RISK OF INFERTILITY IN PATIENTS WITH CELIAC DISEASE: a meta-analysis of observational studies

Lasa, Juan S.; Zubiaurre, Ignacio; Soifer, Luis

doi:10.1590/s0004-28032014000200014

Cited by 30 publications

(15 citation statements)

References 28 publications

(36 reference statements)

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“…12, 13 . However, another report found that women with celiac disease did not have an overall higher risk of fertility problems than the general population.…”

Section: Clinical Featuresmentioning

confidence: 99%

Advances in Diagnosis and Management of Celiac Disease

et al. 2015

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Celiac disease is an autoimmune disorder induced by dietary gluten in genetically predisposed individuals. It has a prevalence of ∼1% in many populations worldwide. New diagnoses have increased substantially, due to increased awareness, better diagnostic tools, and probable, real increases in incidence. The breadth of recognized clinical presentations continues to expand, making the disorder highly relevant to all physicians. Newer diagnostic tools, including serologic tests for antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptide, greatly facilitate diagnosis. Tests for celiac-permissive HLA DQ2 and DQ8 molecules are useful in defined clinical situations. Celiac disease is diagnosed by histopathologic examination of duodenal biopsies. However, according to recent controversial guidelines, a diagnosis can be made without biopsy in certain circumstances, especially for children. Symptoms, mortality, and risk for malignancy can each be reduced by adherence to a gluten-free diet. This treatment is a challenge, however, as the diet is expensive, socially isolating, and not always effective in controlling symptoms or intestinal damage. Hence, there is increasing interest in developing non-dietary therapies.

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“…12, 13 . However, another report found that women with celiac disease did not have an overall higher risk of fertility problems than the general population.…”

Section: Clinical Featuresmentioning

confidence: 99%

Advances in Diagnosis and Management of Celiac Disease

et al. 2015

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“…Most of them used antigliadin, antitransglutaminase or antiendomysium antibodies to screen the patients enrolled in their studies, and biopsy was reserved for those patients with positive serology. Interestingly, most of them fail to find a statistically significant increased prevalence of CD in women with unexplained infertility -a finding that becomes significant when pooled analysis is performed [12].…”

Section: Female Infertility In Celiac Diseasementioning

confidence: 99%

Celiac Disease and the Risk of Infertility

Olivera¹,

Lasa²

2016

IJCD

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Celiac Disease is a chronic inflammatory disease, caused by an abnormal immune response triggered by intestinal exposure to dietary gluten, the protein fraction of wheat, rye and barley, in genetically susceptible individuals. Among atypical presentations of Celiac Disease, reproductive disorders and adverse pregnancy outcomes have been reported. Infertility is defined as the impossibility of conceiving after 12 months of unprotected intercourse. It can be related to both male and female factors, with the latter subdivided into ovarian, tubal, endometrial or unexplained causes. Celiac Disease has been related to infertility, but the evidence is inconclusive. In this review, we discuss the effect of Celiac Disease in both male and female fertility, as well as the possible mechanisms that may be involved.

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“…Undiagnosed and untreated celiac disease can be associated with miscarriages and infertility [175,176], and interestingly, TG2-bound celiac patient IgA has been detected in the wall of decidual blood vessels and on the surface of the chorionic villous structures [147]. It has been proposed that these antibodies might alter TG2 activity [177] and impair nutrient import [147].…”

Section: The Role Of Celiac Patient Antibodies In the Induction Of Exmentioning

confidence: 99%

Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review

Rauhavirta

Hietikko

Salmi

et al. 2016

Clinic Rev Allerg Immunol

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Celiac disease is a common inflammatory disorder with a prevalence of 1-2 % in which a distinct dietary wheat, rye, and barley component, gluten, induces small-bowel mucosal villous atrophy, crypt hyperplasia, and inflammation. The small-bowel mucosal damage can be reversed by a strict lifelong gluten-free diet, which is currently the only effective treatment for the condition. A key player in the pathogenetic process leading to the enteropathy is played by a protein called transglutaminase 2 (TG2), which is able to enzymatically modify gluten-derived gliadin peptides. The TG2-catalyzed deamidation of the gliadin peptides results in their increased binding affinity to the disease-predisposing human leukocyte antigen (HLA) DQ2 and DQ8 molecules, thus enabling a strong immune response to be launched. Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. By virtue of its transamidation capacity, TG2 is also able to cross-link gliadin peptides to itself, this resulting in the generation of TG2-gliadin peptide complexes whose presence might provide an explanation for the generation of the TG2 autoantibodies characteristic of celiac disease. Due to their excellent specificity for the disorder, the TG2-targeted autoantibodies are widely used in the diagnostics as a first-line test to select patients for gastrointestinal endoscopy. More recently, it has come to be appreciated that these autoantibodies and also the TG2-specific B cells might play an active role in the disease pathogenesis. In this review, we assess the role of TG2, TG2-specific B cells, and autoantibodies in celiac disease.

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RISK OF INFERTILITY IN PATIENTS WITH CELIAC DISEASE: a meta-analysis of observational studies

Cited by 30 publications

References 28 publications

Advances in Diagnosis and Management of Celiac Disease

Advances in Diagnosis and Management of Celiac Disease

Celiac Disease and the Risk of Infertility

Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review

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