Vertical transmission of hepatitis C virus in a hospital in southern Brazil

Peixoto, Mario F.; Mattos, Ângelo Alves de; Remião, José Oscar dos Reis; Alexandre, Cláudio Osmar Pereira; Lemos, Sibele Krebs de; Azevedo, Ana Maria Ponzio de

doi:10.1590/s0004-28032004000200003

Cited by 6 publications

(9 citation statements)

References 31 publications

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“…Only a few studies of HCV MTCT among HCV/HIV-coinfected populations have been conducted in Brazil [31,32] and Argentina [33][34][35]. In our study, HCV MTCT occurred only among mothers who were HCV-RNA positive (viremic).…”

Section: Discussionmentioning

confidence: 53%

“…Because most studies base transmission rates on cases with anti-HCV persistence after 18 months of age, there is also a chance that we captured additional cases of infants with transient infection who cleared the HCV virus and did not mount a persistent anti-HCV response [46]. The presence of transient viremia should be regarded as a consequence of spontaneous viral clearance after MTCT [31,36,46]. Most studies have not been able to establish a clear association between HCV genotype and MTCT [26,47,48].…”

Section: Discussionmentioning

confidence: 99%

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Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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Background. Maternal human immunodeficiency virus (HIV) coinfection has been associated with increased hepatitis C virus (HCV) mother-to-child transmission (MTCT). We hypothesized that HCV/HIVcoinfected women with well-controlled HIV disease would not have increased HCV MTCT. Methods. The NISDI Perinatal and LILAC cohorts enrolled HIV-infected pregnant women and their infants in Latin America and the Caribbean. This substudy evaluated the HCV infection status of mothers at participating sites and their live born, singleton infants who had a 6-month postnatal visit by December 31, 2008. Mothers who were anti-HCV-positive, or who had CD4 counts (cells/mm 3 ) <200 with detectable HCV RNA, were considered HCV-infected. All HCV-infected women were tested for HCV RNA. Infants with HCV RNA were considered HCV-infected. Results. Of 1042 enrolled women, 739 (71%) mother-infant pairs met the inclusion criteria. Of the 739 women, 67 (9%) were anti-HCV-positive and 672 anti-HCV-negative [68 (10%) with CD4 counts <200; of these, 3 (4.4%) were HCV RNA-positive]. Therefore, our study population comprised 70 HCV-infected (47 with HCV RNA) and 669 HCV-uninfected women (and their infants). Factors associated with maternal HCV infection included unemployment (odds ratio [OR] = 2.58

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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“…The samples of seven studies comprised only women. 35 , 36 , 37 , 38 , 39 , 40 , 41 The mean age was 26.7 years among the papers that presented this information. 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 25 , 26 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 40 , 41 , 42 , 43 Eight of the selected papers had no data regarding gender and age of the participants.…”

Section: Resultsmentioning

confidence: 90%

“…9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 25 , 26 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 40 , 41 , 42 , 43 Eight of the selected papers had no data regarding gender and age of the participants. 38 , 39 , 44 , 45 , 46 , 47 , 48 , 49 …”

Section: Resultsmentioning

confidence: 99%

Prevalence of human immunodeficiency virus/hepatitis C virus co-infection in Brazil and associated factors: a review

Kuehlkamp¹,

Schuelter-Trevisol²

2013

The Brazilian Journal of Infectious Diseases

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The hepatitis C virus and human immunodeficiency virus share the same transmission routes, which makes co-infection an unfavorable condition for the natural history of both viral diseases. In this context, it should be highlighted that the knowledge of the extent of co-infection and associated risk factors is a vital tool for prevention and control over infectious diseases. The aim of this study was to review the literature, seeking to examine the prevalence of human immunodeficiency virus/hepatitis C virus co-infection reported in studies conducted in Brazil, and identify the main risk factors associated with co-infection. The electronic search was conducted in the Medline, Lilacs and SciELO databases. The following keywords were used: human immunodeficiency virus and Hepatitis C or hepatitis C virus and Brazil. The search led to 376 articles, of which 69 were selected for data extraction. We excluded animal studies, reports or case series, review articles, letters to the editor, other types of hepatitis and those studies in which co-infected patients were intentionally selected for comparison to single infected individuals. As a result, 40 articles were reviewed. The majority of the population in these studies was male (71%) and young adults, with a mean age of 26.7 years. The prevalence of hepatitis C virus co-infection among individuals living with human immunodeficiency virus in the studies conducted in Brazil ranged from 3.3% (serum samples) to 82.4% (drug users), with an average of 20.3%. The findings reveal that the prevalence of human immunodeficiency virus/hepatitis C virus co-infection is highly variable, depending on the characteristics of the study population. Risk factors associated with human immunodeficiency virus/hepatitis C virus co-infection were injection drug use and blood transfusion.

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“…Estudo realizado na região sul do Brasil com 1.090 mulheres grávidas revelou prevalência de transmissão vertical de 5,56% entre mães portadoras do VHC (12) . A taxa de transmissão vertical deste vírus pode variar de 4% a 7% por gestação e ocorre apenas quando o HCV RNA é detectável no soro materno na ocasião do parto (2) .…”

Section: Discussionunclassified

Comparação do perfil epidemiológico das hepatites B e C em um serviço público de São Paulo

Cruz

Shirassu²,

Martins

2009

Arq. Gastroenterol.

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RESUMO -Contexto -As hepatites virais constituem doença de notificação compulsória e apresentam grande importância em nosso meio devido à elevada prevalência. A grande importância das hepatites virais em saúde pública vem da sua grande prevalência e incidência e pela possibilidade de complicações das formas agudas e crônicas (4) . Bases de dados obtidos de bancos de sangue na América Latina revelaram que os portadores de VHB excedem os 6 milhões, estando o Brasil e outros países da América do Sul (como Colômbia, Venezuela e Peru) dentre aqueles que apresentam territórios de alta endemicidade (16) . Estudos mostraram que a frequência da infecção pelo vírus da hepatite B (VHB) no Brasil varia de 0,5% a 1,1% no sul do país até 1,5% a 3,0% na região centro e noroeste, podendo alcançar até 15% na região amazônica, considerada de alta endemicidade (16) . A prevalência de VHB em nosso país aumenta da região sul em direção ao noroeste, com taxas de anti-HBc que variam de 61,5% no Acre, 10,2% em São Paulo e 5,5% no Rio de Janeiro e Santa Catarina (8) . O Ministério da Saúde estima que, no Brasil, pelo menos 15% da população já entrou em contato com VHB e que 1% da população apresenta formas crônicas (4) . Não se sabe precisamente a prevalência nacional do vírus da hepatite C (VHC), porém, há relatos que sugerem que essa taxa varie de 1% a 2% da população em geral (7) . Estudo realizado na região sudeste mostrou prevalência de 1,42% de portadores de anti-VHC na cidade de São Paulo. Dados provenientes do Centro de Vigilância Epidemiológica (CVE) revelam a confirmação de 3.649Trabalho realizado no Núcleo

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Vertical transmission of hepatitis C virus in a hospital in southern Brazil

Abstract: These results suggest that the prevalence of hepatitis C virus infection in pregnant women should not be neglected, and early diagnosis of vertical transmission and the follow up of infected children should be emphasized.

Cited by 6 publications

References 31 publications

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Prevalence of human immunodeficiency virus/hepatitis C virus co-infection in Brazil and associated factors: a review

Comparação do perfil epidemiológico das hepatites B e C em um serviço público de São Paulo

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