Prevalence of celiac disease in siblings of Iranian patients with celiac disease

Abstract

-Context -Celiac disease, one of the best-known autoimmune human leukocyte antigen-dependent disorders, has a relatively increased prevalence in first-degree relatives. Objective -To determine the prevalence of celiac disease in siblings of patients with confirmed celiac disease. Methods -Siblings of confirmed celiac disease patients in our center were identified and enrolled in this study. Their serum immunoglobulin A and tissue transglutaminase antibody-enzyme-linked immunosorbent assay (anti-tissue transglutaminase, immunoglobulin A, and immunoglobulin G) were measured and multiple endoscopic duodenal biopsy specimens were obtained with parental consensus. Celiac disease was confirmed by observation of characteristic histological changes. Results -A total of 49 children (male, 29; female, 20; age, 2-16 years) with confirmed celiac disease in a pediatric gastroenterology ward were studied from 1999 to 2006. We found 30 siblings (female, 16) all shared in both parents. The only measurement available was for immunoglobulin A tissue transglutaminase antibody. A duodenal biopsy was performed in all 30 siblings. Clinical findings such as abdominal pain, fatigue, growth retardation and diarrhea were found in 53.3% of the completely studied siblings, and positive serology without histological changes was identified in four cases. Both serology and biopsy (confirmed new cases) were positive in 2 of the 30 siblings. Conclusion -High prevalence of celiac disease among siblings of patients with confirmed celiac disease necessitates serologic screening (and confirmatory biopsy if indicated) in families having celiac disease. It is advantageous to diagnose the disease as soon as possible because early diagnosis and diet intervention may prevent serious complications such as growth retardation, short stature, chronic diarrhea, and malignancy.

Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis

“…Forty-eight studies were included in this part of analysis as they reported serological prevalence among FDRs with one index case of CD ( 9,(11)(12)(13)(14)(30)(31)(32)(33)(34)(35)(36)39,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(52)(53)(54)(55)(56)(57)(58)(59)(60)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78). Overall, of 14,225 FDRs screened using AEA and/or anti-tTG Ab, 1,016 FDRs were seropositive ( 9,(11)…”

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

“…Celiac disease (CD) is an immune-mediated enteropathy that is caused by a permanent sensitivity to gluten by taking nutrients like wheat, barley, and also rye in genetically sensitive people (13,28,47) . CD was historically believed an intestinal disorders of childhood and adult life, characterised by failure to thrive, malabsorption, diarrhea, weight loss, vomiting, unusual stools, and also abdominal distention (12,38) .…”

Celiac Disease Overview in Children by Focused on Iranian Studies

“…Depending on the age and pubertal status, most children will experience a catch up phase where their growth potential may be realized. However, older children who have passed puberty are unlikely to grow if their growth phase has ended [11][12][13][14][15][16][17][18][19].…”

“…Biopsy confirmation is crucial, given the lifelong nature of the disease and the attendant need for an expensive and socially inconvenient diet. Although no studies have examined the number of biopsies required for diagnosis, we believe that at least four to six endoscopic-biopsy specimens should be obtained from the duodenum, given the patchy nature of the disease and the difficulty of orienting the small pieces of tissue taken during biopsy for assessment of villous morphology [13][14][15][16][17][18][19][20][21][22]. Causes of villous atrophy other than celiac disease are shown in Table 2 [23,24,25].…”

“…The result of this study presence the high prevalence of celiac disease among siblings of patients with confirmed celiac disease and suggest that serologic screening in families having celiac disease is necessary. It is advantageous to diagnose the disease as soon as possible because early diagnosis and diet intervention may prevent serious complications such as growth retardation, short stature, chronic diarrhea, and malignancy [18].…”