Prevalence of Incidental Gallbladder Cancer in a Tertiary-Care Hospital From Pernambuco, Brazil

Martins-Filho, Euclides Dias; Batista, Thales Paulo; Kreimer, Flávio; Martins, Antonio Cavalcanti de Albuquerque; T, Iwanaga; Leão, Cristiano de Souza

doi:10.1590/s0004-28032015000300017

Cited by 13 publications

(13 citation statements)

References 15 publications

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“…We However, it is well established in the literature that GBN is more common in females 12,15,19 , which can be explained by the high prevalence of cholelithiasis in the female population as a result of hormonal factors that decrease the solubility of cholesterol in the bile, facilitating the formation of calculi.…”

Section: Rev Col Bras Cir 46(6):e20192279mentioning

confidence: 99%

“…Figure 1 shows the histological aspects observed in some of the gallbladder histological changes. The diagnosis and early treatment of symptomatic cholelithiasis are pointed as the main form of secondary prevention of this neoplasia 12,14 , since numerous studies have already demonstrated the incidental occurrence of early-stage GBN in patients undergoing elective cholelithiasis 13,19 .…”

Section: Rev Col Bras Cir 46(6):e20192279mentioning

confidence: 99%

“…In two of the six patients, the neoplasm was associated with other histological changes, one with chronic cholecystitis and the other with dysplasia. We also found two cases of pyloric metaplasia, six cases of intestinal metaplasia and 13 cases of gallbladder dysplasia, all considered pre-neoplastic histological changes.DISCUSSIONThe gallbladder cancer is a rare malignancy, with aggressive character and low survival rates.Its largest incidences were reported in women in India (21.5/100,000), in Pakistan (1.8/100,000) and Ecuador (12.9/100,000)12 . Several risk factors have already been associated with gallbladder neoplasia (GBN), such as obesity, multiparity, and chronic Salmonella typhi and Helicobacter pylori infection.…”

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confidence: 98%

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Alterações histológicas da vesícula biliar de doentes submetidos à colecistectomia por colelitíase

Holanda

Júnior

2019

Rev. Col. Bras. Cir.

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RESUMO Objetivo: descrever os achados histológicos das vesículas biliares de pacientes submetidos à colecistectomia e avaliar a presença de fatores associados ao câncer incidental da vesícula. Métodos: estudo descritivo, transversal e observacional de 1.278 exames anatomopatológicos de vesículas biliares oriundas de colecistectomias por colelitíase e de seus respectivos laudos, realizadas no período de janeiro de 2008 a dezembro de 2017. Resultados: o achado anatomopatológico mais frequente foi a colecistite crônica, presente em 1.251 pacientes (97,8%), seguido pela colesterolose em 131 (10,2%). O câncer de vesícula foi identificado em seis pacientes, com prevalência de 0,5% nesta amostra. Houve associação significativa entre a presença de câncer e idade ≥60 anos e com a espessura da parede ≥0,3cm. Conclusão: houve baixa prevalência de câncer de vesícula na população avaliada, maior ocorrência na população idosa e associação de tumor com espessamento da parede vesicular.

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Section: Rev Col Bras Cir 46(6):e20192279mentioning

confidence: 99%

Section: Rev Col Bras Cir 46(6):e20192279mentioning

confidence: 99%

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confidence: 98%

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Alterações histológicas da vesícula biliar de doentes submetidos à colecistectomia por colelitíase

Holanda

Júnior

2019

Rev. Col. Bras. Cir.

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“…The incidental diagnosis in patients electively submitted to cholecystectomy due to cholecystolithiasis in this sample was 0.67%, similar to those published in other Western countries [23][24][25] . Recently, Martins-Filho et al, in a study of the population of the State of Pernambuco, reported prevalence for incidental GBC of 0.34% 26 . Gallbladder cancer affects patients over 50 years of age at approximately 90% of the time, and female.…”

Section: Discussionmentioning

confidence: 99%

Prevalência do câncer de vesícula biliar em pacientes submetidos à colecistectomia: experiência do Hospital de Clínicas da Faculdade de Ciências Médicas da Universidade Estadual de Campinas – UNICAMP

Apodaca-Rueda

Cazzo

De-Carvalho

et al. 2017

Rev. Col. Bras. Cir.

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RESUMO Objetivo: estudar a prevalência do câncer de vesícula biliar em pacientes submetidos à colecistectomia no Hospital de Clínicas da Universidade Estadual de Campinas. Métodos: estudo de prevalência retrospectivo a partir da análise de laudos de espécimes histopatológicos de pacientes submetidos à colecistectomia, no período de janeiro de 2010 a maio de 2015. Resultados: foram analisados 893 laudos de pacientes submetidos à colecistectomia, dos quais 144 de urgência e 749 eletivas (16,2% e 83,8%, respectivamente). Segundo o sexo, 72,8% correspondiam ao feminino e 27,2%, ao masculino. Em 12 pacientes (1,3%) foi evidenciado o diagnóstico de adenocarcinoma de vesícula biliar e, em um (0,1%), o diagnóstico de linfoma não Hodgkin. Dos 13 pacientes com neoplasia, sete (53,8%) apresentaram colecistolitíase associada. Em dois doentes (15,3%) foi constatado pólipo de vesícula biliar. Sete (53,8%) doentes foram operados com a hipótese diagnóstica de neoplasia de vesícula biliar. Conclusão: a prevalência do adenocarcinoma de vesícula biliar no presente estudo foi semelhante à dos estudos ocidentais e o principal fator de risco foi a colecistolitíase, seguido pela presença de pólipos de vesícula biliar.

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“…The presence of gallstones, calcification, inflammation, anomalous pancreatobiliary junction, and polyps are the known risk factors for the development of GC. In addition, advanced age, female gender, obesity, ethnicity (such as Hispanic race) and various geographical regions (such as Chile, Northern India) are also related with higher incidence of GC (3,8,14,15). Goetze (8) defined gallstones and chronic cholecystitis, as the most important risk factors for the development of the GC.…”

Section: Introductionmentioning

confidence: 99%

Incidental Gallbladder Cancer after Laparoscopic Cholecystectomy for Cholelithiasis, and Factors Affecting the Prognosis: A Single-center Experience

Demiryas¹,

Akıncı²,

Kepil³

et al. 2019

Haseki

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Despite surgical and radiological innovations, gallbladder cancer (GC) is usually diagnosed incidentally by the pathological examination of the cholecystectomy specimens, and it is defined as incidental GC (IGC). Methods: Medical files of patients, who underwent cholecystectomy, were analyzed retrospectively. We investigated the relationship between clinicopathological features and survival in patients with IGC. Results: We performed cholecystectomy surgery in 6225 patients in 20 years. Only 21 patients with IGC were included in this study. The distribution of the tumor stages was as follows: in situ cancer (n=1), T1 (n=2), T2 (n=7), and T3 (n=11). Tumor subtypes were identified as adenocarcinoma (n=16), neuroendocrine tumor (n=2), mucinous carcinoma (n=2), and adenosquamous carcinoma (n=1). Advanced ''T stage'', conversion of laparoscopic cholecystectomy to open cholecystectomy (OCC), positive surgical margins, positive lymphovascular invasion and increased levels of pre-operative alkaline phosphatase (ALP) were found to be associated with poor survival. Conclusion: In case of OCC or high preoperative ALP activity in cholelithiasis, IGC should be kept in mind. Pathology report on IGC should give information on all histopathological prognostic features in order to avoid loss of time associated with re-examination of specimens due to absence of sufficient information in the initial pathology report and enable the surgical team to perform re-operation for T1b tumors or more advanced IGC in a timely fashion.

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Prevalence of Incidental Gallbladder Cancer in a Tertiary-Care Hospital From Pernambuco, Brazil

Abstract: This study confirms the poor prognosis of Gallbladder cancer even when incidentally diagnosed following cholecystectomy and supposes a 3-year prevalence estimate of 0.34% for incidental gallbladder cancer in our Center from Pernambuco State, Brazil.

Cited by 13 publications

References 15 publications

Alterações histológicas da vesícula biliar de doentes submetidos à colecistectomia por colelitíase

Alterações histológicas da vesícula biliar de doentes submetidos à colecistectomia por colelitíase

Prevalência do câncer de vesícula biliar em pacientes submetidos à colecistectomia: experiência do Hospital de Clínicas da Faculdade de Ciências Médicas da Universidade Estadual de Campinas – UNICAMP

Incidental Gallbladder Cancer after Laparoscopic Cholecystectomy for Cholelithiasis, and Factors Affecting the Prognosis: A Single-center Experience

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