0.001). HCC was diagnosed in 36 patients (10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years (95%CI: 0.12-0.46 vs 0.47-1.05) (long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC.CONCLUSIONIn this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence.

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Section: Discussionmentioning

confidence: 99%

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study

Marcon

Tovo

Kliemann

et al. 2018

WJG

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“…Распространенность вирусного гепатита С в мире неодинакова. Анализ выявляемости маркеров вируса гепатита С (ВГС) среди ВИЧ-позитивных граждан Латинской Америки показал, что ее уровень варьирует в зависимости от регионаот 6,5% в Аргентине среди коммерческих сексработников до 11,8% в Бразилии среди ВИЧ-позитивных лиц, стоящих на диспансерном учете [1][2][3].…”

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Molecular-Genetic Peculiarities of Hepatitis С Virus in Patients With Hiv-Infection Residing in the Russian Far East

Базыкина

Туркутюков

Троценко

et al. 2020

VIČ-infekc. immunosupr.

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The Aim: to evaluate abundance and molecular-genetic characteristics of hepatitis С virus (HCV) among HIV-positive patients residing in the constituent entities of the Far Eastern Federal district.Materials and methods. Detection of HCV serological markers (HCVsum) was performed via enzyme-linked immunosorbent assay among HIV-positive individuals (n=350) and apparently healthy people (ﬁrst control group; n=368). In order to conduct comparative evaluation of age-sex composition and HBV-infection markers abundance a second control group of patients with diagnosis of chronic viral hepatitis (n=88) was selected. RNA-positive samples were subjected to molecular-genetic analysis: NS5B HCV genome part (241 bp and 350 bp) was examined. Results and discussion. The odds ratio of being infected with HCV was over 47 times higher in HIV-population in comparison to apparently health people. HIV-HCV positive patient occurred to be younger rather than patient with diagnosis of chronic viral hepatitis C. It was revealed that in the HIV-HCV co-infected group male patients were prevalent compared to controls. The most prevalent HCV subgenotype was 3a. High prevalence of 3a HCV subgenotype among HIV-infected individuals was probably related to high abundance of intravenous drug use in the studied group. Analysis of the phylogenetic tree showed considerable clusterization of isolated part of gene sequences. This fact can be due to plural infection sources that presumably have no epidemiological connection.

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Hiv and Hepatitis C Virus Coinfection. Who Is This Patient Today?

Abstract: - Clinicians should recognize that coinfected and monoinfected individuals are different groups regarding the traditional and HIV-related risk factors and should be managed and screened individually in order to prevent cardiovascular and renal complications.

Cited by 2 publications

References 31 publications

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study

Molecular-Genetic Peculiarities of Hepatitis С Virus in Patients With Hiv-Infection Residing in the Russian Far East

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