Influence of Oxidative Stress and Obesity in Patients With Nonalcoholic Steatohepatitis

Leghi, Gabriela E.; Domenici, F; Vannucchi, Hélio

doi:10.1590/s0004-28032015000300014

Cited by 12 publications

(6 citation statements)

References 47 publications

(74 reference statements)

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“…For what concerns biomarkers of OS frequently determined in NAFLD/NASH patients, the most studied ones were quite similar to those previously mentioned for experimental models (Table 2). Overall, the concentrations or activities of these biomarkers were increased in all data examined, although the rise was not significant in some cases [117,[325][326][327]. In addition, many studies, both in human and experimental models of NAFLD/NASH, also measured enzymatic and nonenzymatic liver antioxidant biomarkers [e.g., catalase, SOD, GSH peroxidase (GPx), GSH, thioredoxin reductase (TrxR), α-tocopherol, and ubiquinone], and their activities were decreased in most liver samples, consistently with a loss of their protective abilities due to high OS, while blood, serum, and plasma had more conflicting results [316,324,326,[339][340][341][342][343][344][345] (Tables 3 and 4).…”

Section: Biomarkers Of Oxidative Stress In Nafld/nashmentioning

confidence: 89%

“…Overall, the concentrations or activities of these biomarkers were increased in all data examined, although the rise was not significant in some cases [117,[325][326][327]. In addition, many studies, both in human and experimental models of NAFLD/NASH, also measured enzymatic and nonenzymatic liver antioxidant biomarkers [e.g., catalase, SOD, GSH peroxidase (GPx), GSH, thioredoxin reductase (TrxR), α-tocopherol, and ubiquinone], and their activities were decreased in most liver samples, consistently with a loss of their protective abilities due to high OS, while blood, serum, and plasma had more conflicting results [316,324,326,[339][340][341][342][343][344][345] (Tables 3 and 4). NS: no significant change; SOD: superoxide dismutase; GPx: glutathione peroxidase; GSH: glutathione; GR: glutathione reductase; HF: high-fructose diet; HFD: high-fat diet; OLETF: Otsuka Long-Evans Tokushima Fatty; MCD: methionine/choline-deficient diet; HCD: high-cholesterol diet; ob/ob: obese leptin-deficient; HFMCD: high-fat, methionine choline-deficient diet.…”

Section: Biomarkers Of Oxidative Stress In Nafld/nashmentioning

confidence: 89%

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Oxidative Stress in Non-Alcoholic Fatty Liver Disease

Smirne

Croce

Benedetto

et al. 2022

Livers

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Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it still remains an orphan of adequate therapies. This review highlights the interaction between oxidative stress (OS) and disturbed lipid metabolism. Several reactive oxygen species generators, including those produced in the gastrointestinal tract, contribute to the lipotoxic hepatic (and extrahepatic) damage by fatty acids and a great variety of their biologically active metabolites in a “multiple parallel-hit model”. This leads to inflammation and fibrogenesis and contributes to NAFLD progression. The alterations of the oxidant/antioxidant balance affect also metabolism-related organelles, leading to lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress. This OS-induced damage is at least partially counteracted by the physiological antioxidant response. Therefore, modulation of this defense system emerges as an interesting target to prevent NAFLD development and progression. For instance, probiotics, prebiotics, diet, and fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. The OS and its counter-regulation are under the influence of individual genetic and epigenetic factors as well. In the near future, precision medicine taking into consideration genetic or environmental epigenetic risk factors, coupled with new OS biomarkers, will likely assist in noninvasive diagnosis and monitoring of NAFLD progression and in further personalizing treatments.

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Section: Biomarkers Of Oxidative Stress In Nafld/nashmentioning

confidence: 89%

Section: Biomarkers Of Oxidative Stress In Nafld/nashmentioning

confidence: 89%

Oxidative Stress in Non-Alcoholic Fatty Liver Disease

Smirne

Croce

Benedetto

et al. 2022

Livers

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“…In patients with NAFLD, there is a reduction of the antioxidant capacity in hepatic cells [ 41 ]. Clinically, the enzymatic (CAT, SOD, and GPX) and nonenzymatic antioxidant systems (GSH, TRX, α -tocopherol, and ubiquinone) are decreased in the blood, serum, plasma, and liver [ 17 , 42 – 44 ]. The increased ROS in NAFLD can directly deplete antioxidant molecules and inhibit antioxidant enzymes [ 17 ].…”

Section: Influence Of Oxidative Stress In Nonalcoholic Fatty Livermentioning

confidence: 99%

Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

González

Huerta-Salgado

Orozco-Aguilar

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more aggressive form of the disease characterized by steatosis, inflammatory status, and varying liver degrees fibrosis. NAFLD is the most prevalent chronic liver disease worldwide. The causes of NAFLD are diverse and include genetic and environmental factors. The presence of NASH is strongly associated with cirrhosis development and hepatocellular carcinoma, two conditions that require liver transplantation. The liver alterations during NAFLD are well described. Interestingly, this pathological condition also affects other critical tissues and organs, such as skeletal muscle and even the cardiovascular, renal, and nervous systems. Oxidative stress (OS) is a harmful state present in several chronic diseases, such as NAFLD. The purpose of this review is to describe hepatic and extrahepatic dysfunctions in NAFLD. We will also review the influence of OS on the physiopathological events that affect the critical function of the liver and peripheral tissues.

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“…At the clinical level, a number of antioxidants have been determined in the evaluation of NAFLD/NASH. They include the enzymic antioxidants: CAT, SOD, GPx, GR [47,48,49,50,51,52,53,54], and non-enzymic antioxidants: ascorbic Acid, GSH, α-Tocopherol, Ubiquinone, Thioredoxin (TRX) and Bilirubin [48,49,50,51,52,53,54,55,56,57,58] (Table 5). In general, the activities/concentrations of these antioxidants tend to decrease in NAFLD/NASH patients with a few exceptions where they increased.…”

Section: Antioxidant and Os Markers Measured In Nafld/nashmentioning

confidence: 99%

Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

2019

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Non-alcoholic fatty liver disease (NAFLD) is a term that covers a range of hepatic disorders involving fat deposits in the liver. NAFLD begins with simple steatosis and progresses into non-alcoholic steatohepatitis (NASH) characterised by inflammation, fibrosis, apoptosis, oxidative stress, lipid peroxidation, mitochondrial dysfunction and release of adipokines and pro-inflammatory cytokines. Oxidative stress and antioxidants are known to play a vital role in the pathogenesis and severity of NAFLD/NASH. A number of oxidative stress and antioxidant markers are employed in the assessment of the pathological state and progression of the disease. In this article, we review several biomarkers of oxidative stress and antioxidants that have been measured at clinical and experimental levels. Also included is a comprehensive description of oxidative stress, sources and contribution to the pathogenesis of NAFLD/NASH.

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Influence of Oxidative Stress and Obesity in Patients With Nonalcoholic Steatohepatitis

Cited by 12 publications

References 47 publications

Oxidative Stress in Non-Alcoholic Fatty Liver Disease

Oxidative Stress in Non-Alcoholic Fatty Liver Disease

Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

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