THE PREVALENCE AND CLINICAL CHARACTERISTICS OF PRIMARY HEADACHE IN IRRITABLE BOWEL SYNDROME: a subgroup of the functional somatic syndromes

Soares, Rosa Leonôra Salerno; Moreira-filho, P.F; Maneschy, Carolina Possidente; Breijão, Julia Fumian; Schmidte, Nathan Mielke

doi:10.1590/s0004-28032013000400008

Cited by 6 publications

(5 citation statements)

References 38 publications

(70 reference statements)

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“…Watson et al 23 postulated a hormonal cause relating headache and IBS, since 50% of their IBS patients had headache. A neuroendocrine mechanism as a common pathophysiological mechanism underlying IBS and migraine was also postulated by Soares et al 24 Cole et al 16 found that the likelihood of migraine was 40–80% higher in subjects with IBS than in those without IBS.…”

Section: Resultsmentioning

confidence: 69%

Is there an Association between Migraine and Gastrointestinal Disorders?

2017

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Migraine is a primary episodic headache disorder that represents a substantial burden and disability worldwide. Its pathogenesis is multifactorial and remains hitherto poorly elucidated. An interesting but less-well-known association is that between migraine and gastrointestinal disorders. We have reviewed the literature for relevant papers reporting on the clinical association between migraine and gastrointestinal symptoms. Several studies have shown different gastrointestinal diseases to be associated with migraine, but the underlining pathophysiology remains elusive. The data gathered and analyzed have shown great variability across studies, making it impossible to draw definitive conclusions. Further research is required to elucidate this potential relationship. An understanding of the relationship between migraine and gastrointestinal disorders is of great clinical importance for prompt diagnosis and treatment.

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Section: Resultsmentioning

confidence: 69%

Is there an Association between Migraine and Gastrointestinal Disorders?

2017

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“…Comorbidities or extra-intestinal symptoms are frequently in a sub-type of IBS patients. Some pain and hypersensitivity events in IBS patients, like chronic pelvic pain[ 39 ], primary headache[ 40 ] and higher reactivity to food antigens[ 41 ], might be also related to purinergic signaling. More research needs to be done to figure out whether there are connections between P2 receptors and these events, and it might help to understand the mechanism of P2Y1R involved in visceral pain in IBS.…”

Section: Discussionmentioning

confidence: 99%

P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome

Cheng

Zhang

et al. 2017

WJG

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AIMTo evaluate the role of P2Y1R in visceral hypersensitivity in rats with experimental irritable bowel syndrome.METHODSA rat model of irritable bowel syndrome was generated by intra-colonic administration of acetic acid (AA) and assessed by histology and myeloperoxidase (MPO) activity assay. Then P2Y1R expression in the colonic tissue was detected by Western blot. In order to explore the regulatory role of P2Y1R in visceral hypersensitivity, an agonist (MRS2365) and an antagonist (MRS2179) of P2Y1R were intra-colonically administered and effects were tested through a colorectal distension test. The abdominal withdrawal reflex and abdominal electromyography were tested during the course.RESULTSModel assessment tests showed an obvious inflammatory reaction that appeared on the 2nd d after the AA injection, and the inflammatory reaction gradually recovered and almost disappeared on the 7th d. The model finished on day 8 and showed a clear feature of IBS that had no organic lesion. The average expression of P2Y1R was significantly higher in the AA group than in the naïve group (0.319 ± 0.02 vs 0.094 ± 0.016, P < 0.001). MRS2365 could effectively raise the colonic hypersensitivity status at intervention doses of 10 (AUC value from 0.30 ± 0.089 to 1.973 ± 0.127 mv·s, P < 0.01) and 100 μmol/L (AUC value from 0.290 ± 0.079 to 1.983 ± 0.195 mv·s, P < 0.01); MRS2179 could effectively reduce the hypersensitivity status at intervention dose of 100 μmol/L (from a mean baseline AUC value of 1.587 ± 0.099 mv·s to 0.140 ± 0.089 mv·s, P < 0.0001). Differences between the MRS2179 group (1.88 ± 1.45) and either the MRS2365 group (3.96 ± 0.19) or the combined treatment (MRS2179 and MRS2365) group (3.28 ± 0.11) were significant (P < 0.01).CONCLUSIONP2Y1R plays a regulatory role in visceral hypersensitivity in rats with experimental IBS. Specific antagonists of P2Y1R may have potential therapeutic value in treating abdominal pain in IBS.

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“…However, several findings detailed in the available literature from different countries such as the United States of America and Brazil do include similar observations of females being more afflicted with headache disorders than males. 8,9 Depression diagnoses based on patient health questionnaire PHQ-9 occurred more in the middle age group of FGID patients at a statistically significant level among the whole domain of Somatic syndrome and FGID ... Khayyat IBS subtypes. This relationship between age, depression, and IBS illuminates a compound problem which requires more global assessment and directed management of both conditions from the medical provider in a more multidisciplinary clinic setting.…”

Section: Brief Communicationmentioning

confidence: 99%

Functional somatic illnesses in patients with functional bowel disorders

Khayyat

2020

SMJ

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Objectives: To study the prevalence of functional gastrointestinal disorders (FGID) in Saudi patients with irritable bowel syndrome (IBS). Methods: A cross-sectional study was conducted in patients with IBS treated at a private tertiary medical center in western Saudi Arabia between 2013 and 2017. We used ROME 3 criteria with data from the Generalized Anxiety Disorder 7-item (GAD-7) scale, the Patient Health Questionnaire-9 (PHQ-9) depression scale, and International Classification of Headache Disorders (ICHD) to assess the prevalence of psychosomatic illness. Statistical analysis of frequency and statistical correlation was performed using Chi-square. Results: The final analysis of 307 patients revealed a combined 425 diagnoses of psychosomatic illness, including diagnoses of headache in 104 patients (34%), migraine in 93 patients (30.5%), fibromyalgia in 169 patients (55%), and depression in 59 patients (19%). There was a statistically significant correlation between patients' ages and diagnoses of joint pain and migraines. Conclusion: Fibromyalgia and headache disorders were common in this cohort of Saudi patients with IBS. This coexistence of illness is partly explained by the functional nature of these illnesses. Collective efforts to provide multidisciplinary care is needed for these patients.

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THE PREVALENCE AND CLINICAL CHARACTERISTICS OF PRIMARY HEADACHE IN IRRITABLE BOWEL SYNDROME: a subgroup of the functional somatic syndromes

Cited by 6 publications

References 38 publications

Is there an Association between Migraine and Gastrointestinal Disorders?

Is there an Association between Migraine and Gastrointestinal Disorders?

P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome

Functional somatic illnesses in patients with functional bowel disorders

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