Low Dose Capsule Based 13c-Urea Breath Test Compared With the Conventional 13c-Urea Breath Test and Invasive Tests

Mattar, Rejane; Villares, Cibele Aparecida; Marostegam, Priscila Faria França; Chaves, Cleuber Esteves; Pinto, Vanusa Barbosa; Carrilho, Flair José

doi:10.1590/s0004-28032014000200012

Cited by 8 publications

(8 citation statements)

References 27 publications

(48 reference statements)

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“…A recently published study describes a residual gas analyser-based mass spectrometry approach with possible point-of-care application [ 39 ]. A further study has evaluated a low dose capsule-based UBT approach compared to conventional UBT and invasive tests [ 40 ]. This approach seems to be superior to the conventional UBT in terms of sensitivity and specificity, resulting in 100% sensitivity and specificity but depending on the time of sample collection.…”

Section: Non-invasive Methodsmentioning

confidence: 99%

Diagnosis of Helicobacter pylori: Changes towards the Future

2015

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Since the first evidence demonstrating the dramatically high incidence of H. pylori infection and the subsequent medical challenges it incurs, health management of H. pylori infection has been a high priority for health authorities worldwide. Despite a decreasing rate of infection in western countries, prevalence of H. pylori infection in developing and in some industrial countries is still very high. Whereas treatment and vaccination against H. pylori is a contemporary issue in medical communities, selective treatment and prior high-throughput screening of the subject population is a major concern of health organizations. So far, diagnostic tests are either elaborative and require relatively advanced medical care infrastructure or they do not fulfill the criteria recommended by the Maastricht IV/Florence consensus report. In this review, in light of recent scientific studies, we highlight current and possible future approaches for the diagnosis of H. pylori. We point out that novel non-invasive tests may not only cover the requirements of gold standard methods in H. pylori detection but also offer the potential for risk stratification of infection in a high throughput manner.

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Section: Non-invasive Methodsmentioning

confidence: 99%

Diagnosis of Helicobacter pylori: Changes towards the Future

2015

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“…This bacterium is biochemically characterized as being urease-dependent, being of importance to invasive and noninvasive diagnostic tests 9 , 15 , 18 , 19 , 22 , 24 , 25 , 27 , 28 , 29 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter Pylori Ten Years Ago Compared to the Current Prevalence in Patients Undergoing Upper Endoscopy

Frugis

Czeczko

Malafaia

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. The literature lacks studies that show the change of its prevalence in the same population over time. Aim: To compare the prevalence of H. pylori in 10 years interval in a population that was submitted to upper endoscopy in the same endoscopy service. Method: Observational, retrospective and cross-sectional study comparing the prevalence of H. pylori in two samples with 10 years apart (2004 and 2014) who underwent endoscopy with biopsy and urease. Patients were studied in three consecutive months of 2004, compared to three consecutive months of 2014. The total number of patients was 2536, and 1406 in 2004 and 1130 in 2014. Results: There were positive for H. pylori in 17 % of the sample as a whole. There was a significant decrease in the prevalence from 19.3% in 2004 to 14.1% in 2014 (p<0.005). Conclusion: There was a 5.2% reduction in the prevalence of H. pylori comparing two periods of three consecutive months with 10 years apart in two equivalent population samples.

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“…This test has been validated and performed since 1998 in the adult population of Belo Horizonte City for initial diagnosis of H. pylori infection and/or post-treatment assessment 8 . However, the use of this test throughout the country remains unacceptably restricted to a few university centers 8 - 11 . One of the main barriers regarding the use of this test is the difficulty in obtaining the labeled isotope, as the technology for carbon separation (i.e., 13 C and 12 C) has not been transferred by the countries that developed it due to economic reasons and strategic interests.…”

Section: Introductionmentioning

confidence: 99%

Performance of the 13C-urea breath test for the diagnosis of H. pylori infection using a substrate synthesized in Brazil: A preliminary study

Coelho¹,

Sant'Ana²,

Oliveira³

et al. 2018

Clinics

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OBJECTIVE:The 13C-urea breath test is the main non-invasive test for the diagnosis of Helicobacter pylori infection. The availability of this test throughout the country is limited, mainly due to the difficulty in obtaining the labeled isotope from abroad. Recently, researchers from the Nuclear Energy Center in Agriculture at the University of São Paulo (CENA/USP) succeeded in synthesizing 13C-enriched urea for Helicobacter pylori diagnosis. The aim of the study was to compare the performance of the 13C-urea breath test using 13C-urea acquired abroad with that of a test using 13C-urea synthesized in Brazil.METHOD:Sixty-four dyspeptic patients participated in the study (24 men and 40 women). Initially, the patients performed the 13C-urea breath test using the imported substrate (Euriso-Top, France). Seven to fourteen days later, all the patients repeated the test using the Brazilian substrate. The samples from both examinations were processed in an infrared isotope analyzer (IRIS, Wagner Analisen Technik, Germany), and all delta over baseline (DOB) [%] values above four were considered positive results.RESULTS:Twenty-seven patients (42%) exhibited negative results for Helicobacter pylori infection, and thirty-seven patients (58%) exhibited positive results when tested using the foreign substrate (gold standard). There was a 100% concordance regarding the presence or absence of infection when the gold standard results were compared with those obtained using the Brazilian substrate.CONCLUSIONS:Similar performance in the diagnosis of Helicobacter pylori infection was demonstrated when using the 13C-urea breath test with the Brazilian 13C-urea substrate and the test with the substrate produced abroad. This validation represents an important step toward increasing the availability of the 13C-urea breath test throughout the country, which will have a positive influence on the management of Helicobacter pylori infection.

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Low Dose Capsule Based 13c-Urea Breath Test Compared With the Conventional 13c-Urea Breath Test and Invasive Tests

Cited by 8 publications

References 27 publications

Diagnosis of Helicobacter pylori: Changes towards the Future

Diagnosis of Helicobacter pylori: Changes towards the Future

Prevalence of Helicobacter Pylori Ten Years Ago Compared to the Current Prevalence in Patients Undergoing Upper Endoscopy

Performance of the 13C-urea breath test for the diagnosis of H. pylori infection using a substrate synthesized in Brazil: A preliminary study

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