Growth assessment in children with extra-hepatic portal vein obstruction and portal hypertension

Bellomo-Brandão, Maria Ângela; Morcillo, André Moreno; Hessel, Gabriel; Cardoso, Sílvia Helena; Servidoni, Maria de Fátima; Da-Costa-Pinto, Elizete Aparecida Lomazi

doi:10.1590/s0004-28032003000400009

Cited by 16 publications

(9 citation statements)

References 14 publications

(22 reference statements)

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“…Umbilical sepsis is the most frequently implicated factor; in various studies, the history of sepsis is available in 0-56% of children with EHPVO [7]. We found that of 232 patients seen over 5 years, 47 had been delivered at home and 12 had history of umbilical sepsis [10].…”

Section: Discussionmentioning

confidence: 78%

Relation of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels to growth retardation in extrahepatic portal vein obstruction

et al. 2008

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Section: Discussionmentioning

confidence: 78%

Relation of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels to growth retardation in extrahepatic portal vein obstruction

et al. 2008

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“…75 Another study however did not show any growth impairment in children with PVT. 76 Chronic PVT in adults presents with recurrent upper gastrointestinal bleed like children. Bleed may occur from esophago-gastric varices or ectopic varices in duodenum or elsewhere.…”

Section: Chronic Portal Vein Thrombosis (Extra Hepatic Portal Venous mentioning

confidence: 99%

Portal Vein Thrombosis

Chawla

Bodh

2015

Journal of Clinical and Experimental Hepatology

142

130

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Portal vein thrombosis is an important cause of portal hypertension. PVT occurs in association with cirrhosis or as a result of malignant invasion by hepatocellular carcinoma or even in the absence of associated liver disease. With the current research into its genesis, majority now have an underlying prothrombotic state detectable. Endothelial activation and stagnant portal blood flow also contribute to formation of the thrombus. Acute non-cirrhotic PVT, chronic PVT (EHPVO), and portal vein thrombosis in cirrhosis are the three main variants of portal vein thrombosis with varying etiological factors and variability in presentation and management. Procoagulant state should be actively investigated. Anticoagulation is the mainstay of therapy for acute non-cirrhotic PVT, with supporting evidence for its use in cirrhotic population as well. Chronic PVT (EHPVO) on the other hand requires the management of portal hypertension as such and with role for anticoagulation in the setting of underlying prothrombotic state, however data is awaited in those with no underlying prothrombotic states. TIPS and liver transplant may be feasible even in the setting of PVT however proper selection of candidates and type of surgery is warranted. Thrombolysis and thrombectomy have some role. TARE is a new modality for management of HCC with portal vein invasion. ( J CLIN EXP HEPATOL 2015;5:22-40)

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“…83 An early report of marked growth retardation in children with extrahepatic portal vein obstruction 86 has not been confirmed in subsequent studies. 87 Obstructive jaundice is an uncommon complication. 88,89 It was detected in 8 of 121 children presenting over a 14-year period with cavernous transformation and regressed after surgical decompression.…”

Section: Hepatic Arterymentioning

confidence: 99%

Developmental abnormalities and liver disease in childhood

Portmann¹,

Roberts²

2012

MacSween's Pathology of the Liver

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Growth assessment in children with extra-hepatic portal vein obstruction and portal hypertension

Abstract: Portal hypertension due to extra-hepatic portal vein obstruction was not associated with growth impairment in the group of children studied.

Cited by 16 publications

References 14 publications

Relation of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels to growth retardation in extrahepatic portal vein obstruction

Relation of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels to growth retardation in extrahepatic portal vein obstruction

Portal Vein Thrombosis

Developmental abnormalities and liver disease in childhood

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