LIPID PROFILE OF CIRRHOTIC PATIENTS AND ITS ASSOCIATION WITH PROGNOSTIC SCORES: a cross-sectional study

Abstract

A reduction in the lipid profile in patients with cirrhosis due to hepatitis C virus infection and/or alcoholism was significantly associated with the Child-Pugh and MELD prognostic markers. These results suggest that the lipid profile may be used as a tool to assist in evaluating liver disease.

Correlation of Fasting Lipid Profile in Patients With Chronic Liver Disease: A Descriptive Cross-Sectional Study in Tertiary Care Hospital

“…In our study, males were significantly more affected than females proving genetic predilection toward gender, results coinciding with outcomes of numerous studies [12,14,15,17,18,20], while opposing with outcomes of countable studies [13,16,19]. The most prevalent etiology leading to the development of cirrhosis in our study was a NAFLD followed by HCV and HBV, synchronizing with outcomes of negligible studies [16,20] while contrasting with findings of various studies [12][13][14][15]17,20]. In our study, the most common comorbidities suffered by individuals were diabetes mellitus followed by HTN and CKD results correlating with few studies [3,16].…”

“…In our study, levels of serum lipid profile including total cholesterol, total TG, VLDLs have their levels declining as the disease progressed from Child-Pugh A to C, finding consistency with many studies [13,15,17,21], while levels of LDL also declined as the disease progressed but another study conducted in similar pattern quoted elevating levels of LDL thus contrasting our results [18]. In our study, levels of HDL had intermediate raise in Child-Pugh class A with decline recorded in Child-Pugh B and again raised in Child-Pugh C, an outcome contrasting with the findings of numerous studies [3,7,13,17,18]. In our study, HDL had no role in determining the severity of the disease, an outcome contrasting with numerous studies [15,17,18,21].…”

“…Patients suffering from cirrhosis not associated with HBV and HCV had more elevated levels of alanine aminotransferase, outcome correlating with a couple of studies [12,16,20]. Serum fasting lipid profile comprising of total cholesterol, VLDL, HDL, and TG levels were slightly decreased in individuals belonging to our study suffering from cirrhosis associated with HBV and HCV outcome coinciding with the results of numerous studies [7,13,15,17,21]. Levels of serum lipid profile in isolated cases of NAFLD is usually elevated [16,20].…”

“…In our study, the age of individuals suffering from CLD ranged from 25 to 50 years with a mean age of 47 years rendering it a disease of middle age coinciding with results of multiple studies [12][13][14][15][16], while our results also contrasted with few studies [17][18][19][20]. In our study, males were significantly more affected than females proving genetic predilection toward gender, results coinciding with outcomes of numerous studies [12,14,15,17,18,20], while opposing with outcomes of countable studies [13,16,19]. The most prevalent etiology leading to the development of cirrhosis in our study was a NAFLD followed by HCV and HBV, synchronizing with outcomes of negligible studies [16,20] while contrasting with findings of various studies [12][13][14][15]17,20].…”

Maternal Consumption of Low-Isoflavone Soy Protein Isolate Confers the Increased Predisposition to Alcoholic Liver Injury in Adult Rat Offspring

“…Particularly, HDL-cholesterol level may be a useful index that evaluates the severity of liver diseases. Serum lipid profile, including total and HDL cholesterol, had a negative correlation with the severity of liver disease [ 35 ]. Here, we observed significantly lower levels of serum total and HDL cholesterol in the SPI/EtOH group compared to the CON/EtOH group.…”