Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Oliveira, Juliana Ghisleni de; Ferreira, Cristina Helena Targa; Camerin, Anna Carolina Saraiva; Rota, C.; Meurer, Luíse; Silveira, Themis Reverbel da

doi:10.1590/s0004-28032014000300003

Cited by 9 publications

(11 citation statements)

References 32 publications

(58 reference statements)

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“…Regarding the distribution of genders by age group, the result found reinforces data already existing in the current literature, which does not observe significant statistical difference between genders (11,14,15) .…”

Section: Discussionsupporting

confidence: 88%

Time Trends of Helicobacter Pylori Prevalence in Itajaí - Sc: A Retrospective Study of 25 Years Based on Endoscopic Database

Ferrari

Dutra

Zanardi

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: The bacterium Helicobacter pylori is strongly associated with the development of gastric adenocarcinoma. Currently, the prevalence in developed countries is 40%, but this value increases considerably in developing countries, which can reach rates bigger than 90%. OBJECTIVE: The objective of this study was to determine the mean and annual prevalence of Helicobacter pylori infection in patients from Itajaí during the period from July 1992 to April 2016, as well as the gender and age groups most affected. METHODS: After consent of the clinical director of the Gastroclinica Itajaí and confidentiality commitment about the research, the database of the Endoscopy Service of the clinic was evaluated. All the patients who underwent their first upper digestive endoscopy with urease test and/or histological analysis were included. The data were submitted to statistical analysis of prevalence by gender, age group and years of study, with subsequent correction through the confidence interval. RESULTS: The mean prevalence of Helicobacter pylori infection thru all years of study was 50.07%. With the calculation of the annual prevalences, it was evident the gradual reduction of infection in the population of Itajaí, that was 81.3% in 1992, declining to 33% in the year of 2016. When classifying the prevalence of infection by gender, it was higher in males (53.59%), and gender distribution by age group showed no statistically significant difference among genders between the ages of 40 and 80 years. In relation to the age group, the highest prevalence was in the group between 40 and 49 years. CONCLUSION: Although this study is retrospective and based on endoscopic database analysis, without access to clinical data of patients such as prior use of proton pump inhibitor and antibiotics to endoscopy, its results are important because they may reflect the current panorama of Helicobacter pylori infection in the city under study, where it has been presenting a gradual reduction of prevalence over the years, with current rates similar to that of developed countries (33%). Future studies are needed to confirm our data.

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Section: Discussionsupporting

confidence: 88%

Time Trends of Helicobacter Pylori Prevalence in Itajaí - Sc: A Retrospective Study of 25 Years Based on Endoscopic Database

Ferrari

Dutra

Zanardi

et al. 2019

Arq. Gastroenterol.

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“…This was supported by studies done by Abdel Razak, Ozbey et al, Oliveira et al who also observed pain abdomen as a common symptom in 67.5%, 57.4%, 34.6% cases, respectively. (2,7,8) Gastrointestinal bleeding was observed in studies by Oliveira et al (13.4%), Ozbey et al (11.9%), Motamed et al (9.8%), K Thakkar (5.8%) whereas we did not see any child with complaints of gastrointestinal bleed. (2,8,9,10) Under nutrition and growth retardation was observed in dyspeptic children by Ozbey et al (21.8%) and K Thakkar (2.4%).…”

Section: Discussioncontrasting

confidence: 51%

“…Chi-square value = 168.941 with a p <0.0001. (1,2) Lymphocytic infiltration was mild-to-moderate in 28 (74%) and high in 10 cases (26%) ( Figure 6). Neutrophilic infiltration was noted in four cases (10%), mildto-moderate in three cases (8%) and high in one case (3%).…”

Section: Gross Endoscopic Findingsmentioning

confidence: 96%

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Endoscopic and Histopathologic Changes in Children With Chronic Dyspepsia in a Rural Medical College Hospital in Melmaruvathur- Tamilnadu

Padma¹,

Sumathi²,

Nagendram³

et al. 2016

jebmh

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INTRODUCTION Chronic pain abdomen and dyspepsia is the most common presenting symptoms in the Paediatric Outpatient Department (OPD) after respiratory illnesses. It is increasing alarmingly both in the paediatric and adult population. We, therefore carried out a cross-sectional study among children with chronic dyspepsia aged between 5 to 15 years attending Paediatric OPD in a rural medical college hospital, Melmaruvathur, Tamilnadu, South India. OBJECTIVE To evaluate the gastroduodenal morbidity in children presenting to the paediatric department of a rural medical college hospital with chronic dyspeptic symptoms. METHODS Forty six children between the age group of 5 to 15 years with chronic dyspeptic symptoms of at least one month duration were evaluated for their symptom profile, epidemiological profile, nutritional status, endoscopic appearance and histopathological changes. Data analysis was done using SPSS version 18. RESULTS Of the 46 children studied, 43% were between the age group of 5-10 years and 70% were female children. Pain abdomen lasting for more than at least one month was the most common finding (93%) observed. Other common symptoms in the order of decreasing frequency were early satiety (87%), poor appetite (76%), nausea (57%) and not thriving (57%). History of loss of appetite was significantly associated with chronic dyspepsia with an odds ratio of 68.9394 and 95% confidence interval 26.62 to 178.54, p value of <0.0001. Most of the children belonged to lower income group predominantly of a rural background. 33 (72%) children had under nutrition as per IAP classification. 10 (30%) Grade I, 15 (45%) Grade II and eight (24%) had Grade III malnutrition. 26 children (57%) had abnormal endoscopic findings. Antral mucosal biopsy done showed chronic lymphocytic gastritis in 44 (96%) cases. 38 of these 44 (86%) were H. pylori positive. H. pylori positivity in chronic dyspepsia was highly statistically significant with a p value of 0.0001 CONCLUSION The incidence of dyspepsia is common among children between the age group of 5-10 years with a female preponderance. The predominant symptom noted among these rural children are abdominal pain and loss of appetite. Multiple gastric erosions is the common finding observed endoscopically and H. pylori associated gastritis is the overwhelming finding in our children with chronic dyspepsia.

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“…The prevalence of cagA ‐positive H. pylori was 29.6%. There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histologic features of the patients infected with cagA ‐positive strains as compared with those infected with cagA ‐negative strains .…”

Section: Pathophysiologymentioning

confidence: 82%

Helicobacter pylori Infection in Pediatrics

Roma

Miele

2015

Helicobacter

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This review includes the main pediatric studies published from April 2014 to March 2015. The host response of Treg cells with increases in FOXP3 and TGF‐β1 combined with a reduction in IFN‐γ by Teff cells may contribute to Helicobacter pylori susceptibility in children. Genotypic variability in H. pylori strains influences the clinical manifestation of the infection. Helicobacter pylori infection is associated with variables indicative of a crowded environment and poor living conditions, while breast‐feeding has a protective effect. Intrafamilial infection, especially from mother to children and from sibling to sibling, is the dominant transmission route. Studies showed conflicting results regarding the association between H. pylori infection and iron deficiency anemia. One study suggests that H. pylori eradication plays a role in the management of chronic immune thrombocytopenic purpura in H. pylori‐infected children and adolescents. The prevalence of H. pylori was higher in chronic urticaria patients than in controls and, following H. pylori eradication, urticarial symptoms disappeared. An inverse relationship between H. pylori infection and allergic disease was reported. Antibiotic resistance and insufficient compliance to treatment limit the efficacy of eradication therapy. Sequential therapy had no advantage over standard triple therapy. In countries where H. pylori infection is prevalent, studies focusing on virulence factors and antibiotic susceptibility may provide anticipation of the prognosis and may be helpful to reduce morbidity and mortality.

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Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Cited by 9 publications

References 32 publications

Time Trends of Helicobacter Pylori Prevalence in Itajaí - Sc: A Retrospective Study of 25 Years Based on Endoscopic Database

Time Trends of Helicobacter Pylori Prevalence in Itajaí - Sc: A Retrospective Study of 25 Years Based on Endoscopic Database

Endoscopic and Histopathologic Changes in Children With Chronic Dyspepsia in a Rural Medical College Hospital in Melmaruvathur- Tamilnadu

Helicobacter pylori Infection in Pediatrics

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