Treatment of inflammatory bowel disease and pregnancy: a review of the literature

Abstract

-Context -The inflammatory bowel disease is diagnosed frequently among woman of childbearing capacity. The management must be carefully because there are potential risks for the mother and fetus. Results and conclusions -We review literature about the management of inflammatory bowel disease in pregnancy. Some studies are needed to ensure the best approach to inflammatory bowel disease in pregnant women. HEADINGS -Inflammatory bowel disease. Pregnancy complications, infectious. Infliximab.

Crohn's disease and pregnancy

“…У женщин с активной формой заболевания или с вовлечением в патологический процесс подвздошной кишки, или после хирургической резекции кишечника, новорожденные имеют более низкую массу тела при рождении [5,6]. У беременных с БК установлена в два раза более высокая частота преждевременных родов по сравнению со здоровыми беременными [7]. При активной форме заболевания установлена более высокая частота мертворождения, по данным некоторых исследователей [8], эта частота достигает 35%.…”

Editorial Current opinion on treatment of inflammatory bowel disease in pregnant women

“…There is no evidence of teratogenicity of corticosteroids and they are prescribed for different forms of the disease [16]. Although there are differences between corticosteroids there is no report of maternal adrenal suppression, glucose intolerance, ocular side effects, hypertension, or congenital abnormalities with budesonide [17], which is commonly used in IBD, whereas an increase in the risk of oral cleft was found with prednisone in a meta-analysis [18].…”

“…Although there are differences between corticosteroids there is no report of maternal adrenal suppression, glucose intolerance, ocular side effects, hypertension, or congenital abnormalities with budesonide [17], which is commonly used in IBD, whereas an increase in the risk of oral cleft was found with prednisone in a meta-analysis [18]. Of course, the route of drug administration may affect drug plasma levels as well as its placental transfer [16]. Budesonide is mainly used as a rectal enema while prednisolone is used orally.…”

Enfermedad inflamatoria intestinal y embarazo: experiencia de 16 años

“…Se han comunicado casos aislados de retardo del crecimiento intrauterino, prematuridad e inmunodepresión fetal en pacientes tratadas con azatioprina y 6-mercaptopurina, considerados como fármacos clase D por la FDA. La ciclosporina, clasifi cada como clase C, se ha asociado a casos de retardo del crecimiento intrauterino y prematuridad 11 . Con respecto al uso de agentes biológicos anti TNF alfa, la mayoría de los estudios a la fecha, realizados con infl iximab y adalimumab, muestran resultados perinatales similares a la población general 12,13 .…”