RESEARCH IN INFLAMMATORY BOWEL DISEASES IN LATIN AMERICA: a challenge ahead

Kotze, Paulo Gustavo

doi:10.1590/s0004-28032014000400001

Cited by 7 publications

(8 citation statements)

References 5 publications

(6 reference statements)

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“…Many reports show that the incidence of CIUC in Latin America is increasing, perhaps as a result of changes in lifestyle and exposure to environmental factors. In some cases, it is comparable to the reports in Europe and the USA during the 1970s and 1980s, 13 with this reflecting that even when Latin America is the area with the lowest incidence of CIUC in the world, it could reach an incidence and prevalence similar to those in other areas of the world in the coming years. 14 However, improvements in diagnostic tools and medical therapy options could help change the clinical course and outcomes of the disease.…”

Section: Discussionsupporting

confidence: 78%

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Yamamoto‐Furusho¹,

Sánchez-Morales²

2023

GMM

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Background: Chronic idiopathic ulcerative colitis (CIUC) is a disease with multifactorial chronic inflammation of the colonic mucosa. Its prevalence ranges from 37.5-250/100,000 in North America to 10-500/100,000 in Europe. In Mexico, there are studies that show an increase in the frequency of new cases. The purpose of this work was to identify possible changes in CIUC behavior in a referral hospital. Methods: New ulcerative colitis (UC) cases confirmed by histopathology from January 2007 to December 2014 were included. Clinical and demographic data were collected through the review of medical records and direct interview in order to compare them with a previous study conducted at the same institution from January 1986 to December 2006. Results: A total of 189 patients were included. Mean number of UC annual new cases was 23.6. The study included 95 male patients (50 %) and 94 female patients (50 %), with an average age of 44.6 years at diagnosis. The frequency of pancolitis was 77 %, in comparison with 59 % in the previous period. Extra-intestinal manifestations (EIM) were present in 55.8 % and colectomies in 5.2 %. Conclusion: There is a lower mean of annual new cases; however, some characteristics of the disease have changed over time: there is an increased frequency of pancolitis and EIM, as well as a decrease in the rate of colectomies.

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Section: Discussionsupporting

confidence: 78%

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Yamamoto‐Furusho¹,

Sánchez-Morales²

2023

GMM

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“…Those published rates are lower than those found in the present study, with incidence of UC between 2.2 and 4.3 new cases/100,000 inhabitants/year and of CD between 0.8 and 2.0 new cases/100,000 inhabitants/year. 21 , 22 Despite the low prevalence of IBD in São Paulo, as compared to North America and Europe, the similarity of incidence rates allows us to infer that sometime in the future the prevalence data may equalize, considering the trend toward stabilization or even reduction of the incidence rates of IBD in developed countries that was demonstrated in the systematic review of Ng et al 18 …”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease epidemiology in São Paulo State, Brazil

Gasparini¹,

Sassaki²,

Saad-Hossne³

2018

CEG

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PurposeThis study aimed to estimate the incidence and prevalence of inflammatory bowel disease (IBD) in São Paulo, Brazil, for 2012–2015.Patients and methods:This observational, descriptive, and cross-sectional study included 22,638 IBD patients out of 43,046,555 inhabitants, who had initiated their treatment through the Governmental Program of the Brazilian Unified National Health System between the years of 2012 and 2015. The onset of the disease (used to determine incidence) was established as the date of the patient’s initial registration in the Governmental Program with a diagnosis for Crohn’s disease (CD) or ulcerative colitis (UC). Every patient registered in the system as of December 2015 was included in determining the prevalence. The demographic and clinical data, such as age and sex, were collected for each patient. Statistical analysis included mean and SD, absolute and percentage frequencies, and Pearson’s chi-squared test (c2). The incidence and prevalence rates were calculated based on the estimated annual population of the State of São Paulo.ResultsThe study population consisted of 10,451 (46.16%) CD patients and 12,187 (53.84%) UC patients. The mean age was 42.66 (SD±16.2) years for the CD group and 47.87 (SD±16.6) years for the UC group. There was a predominance of females corresponding to 59.70% of the study population (female:male =1.48:1.00; P<0.0001). The incidence of IBD was 13.30 new cases/100,000 inhabitants per year, while the overall prevalence was 52.6 cases/100,000 inhabitants.ConclusionThis population-based study demonstrated a stability in IBD incidence rates and an increase in IBD prevalence rates in São Paulo state between 2012 and 2015. The IBD incidence and prevalence rates were comparable to European countries, with a higher occurrence in the female participants.

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“…In the United States, incidence rates range from 2.2 to 19.2 cases/100,000 person-years for UC and from 3.1 to 20.2 cases/100,000 personyears for CD [5,6]. Recently, efforts have been made to describe IBD in some developing regions such as Latin America, showing differences in the burden of the disease among countries [7]. Environmental factors such as socioeconomic status, exposure to infections, use of antibiotics, and issues of hygiene might help explain the epidemiological differences between populations [6].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Bowel Disease in Latin America: A Systematic Review

Calderón

Minckas

Nuñez

et al. 2018

Value in Health Regional Issues

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Background: Inflammatory bowel disease (IBD) is the name given to two inflammatory diseases of the colon and/or small intestine: Crohn disease (CD) and ulcerative colitis (UC). There is no information summarizing the complete body of evidence about IBD in developing regions, including Latin America. Objectives: To estimate the burden of IBD in Latin America. Methods: We conducted a systematic review searching published and unpublished studies on major international and regional databases from January 2000 to September 2015. Outcomes considered were incidence, prevalence, mortality, hospitalization attributable, treatment patterns, comparative effectiveness, patient-reported outcomes, and adherence to treatment. Pairs of reviewers independently selected, extracted, and assessed the risk of bias of the studies. Discrepancies were solved by consensus. Results: We retrieved 3445 references, finally including 25 studies. Only 19% of the observational studies had a low risk of bias for participant selection and 60% were based on registries. The incidence ranged from 0.74 to 6.76/100,000 person-years for UC and from 0.24 to 3.5/100,000 person-years for CD. The prevalence rate ranged from 0.99 to 44.3/100,000 inhabitants for UC and 0.24 to 16.7/100,000 inhabitants for CD. Mortality rates ranged from 0.60 to 1.02 for UC and from 0.23 to 0.40 for CD. Patient-reported outcomes showed a decrease in quality of life associated with depression and anxiety and correlated with the time of diagnosis. The most frequently used medication in the studies was mesalazine. Conclusions: The burden of IBD in Latin America seems to be important, but there is a considerable gap of high-quality evidence in the region.

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RESEARCH IN INFLAMMATORY BOWEL DISEASES IN LATIN AMERICA: a challenge ahead

Cited by 7 publications

References 5 publications

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Inflammatory bowel disease epidemiology in São Paulo State, Brazil

Inflammatory Bowel Disease in Latin America: A Systematic Review

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RESEARCH IN INFLAMMATORY BOWEL DISEASES IN LATIN AMERICA: a challenge ahead

Cited by 7 publications

References 5 publications

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital

Inflammatory bowel disease epidemiology in S&atilde;o Paulo State, Brazil

Inflammatory Bowel Disease in Latin America: A Systematic Review

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Inflammatory bowel disease epidemiology in São Paulo State, Brazil