Achados colonoscópicos em pessoas sem quadro clínico de doença colorretal

Petroianu, Andy; Alberti, Luiz Ronaldo; Lima, David Correa Alves De; Hauter, Heather Lynn; Rodrigues, Kelly Cristine de Lacerda; Mendes, Julia Cristina de Almeida

doi:10.1590/s0004-28032009000300006

Cited by 7 publications

(8 citation statements)

References 24 publications

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“…They were primarily located in the ascending colon, transverse colon, and rectum; in the latter, a higher incidence of multiple polyps was observed. 15 This data was very similar to the present findings, where polyps were more commonly observed in the rectum, sigmoid colon, and transverse colon.…”

Section: Discussionsupporting

confidence: 93%

“…In the study by Petroianu, pre-malignant lesions were observed in one-quarter of the patients, demonstrating that the removal of these lesions endoscopically prevents cancer and all its consequences, which can sometimes be fatal, 15 and thus reinforcing the importance of polypectomy, a procedure performed in 70 of the patients in the present study.…”

Section: Discussionsupporting

confidence: 71%

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Colonoscopic findings in patients younger than 40 years

Moreira

Santos

Amorim

et al. 2019

Journal of Coloproctology

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Objective To analyze the main endoscopic findings in patients under 40 years of age and the main indications for colonoscopy in these patients. Methods A retrospective study with 362 reports of patients under 40 years of age who underwent colonoscopy from January 2014 to June 2017 at the colonoscopy service of the General Hospital Roberto Santos. Colon preparation was performed with mannitol and the patients underwent sedation as the anesthetist criteria. Results Of the 362 patients analyzed, 192 (53%) were female. The mean age was 25 years (25.58 ± 11.95). The most frequent indications were inflammatory bowel disease in 24.3% (88) of the patients, bleeding in the lower digestive tract in 24% (87), and chronic diarrhea in 20.2% (73). The main colonoscopic findings were polyposis in 21.3% (77) of the patients and inflammatory alterations in 20.7% (75). Conclusion With the analysis of the data provided by the colonoscopies, it was possible to conclude that, when the investigation is adequate and the examination is well indicated, even under the age of 40, colonoscopy can help in the diagnostic and treatment of several pathologies, including those that may increase the risk of colorectal cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 71%

Colonoscopic findings in patients younger than 40 years

Moreira

Santos

Amorim

et al. 2019

Journal of Coloproctology

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“…A high cell-proliferation index suggests a more aggressive behavior on part of the neoplasm and may have important prognostic implications (22) . The average age of the study population was 63 years and the sex distribution was fairly equal, matching findings in the literature showing the prevalence of polyps in patients aged >50 years, with no sex preference (9,11,18,32) . The data also support the claim that patients with adenomas and colorectal cancer have a similar age distribution (generally >50 years) (1,11,21) .…”

Section: Discussionsupporting

confidence: 84%

Immunohistochemical evaluation of p53 and Ki-67 proteins in colorectal adenomas

Sousa

Rodrigues

Júnior

et al. 2012

Arq. Gastroenterol.

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-Context -The appearance of adenomas and their progression to adenocarcinomas is the result of an accumulation of genetic changes in cells of the intestinal mucosa inherited or acquired during life. Several proteins have been studied in relation to the development and progression of colorectal cancer, including tumor protein p53 (p53) and antigen identified by monoclonal antibody . Objective -To evaluate the expression of p53 and Ki-67 in colorectal adenomas and correlate the observed levels with clinical and pathologic findings. Method -The sample consisted of 50 adenomatous polyps from patients undergoing colonoscopy. After performing polypectomy, polyps were preserved in a formalin solution with 10% (vol./vol.) phosphate buffer, submitted for routine preparation of sections and slides and stained with hematoxylin and eosin. For each adenoma we then performed immunohistochemistry to detect specific p53 and Ki-67 proteins using a streptavidin-biotin-peroxidase enzyme immunoassay.Results -p53 was detected in 18% of the adenomas. The average Ki-67 protein index (i.Ki-67) was 0.49. A statistically significant difference was observed in p53 (P = 0.0003) and Ki-67 (P = 0.02) expression between adenomas with low-and high-grade dysplasia, particularly for p53. The expression of Ki-67 was greater in rectal adenomas than in colic adenomas (P = 0.02). No relationship was found between the expression of the two proteins in the sample. Conclusion -The p53 protein is expressed in a proportion of adenomas, while the Ki-67 protein was expressed in all adenomas. The expression of p53 was higher in adenomas with high-grade dysplasia. The expression of Ki-67 was higher in rectal adenomas and in adenomas with high-grade dysplasia. HEADINGS -Colorectal neoplasm. Tumor suppressor protein p53. Ki67-antigen. Immunohistochemistry.

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“…There was a higher incidence of adenoma and dysplasia in patients over the age of 50, but the difference did not reach statistical significance. Other studies have reported a higher incidence of adenomas in general and advanced adenomas in particular after the fifth decade of life 23 , 18 . There were no significant between-group differences in presence of villous component.…”

Section: Discussionmentioning

confidence: 85%

Influence of patient age and colorectal polyp size on histopathology findings

Silva

Rosa

Santos

et al. 2014

ABCD, arq. bras. cir. dig.

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BackgroundColorectal cancer is a major cause of morbidity and mortality and can arise through the adenoma-carcinoma sequence. Colonoscopy is considered the method of choice for population-wide cancer screening.AimTo assess the characteristics of endoscopically resected polyps in a consecutive series of patients who underwent colonoscopy at a university hospital and compare histopathology findings according to patient age and polyp size.MethodsRetrospective, cross-sectional of 1950 colonoscopy reports from consecutively examined patients. The sample was restricted to reports that mentioned colorectal polyps. A chart review was carried out for collection of demographic data and histopathology results. Data were compared for polyps sized ≤0.5 cm and ≥0.6 cm and then for polyps sized ≤1.0 cm and ≥1.1 cm. Finally, all polyps resected from patients aged 49 years or younger were compared with those resected from patients aged 50 years or older.ResultsA total of 272 colorectal polyps were resected in 224 of the 1950 colonoscopies included in the sample (11.5%). Polyps >1 cm tended to be pedunculated (p=0.000) and were more likely to exhibit an adenomatous component (p=0.001), a villous component (p=0.000), and dysplasia (p=0.003). These findings held true when the size cutoff was set at 0.5 cm. Patients aged 50 years or older were more likely to have sessile polyps (p=0.023) and polyps located in the proximal colon (p=0.009). There were no significant differences between groups in histopathology or presence of dysplasia.ConclusionPolyp size is associated with presence of adenomas, a villous component, and dysplasia, whereas patient age is more frequently associated with sessile polyps in the proximal colon.

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Achados colonoscópicos em pessoas sem quadro clínico de doença colorretal

Cited by 7 publications

References 24 publications

Colonoscopic findings in patients younger than 40 years

Colonoscopic findings in patients younger than 40 years

Immunohistochemical evaluation of p53 and Ki-67 proteins in colorectal adenomas

Influence of patient age and colorectal polyp size on histopathology findings

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