Esofagite ulcerativa associada ao uso de alendronato de sódio: achados histopatológicos e endoscópicos

Fernandes, Paula Ávila; Pires, Marcelo Soares; Gouvêa, Agostinho Pinto

doi:10.1590/s0004-28032002000300007

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…Endoscopic findings include isolated or combinations of erosions, ulcers (various size and shapes), ulcers with bleed, pill fragments, and medication coatings. 13 Classical kissing ulcers are defined as ulcers which are facing each other and are described to be associated with PE but are not pathognomonic. The incidence of kissing ulcers and esophageal erosions were 30 and 26.6%, respectively, in this study.…”

Section: Discussionmentioning

confidence: 99%

Pill Esophagitis: Clinical and Endoscopic Profile

Pemmada,

Shetty,

Murali

et al. 2023

Journal of Digestive Endoscopy

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Background Medications can rarely cause esophageal injury and present with acute symptoms. Multiple factors, including the type of medication, comorbidity, and method of ingestion play a role in causing drug-induced or pill esophagitis (PE). We analyzed the clinical, endoscopic, and histopathological profiles of PE cases at our gastroenterology outpatient clinic. Methods Medical records of PE cases were reviewed retrospectively over a period of 5 years at a tertiary care hospital in India from May 2017 to May 2022. The data were collected and analyzed using descriptive statistical analysis. Results A total of 30 patients diagnosed with PE were involved in the study. A slight male preponderance of 56.7% was noted with a mean age of 40.7 years. Odynophagia was the dominant symptom (70%) with a mean duration of symptoms of 5.63 days. The most common location was at the mid-esophagus (80%) followed by the lower esophagus (10%). The majority (56.7%; 17/30) had over-the-counter (OTC) drug consumption, followed by doxycycline (33.3%; 10/30). Kissing ulcers were seen in 30% of the subjects; 90% of the patients received a combination of proton pump inhibitors and sucralfate suspension for 2 weeks along with discontinuation of the causative drug, with a 96.7% resolution rate. Conclusion OTC medication and antibiotics such as doxycycline are the leading cause of PE. Prompt recognition and discontinuation of the causative drug are crucial in preventing complications. Patient education is vital in preventing PE regarding the usage of OTC medicines in developing countries.

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Section: Discussionmentioning

confidence: 99%

Pill Esophagitis: Clinical and Endoscopic Profile

Pemmada,

Shetty,

Murali

et al. 2023

Journal of Digestive Endoscopy

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“…According to Margonato, Thomson and Paoliello (2008), only 23.5% of victims of unintentional drug poisoning received instructions on the correct use of medication at dispensation, as registered by a poison control center in Brazil. Lack of knowledge on medication may result in poor adherence, drug therapy failures, increased incidence of adverse effects, and aggravation of clinical conditions (Fernandes, Pires, Gouvêa, 2002;Margonato, Thomson, Paoliello, 2008;Oenning, Oliveira, Blatt, 2011). On the other hand, knowledge about medication is a key component of therapy success, as reported by Angelini et al (2009) in a study demonstrating that improvement of patients' knowledge on the management of inhaled corticosteroid during an education program was associated with patients' clinical progress.…”

Section: Discussionmentioning

confidence: 99%

Impact of a drug dispensing model at a Community Pharmacy in Goiânia, Goiás, Brazil

Ferreira

Prudente

Dewulf

et al. 2018

Braz. J. Pharm. Sci.

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Although dispensing of medication has been addressed by theoretical models, studies that confirm the impact of this service are still needed. The objective was to evaluate the impact of a new model of medicine dispensing system on patients' medication knowledge, adherence to treatment and satisfaction. One hundred and four patients attending the dispensing service of a community pharmacy between 21 January 2013 and 20 April 2013 were included in this intervention study. The impact of the service on patients' medication knowledge, adherence to treatment and satisfaction was assessed by using validated questionnaires at two time points: at the moment of medication dispensing and 30 days thereafter by telephone contact. Statistical analysis was performed by McNemar's test, and a p<0.05 was set as statistically significant. The number of patients showing insufficient knowledge about medications decreased by 50% (p < 0.05), and the number of those showing sufficient knowledge was three times greater (p < 0.05) after medicine dispensing. A high level of satisfaction was observed. Improvement of medication adherence, however, was not observed. The proposed system model for drug dispensing improved patients' knowledge about medication and satisfaction.

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“…The lack of patient knowledge of medications may result in poor adherence and a negative impact on the therapy success, due to pharmacotherapy failure, increased incidence of adverse effects and intoxications, and deterioration in health status (Fernandes, Pires, Gouvêa, 2002;Margonato, Thomson, Paoliello, 2008;Oenning;Oliveira;Blatt, 2011). This is also evident in previous studies, as reported by Margonato et al (2008), correlating the incidence of hospitalization secondary In the process description, we have found that most of the DRPs identified were related to the fact that the patient did not know how to use medication appropriately.…”

Section: Discussionmentioning

confidence: 99%

Medication dispensing as an opportunity for patient counseling and approach to drug-related problems

Ferreira

Prudente

Dewulf

et al. 2016

Braz. J. Pharm. Sci.

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The objective was to describe and evaluate a model of drug dispensing developed and implemented in a community pharmacy in Brazil. This was a descriptive, observational, quasi-experimental study performed in the period between 21 January 2013 and 20 April 2013. The model was evaluated and described in terms of three parameters: structure, process and outcome. The description and assessment of each parameter was performed as follows: (I) Structure: profile of patients, pharmacist's professional profile, physical facility, informational material; (II) Process: drug-related problems, pharmaceutical interventions performed, results of pharmaceutical interventions; (III) Outcome: patient knowledge of medications. Dispensing service improved patient knowledge of medications (p < 0.05), which was associated with pharmacotherapy complexity (p < 0.05). The main problems identified were related to lack of patient knowledge regarding their medication (52.9%). Pharmaceutical interventions were mostly performed directly to the patients (86.3%) by verbal (95.4%) and written (68.2%) information, and most of the problems were completely solved (62.7%). The medicine dispensing model was able to identify and solve drug-related problems and promote an improvement in patient knowledge about medication.Uniterms: Community Pharmacy. Medicines/dispensing. Patients/directive counseling. Medication/ errors. Pharmaceutical Care. Quasi-experimental study.O objetivo foi descrever e avaliar um modelo de serviço de dispensação de medicamentos desenvolvido e implantado em uma Farmácia Comunitária no Brasil. Trata-se de restudo descritivo, observacional e quase-experimental, realizado no período de 21 de janeiro a 20 de abril de 2013. A descrição e avaliação do modelo foi realizada segundo os parâmetros: estrutura, processo e resultado.Os aspectos descritos e avaliados foram: 1. Estrutura: perfil dos pacientes, perfil profissiográfico dos farmacêuticos, estrutura física, material de informação; 2. Processo: problemas relacionados ao medicamento detectados, intervenções farmacêuticas realizadas, resultados das intervenções farmacêuticas; 3. Resultado: conhecimento do pacientes sobre os medicamentos utilizados. A dispensação proporcionou melhora do conhecimento do paciente sobre os medicamentos (p < 0,05), que demonstrou-se associada à complexidade da farmacoterapia (p < 0,05). Foram identificados majoritariamente problemas relacionados à falta de condições do paciente em utilizar o medicamento (52,94%). As intervenções farmacêuticas foram realizadas predominantemente junto ao paciente (86,27%) através do fornecimento de informações verbais (95,4%) e escritas (68,2%) e, em sua maioria, o problema que originou a intervenção foi totalmente resolvido (62,75%).O serviço foi capaz de identificar e resolver os problemas relacionados ao medicamento e contribuiu para a melhoria do conhecimento dos pacientes relativo aos medicamentos utilizados.Unitermos: Farmácia Comunitária. Medicamentos/dispensação. Pacientes/aconselhamento diretivo. Medicação/erros. ...

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Esofagite ulcerativa associada ao uso de alendronato de sódio: achados histopatológicos e endoscópicos

Cited by 10 publications

References 16 publications

Pill Esophagitis: Clinical and Endoscopic Profile

Pill Esophagitis: Clinical and Endoscopic Profile

Impact of a drug dispensing model at a Community Pharmacy in Goiânia, Goiás, Brazil

Medication dispensing as an opportunity for patient counseling and approach to drug-related problems

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