H. PYLORI INFECTION, ENDOSCOPIC, HISTOLOGICAL ASPECTS AND CELL PROLIFERATION IN THE GASTRIC MUCOSA OF PATIENTS SUBMITTED TO ROUX-EN-Y GASTRIC BYPASS WITH CONTENTION RING: a cross sectional endoscopic and immunohistochemical study

Nogueira, Thiago de Bortoli; Neto, Ricardo Artigiani; Filho, Benedito Herani; Waisberg, Jaques

doi:10.1590/s0004-28032016000100011

Cited by 3 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast with other reports, we have found no association between EBV status and patients’ age[ 8 , 26 ]. Regarding the tumour location, our study revealed a higher predominance of EBVaGC in upper third and middle of stomach and considering that H. pylori preferentially colonises the antral region, these results suggest a possible antagonism of EBV and H. pylori in gastric mucosa[ 27 - 29 ]. In fact, Minoura-Etoh et al[ 30 ] described in an in vitro study that reactive products from H. pylori seem to induce EBV reactivation from latently in infected gastric epithelial cells, which would avoid EBV transformation of gastric cells in the same areas of H. pylori colonization.…”

Section: Discussionmentioning

confidence: 87%

Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in Portugal

Ribeiro

Oliveira

Malta

et al. 2017

WJG

View full text Add to dashboard Cite

AIMTo determine the prevalence of Epstein-Barr virus (EBV)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics.METHODSWe have performed a retrospective study including a total of 179 consecutive patients with gastric cancer (GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. EBV was detected by in situ hybridization for the detection of EBV-encoded small RNAs (EBERs) and EBV latent proteins (LMP1 and LMP2A) were detected by immunohistochemistry.RESULTSThe analysis showed that EBV-associated gastric carcinomas (EBVaGC) represents 8.4% (15/179) of all GC cases, with a significant differential distribution among histological types (P < 0.001): 100% (3/3) of medullary carcinomas, 100% (1/1) of adenosquamous carcinoma, 8.7% (8/92) of tubular adenocarcinomas, 8.0% (2/25) of mixed carcinomas and 2% (1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of EBVaGC in the upper third and middle (cardia, fundus and body) of the stomach (P = 0.041), a significant lower number of regional lymph nodes invasion (P = 0.025) and a tendency for better prognosis (P = 0.222). EBV latent protein expression revealed that all EBVaGC cases were LMP1-negative, nevertheless 6 cases (40%) expressed LPM2A, which reveals that these cases show a distinct EBV-Latency profile (latency II-like).CONCLUSIONEBVaGC represents 8.4% of all GC in the North Region of Portugal. The EBV-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment.

show abstract

Section: Discussionmentioning

confidence: 87%

Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in Portugal

Ribeiro

Oliveira

Malta

et al. 2017

WJG

View full text Add to dashboard Cite

show abstract

Laparoscopic subtotal gastrectomy in morbid obese patients: a valid option to laparoscopic gastric bypass in particular circumstances (prospective study)

et al. 2018

View full text Add to dashboard Cite

show abstract

Epstein-Barr Virus-Associated Gastric Cancer: Old Entity with New Relevance

Sousa¹,

Ribeiro²,

Timóteo³

2021

Infectious Diseases

View full text Add to dashboard Cite

Gastric cancer (GC) represents a major public health issue worldwide, being the fifth most common cancer and one of the leading causes of death by cancer. In 2014, The Cancer Genome Atlas (TCGA) established that tumors positive for Epstein-Barr virus (EBV) are considered a specific subtype of GC (EBVaGC). Several meta-analyses have shown that EBVaGC represents almost 10% of all gastric cancer worldwide, with small differences in the geographic distribution. This tumor subtype has a high potential of being clinically relevant and studies have shown that it has specific features, a better prognosis, and increased overall survival. In this review, we summarize some of the most frequent aspects of EBVaGC, including the specific features of this GC subtype, data regarding the potential steps of EBVaGC carcinogenesis, and perspectives on treatment opportunities.

show abstract

H. PYLORI INFECTION, ENDOSCOPIC, HISTOLOGICAL ASPECTS AND CELL PROLIFERATION IN THE GASTRIC MUCOSA OF PATIENTS SUBMITTED TO ROUX-EN-Y GASTRIC BYPASS WITH CONTENTION RING: a cross sectional endoscopic and immunohistochemical study

Cited by 3 publications

References 23 publications

Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in Portugal

Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in Portugal

Laparoscopic subtotal gastrectomy in morbid obese patients: a valid option to laparoscopic gastric bypass in particular circumstances (prospective study)

Epstein-Barr Virus-Associated Gastric Cancer: Old Entity with New Relevance

Contact Info

Product

Resources

About