Elevação da gama-glutamiltransferase sérica na hepatopatia esquistossomótica não se correlaciona com a carga parasitária e precede alterações ultra-sonográficas

Feldner, Ana Cristina de Castro Amaral; Aguiar, Luciano F.; Souza, Mônica Rodrigues de Araújo; Toledo, Carlos Fischer de; Borges, Durval Rosa

doi:10.1590/s0004-28032002000100006

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…5, in group of subjects with the disease, an increase in the level of AST, in relation to control group. Although an increase of ALT was not observed in this work, previous studies suggest that high parasite load is one of the mechanisms for elevation of ALT in schistosomiasis (Amaral et al 2002).…”

Section: Discussioncontrasting

confidence: 78%

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Cunha

Silva

Bessa

et al. 2012

Acta Parasitologica

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Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden on carriers of schistosomiasis (n = 30) in the acute phase in comparison to healthy subjects (n = 30). The pro-oxidant parameter used was the colorimetric quantification of reactive substances to thiobarbituric acid, while the antioxidant markers used were blood content of reduced glutathione and determination of the activity of catalase. The worm burden was assessed by Kato-Katz method. The results pointed out that initially there was no difference in the catalase activity. However, there was a positive correlation between the increase in parasitic load and intensity of lipid peroxidation, and decrease in the content of reduced glutathione. Additionally, only the aspartate aminotransferase levels presented to be high, while there was a decrease in bilirubin level. Therefore, a possible association between the establishment of the oxidative stress in tissue and the parasitic load of Schistosoma mansoni is suggested.

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Section: Discussioncontrasting

confidence: 78%

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Cunha

Silva

Bessa

et al. 2012

Acta Parasitologica

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“…Poderia ser questionado se a carga parasitária alteraria os níveis de GGT. No entanto, recentemente, AMARAL et al (2) demonstraram não haver correlação significativa entre a carga parasitária e os níveis séricos de GGT. A relação encontrada por esses autores entre GGT elevada e índice de protrombina elevado poderia sugerir que a GGT se alteraria em formas mais avançadas da doença e não como resultado de indução microssomal.…”

Section: Discussionunclassified

Hipertensão portal esquistossomótica: influência do fluxo sangüíneo portal nos níveis séricos das enzimas hepáticas

Alves

Fontes

Melo

et al. 2003

Arq. Gastroenterol.

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1. The portal blood flow was bigger in patients that the serum level of GGT was bigger; 2. the gamma-glutamil transferase is the variable of the hepatic screening evaluation more representative of the portal flow influence in hepatic functional activity in patients with hepatosplenic schistosomiasis, and 3. probably, the different surgeries through hemodynamics modifications, are beneficial in to diminish the degree of cholestasis or in decrease the microssomal induction.

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“…The most important event in schistosomiasis is the hepatic changes that occur in the definitive hosts (AMARAL et al, 2002), which are related to fibrosis (TAO et al, 2003). Other studies have shown that hepatic function only changes in more severe forms of the disease, with organomegalies and ascites, or in association with uncompensated hepatitis or cirrhosis (FAHIM et al, 2000;EL-SHAZLY et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Neto

Alves

et al. 2013

Rev. Bras. Parasitol. Vet.

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The South American water rat Nectomys squamipes is a wild mammal reservoir of Schistosoma mansoni in Brazil. In the present study, wild rodents were collected in the field and categorized into two groups: infected and uninfected by S. mansoni. Blood was collected to analyze changes in the serum glucose level (mg/dL) and liver fragments were used to determine the hepatic glycogen content (mg of glucose/g tissue). The histological examination showed inflammatory granulomatous lesions in different phases of development in the liver of rodents naturally infected with S. mansoni, in some cases with total or partial occlusion of the vascular lumen. Early lesions were characterized by the presence of inflammatory infiltrate around morphologically intact recently deposited eggs. Despite the significance of these histological lesions, the biochemical changes differed in extent. N. squamipes naturally infected by S. mansoni showed no variation in hepatic glycogen reserves. These findings were accompanied by a significant increase in plasma glucose contents, probably as a consequence of amino acids deamination, which are degraded, resulting in the formation of intermediates used as precursors for the glucose formation, without compromising the reserves of liver glycogen. In the wild, naturally infected N. squamipes can maintain S. mansoni infections without undergoing alterations in its carbohydrate metabolism, which minimizes the deleterious effects of S. mansoni.Keywords: Biochemical alterations, rodents, wild reservoirs, alternative model. ResumoNectomys squamipes é um mamífero silvestre reservatório de Schistosoma mansoni no Brasil. No presente estudo, os roedores silvestres, colhidos no campo, foram classificados em dois grupos: infectado e não infectado por S. mansoni. O sangue foi colhido para análise da alteração no nível de glicose sérico (mg/dL) e fragmentos de fígado foram usados para determinar o conteúdo de glicogênio hepático (mg de glicose/g tecido). A análise histológica demonstrou lesões granulomatosas em diferentes fases de desenvolvimento no tecido hepático dos roedores naturalmente infectados com S. mansoni, localizados principalmente na região periportal, com total ou parcial oclusão do lúmen vascular. As lesões foram caracterizadas por presença de infiltrado inflamatório ao redor de ovos morfologicamente intactos recentemente depositados. Apesar da grande significância das lesões histológicas, as alterações bioquímicas não diferiram no mesmo

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Elevação da gama-glutamiltransferase sérica na hepatopatia esquistossomótica não se correlaciona com a carga parasitária e precede alterações ultra-sonográficas

Cited by 9 publications

References 16 publications

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Hipertensão portal esquistossomótica: influência do fluxo sangüíneo portal nos níveis séricos das enzimas hepáticas

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

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