Oral Mucosa Lesions and Oral Symptoms in Inflammatory Bowel Disease Patients

Laranjeira, Nuno; Fonseca, Jorge; Meira, Tânia; Freitas, João; Valido, Sara; Leitão, Jorge

doi:10.1590/s0004-28032015000200006

Cited by 37 publications

(37 citation statements)

References 19 publications

(37 reference statements)

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“…The most frequent lesion found on the sample was ROU, similar result found in the published literature (Plauth et al, 1991;Pittock et al;Scheper & Brand, 2002;Williams et al;Lourenço et al, 2010;Elahi et al;Laranjeira et al, 2015). Even though the literature indicates the relation between these lesions with activation or flare-up of the intestinal pathology (Fatahzadeh), we need to consider also that these lesions are equally frequent in healthy patients (20 % of the population).…”

Section: Discussionsupporting

confidence: 79%

Frequency of Oral Manifestation in Patients with Inflammatory Bowel Disease in Chile

Oviedo

Yañez

Pennacchiotti

2017

Int. J. Odontostomat.

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OVIEDO, C.; YAÑEZ, M. & PENNACCHIOTTI, V.Frequency of oral manifestation in patients with inflammatory bowel disease in Chile. Int. J. Odontostomat., 11(3):267-271, 2017. SUMMARY:Inflammatory bowel disease (IBD) is an autoinflammatory chronic disorder of the gastrointestinal tract with a dysregulated immune response, being Crohn's Disease (CD) and Ulcerative Colitis (UC) the two main conditions. In literature the extra intestinal manifestations associated with IBD have been well documented. However, in our country, there are no studies about the oral manifestations. Having this information, is fundamental in order to optimize resources involved in diagnosis and treatment in a multidisciplinary level. Descriptive observational cross-sectional study, with a non-probabilistic sample for convenience with patients diagnosed with IBD belonging to the "CD-UC Group". In a period of four months the intraoral exam, diagnosis, and description of the lesions according location, type of illness, age, and sex were carried out. Thirty (30) patients (23 UC and 7 CD) filled the criteria of inclusion, 30 % men and 70 % women. 11 patients presented at least one oral lesion, being recurrent oral ulcer the most frequent, and two more specific lesions (macrocheilia and corrugated lesion). Of these patients, 37 % presented at least one oral lesion, being the most frequent one recurrent oral ulcer (ROU).KEY WORDS: oral manifestations, inflammatory bowel disease, Crohn's disease, ulcerative colitis, recurrent oral ulcer.

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Section: Discussionsupporting

confidence: 79%

Frequency of Oral Manifestation in Patients with Inflammatory Bowel Disease in Chile

Oviedo

Yañez

Pennacchiotti

2017

Int. J. Odontostomat.

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“…10 Oral manifestations of CD are observed in 8% to 10% of patients and may be considered specific or unspecific. [11][12][13] Specific manifestations are comparatively rare and sometimes precede gastrointestinal lesions, which may evolve with time. These manifestations include cobblestoned oral mucosa, granular gingival swelling of hyperplastic aspect, labial swelling accompanied by vertical fissures, and deep and linear ulcers associated with hyperplastic mucosa folds on the vestibule fold.…”

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confidence: 99%

“…Pyostomatitis vegetans is the only condition that is more prevalent in UC patients, compared to individuals with CD. 11,12,14,19,20 Due to the high prevalence of oral UC, knowledge about these conditions is a useful tool in differential diagnosis, since an improvement in the clinical picture concerning the primary disease will influence the recovery of oral health. Moreover, considering that oral lesions may precede gastrointestinal signs and symptoms, the dentist may play an important role in the early diagnosis of IBD.…”

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confidence: 99%

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Pereira

Munerato

2016

Clinical Medicine & Research

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Inflammatory bowel diseases (IBD) are known as chronic inflammatory disorders of the digestive tract, represented mainly by Crohn's disease (CD) and ulcerative colitis (UC). Among the main oral manifestations of IBD are cobblestoning of the oral mucosa, labial swellings with vertical fissures, pyostomatitis vegetans, angular cheilitis, perioral erythema, and glossitis. In this sense, understanding these nosological entities by dentists would help reach early and differential diagnosis. Thus, two case reports are presented and discussed based on theoretical references obtained by a literature review. The first case report refers to an adult patient whose IBD diagnosis was established after stomatological assessment. The second case was a patient with CD diagnosed in childhood with characteristic oral lesions.

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“…41 In a tertiary centre case-control study conducted in Portugal, consisting of 113 patients with previously diagnosed IBD and 58 healthy controls, there was a significantly increased prevalence of oral symptoms when compared with the control that did not have IBD (54.9% vs. 24.3%, P = 0.011). 42 Oral symptoms were also present in a greater proportion within the active phase cohort than in the remission cohort (70.6% vs. 52.1%, P = 0.001). Moreover, aphthous ulcers had a substantially increased presence within the active phase when compared with remission (35.3% vs. 4.2%, P <0.001).…”

Section: Introductionmentioning

confidence: 93%

Inflammatory bowel disease and oral health

Chandan

Thomas

2017

BDJ Team

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Risk factors involved in IBDIBD is thought to result from inappropriate and ongoing activation of the mucosal immune system facilitated by defects in both the intestinal epithelium and mucosal immune system. 5 There are both genetic and environmental factors implicated in the aetiology of IBD. 6 Although traditionally associated with the developed world, recent epidemiological studies suggest an increasing incidence in rapidly developing countries, especially in South-East Asia. 7 In addition, the increased risk of IBD in the immigrant populations in the West suggests environment has a role in the development of IBD. 8 Genetic Detailed genetic mapping has identified specific genetic changes on chromosome 16 carried in families which appear linked to CD, however no significant changes have been mapped as of yet to UC. 9,10 Specifically, variants of the NOD2 gene provide the strongest association with susceptibility to CD. NOD2 plays a key role in regulating the gut mucosal barrier involving, specifically, the microbiota, as well as the related response by the innate and adaptive immune system. The IBDchip European Project showed NOD2 has been implicated in ileal location colitis with stenosing and penetrating disease behaviour. 11 A genome wide association study has also identified a strong link between the IL23R gene and CD. 12 The gene in particular codes for interleukin 23 that plays a role in regulating innate immunity within the intestine. 13 Cigarette smoking Unusually, cigarette smoking is associated with decreased rates of incidence of UC and has been associated with protective features to prevent further flare-ups of the condition 14-19 such as relapses, 20 ©SEBASTIAN KAULITZKI/Science Photo Library/Getty J. S. Chandan 1 and T. Thomas 1 summarise the treatments for inflammatory bowel disease (IBD) and how anti-inflammatory medications can have side effects that affect the oral cavity.

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Oral Mucosa Lesions and Oral Symptoms in Inflammatory Bowel Disease Patients

Abstract: Oral mucosa's lesions and oral symptoms were positively associated with Inflammatory Bowel Disease, mainly during disease activity periods and conceivably, associated with corticosteroid and immunosuppressant therapy.

Cited by 37 publications

References 19 publications

Frequency of Oral Manifestation in Patients with Inflammatory Bowel Disease in Chile

Frequency of Oral Manifestation in Patients with Inflammatory Bowel Disease in Chile

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Inflammatory bowel disease and oral health

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