Prevalence of Barrett's esophagus in individuals without typical symptoms of gastroesophageal reflux disease

Freitas, Mauro Carneiro de; Moretzsohn, Luciana Dias; Coelho, Luiz Gonzaga Vaz

doi:10.1590/s0004-28032008000100009

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…This observation can be explained by those genetic theories that predispose to this suffering and that do not necessarily require long exposure to environmental factors, not yet well involved. [9][10][11] As to nutritional status, what was observed is in keeping with what was stated by Thrift et al 12 in a study in which they used bioimpedance. They showed that the increase in body fat or the BMI did not raise the risk for BE, but was related with central adiposity.…”

Section: Discussionsupporting

confidence: 82%

“…13 The data about the presence and duration of symptoms provided by the scientific literature reviewed are currently a subject under discussion and give rise to contrasting opinions. 10,14 The prevalence of typical symptoms, indifferent regarding the grade of the lesion, allow us to doubt the interpretation of former studies which suggest that there is less esophageal sensitivity in BE patients, due to modifications caused by the alterations of the new modified and damaged mucosa. 10 Anandasabapathy 7 and Sierra 15 have found a great number of falsenegatives and false-positives in their studies.…”

Section: Discussionmentioning

confidence: 99%

“…10,14 The prevalence of typical symptoms, indifferent regarding the grade of the lesion, allow us to doubt the interpretation of former studies which suggest that there is less esophageal sensitivity in BE patients, due to modifications caused by the alterations of the new modified and damaged mucosa. 10 Anandasabapathy 7 and Sierra 15 have found a great number of falsenegatives and false-positives in their studies. It is our criterion that the existence of modified mucosa areas, mostly small surfaces, do not achieve to diminish esophageal sensitivity, globally.…”

Section: Discussionmentioning

confidence: 99%

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Clinical picture of patients with Barrett’s esophagus and different grades of dysplasia

Escobar¹,

Velázquez²

2018

GHOA

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Introduction: Barrett's esophagus (BE) is the most relevant premalignant condition for the development of carcinoma of the esophagus, and the presence of dysplasia represents a progression marker. Objectives: To identify the different clinical manifestations in a group of patients with BE and different grades of dysplasia. Methods: An observational, descriptive and transversal study was carried out which included 86 patients with a diagnosis of BE seen at the Endoscopy Department from the National Center for Minimally Invasive Surgery between January 2012 and January 2014. Clinical-epidemiological variables were compared according to the presence or not of dysplasia and its grade.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical picture of patients with Barrett’s esophagus and different grades of dysplasia

Escobar¹,

Velázquez²

2018

GHOA

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“…Fonseca et al (11) found a concomitant presence of alcoholism and smoking in 86.96% of esophagus cancer patients. Tobacco associated to the consumption of alcoholic beverages significantly increases the development of esophagus cancer (12,13) . Dysphagia was the most frequent symptom similar to other works in literature (10,26) .…”

Section: Discussionmentioning

confidence: 99%

Grade of esophageal cancer and nutritional status impact on postsurgery outcomes

Marin

Lamônica-Garcia

Henry

et al. 2010

Arq. Gastroenterol.

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-Context -Undernutrition is a well known underlying cause in both disease onset and outcome. Objective -To associate disease severity with pre surgical nutritional status, the main postsurgical complications, and mortality in esophagus cancer patients. Method -Retrospective data from 100 patients (38-81 years old, 85% males) who had undergone esophagectomy (G1/n = 25) or gastro/jejunostomy (G2/n = 75) between 1995 and 2004. Data included clinical, endoscopic, histological (TNM-UICC), dietary, anthropometric, blood chemistry, and postsurgical (>30 days) complications and mortality. Surgical groups were compared by Student's test and existing associations between variables by either c 2 or Fisher exact tests with P = 0.05. Results -The studied sample was predominantly male (85%), white (80%), smokers and alcoholics (95%), dysphagics (95%) mostly presenting body weight loss before cancer diagnosis (78%). TNM III and IV predominated over I and II, associated (P≤0.005) with higher body mass index and hypoalbuminemia (<3.5 mg/dL) frequency. Esophagic obstructions (n = 77) were associated (P = 0.002) with lower body mass index (kg/m 2 ). Postsurgical complications were more common in G1 (69.2%) than G2, predominantly with infections in G2 (80%) and pleura-pulmonary in G1 (61%). Body mass index and lower lymphocyte counts were associated with early infections and postsurgical complications in G2. Plasma albumin levels were lower in this group than G1, and were associated with postsurgical complications and mortality whereas lower lymphocyte counts was associated with mortality in G1. Conclusions -Disease severity (or late diagnosis) is associated with poor nutritional status and palliative surgery which lead to more complicated postsurgery outcome and mortality. Early diagnosis and nutritional intervention are the recommended actions.

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“…Moreover, in a study on patients having only dyspepsia in Brazil, the rate of ERD was found to be as low as 8.6% (47). The study reporting the lowest rate of histopathological BE diagnosis was conducted in Spain (0.08%) (48).…”

Section: The Epidemiology Of Gerd Complications In Turkey and Around mentioning

confidence: 97%

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

Bor

Yüksel

2017

Turk J Gastroenterol

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Although many studies are conducted on gastroesophageal reflux disease (GERD) and its complications, the questionnaires and reflux definitions used in the studies are different. Mayo, GERD-Q, DIGEST-Q, RDQ, and various other questionnaires that were created and have been used in the studies. The GERD definition that is mostly accepted around the world is the presence of the complaints of heartburn and/or regurgitation at least once a week. However, many different definitions, such as the presence of heartburn and/or regurgitation at least twice a week or at least once a year (if once a week, "frequent"; if once a year, "rare") and the presence of heartburn and/or regurgitation without considering the frequency and severity, were all used in the studies. Therefore, it is quite difficult to obtain a single datum by collecting these studies. However, studies including all questionnaires and reflux definitions were considered while collecting this data.Another problem encountered while performing epidemiological scanning of GERD is that when the world was separated into two parts as the East and the West, some countries that were different from each other were included in the same group (such as Iran-China and Germany-Brazil). Even though continents are considered for this separation, countries that do not resemble each other from any perspective, such as Iran and China, were included in the same group. Therefore, groups must be formed according to the higher number of ethnic distributions. There are also regional epidemiological differences even in the same country. Moreover, there is no term equivalent to heartburn and regurgitation in some Eastern languages.Turkey is geographically located in the middle of the Eastern and Western countries and the epidemiology of GERD and its complications is similar to both geographical groups (Figure 1). In the Eastern countries, the prevalence of GERD is lower and regurgitation is predominant. On the other hand, in the Western countries, the prevalence of GERD is higher and heartburn is predominant. Considering the complications, erosive esophagitis, Barrett's esophagus, and associated esophageal adenocarcinoma are seen in the Western countries more commonly.In GERD epidemiological studies performed in Turkey, the Mayo questionnaire was mostly used (1, 2). The GERD-Q form was used in one study (3). The studies in which the Mayo questionnaire was used, found the prevalence of GERD as 20% (1), 19.3% (2), 12.5% (4), and 22.8% (5,6), respectively. In the study using the other question form, the prevalence of GERD was 24.7% (3). When 5 studies were evaluated cumulatively, the prevalence was calculated to be 23%. It was observed that regurgitation was predominant in all of the studies. In the cumulative evaluation, the rate of prevalence was 23% for regurgitation and 19% for heartburn.While the date of the publications on the epidemiology of GERD goes back to the 2000s in the countries to the east of Turkey, the first articles on this subject were written in 1990s in the Western cou...

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Prevalence of Barrett's esophagus in individuals without typical symptoms of gastroesophageal reflux disease

Cited by 11 publications

References 30 publications

Clinical picture of patients with Barrett’s esophagus and different grades of dysplasia

Clinical picture of patients with Barrett’s esophagus and different grades of dysplasia

Grade of esophageal cancer and nutritional status impact on postsurgery outcomes

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

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