Causas da desnutrição pós-gastrectomia

Papini-Berto, Sílvia Justina; Burini, Roberto Carlos

doi:10.1590/s0004-28032001000400011

Cited by 23 publications

(18 citation statements)

References 12 publications

(34 reference statements)

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“…Iron-deficiency anemia is common after some gastrointestinal surgeries, such as gastric resections (gastrectomies), affecting approximately 60% of gastrectomized patients [ 5 , 6 ]. Iron deficiency in oncological patients combined with gastrointestinal complications compromise the efficacy of chemotherapy, promote general malnutrition, aggravate cancer cachexia, and may contribute to a worse prognosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

et al. 2018

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Polydextrose (PDX) ingestion may increase the intestinal absorption of iron. This study evaluated the effects of 7.5% polydextrose supplementation on markers of iron uptake, transport and storage in partially gastrectomized rats. Half of a batch of 40 male Wistar rats (250 g) underwent Billroth II partial gastrectomy with anterior truncal vagotomy (GXT), while the other half underwent sham gastrectomy (SHAM). At 7 postoperative days, the animals were subdivided into four groups (n = 10): Sham Control and GXT Control (no polydextrose); Sham PDX and GXT PDX (with 7.5% PDX). The animals were euthanized after 60 day of PDX treatment. Organ weight, cecal pH, the characterization and quantification of short-chain fatty acids (SCFA), hematological parameters, hepatic iron content and the expression of ferroportin (FPT) in the jejunum, cecum, colon and liver were evaluated. PDX caused changes in the cecum of the supplemented animals, where there was a decrease in pH, increase in cecal wall and marked production of SCFA, especially acetic and propionic acids (p < 0.05). Hepatic iron levels were lower in GXT animals. PDX increased hemoglobin (HGB) values by 29.2% and hematocrit (HCT) by 55.8% in the GXT PDX group compared to the GXT Control group. The GXT PDX group had lower hepatic FPT expression (p < 0.05). PDX led to increased SCFA concentration in the supplemented animals. Considering that SCFAs play a central role in the increasing nutrients uptake, this mechanism may be involved in altering the hematology profile observed in these animals but not enough to reverse iron deficiency anemia in post-gastrectomy rats.

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Section: Introductionmentioning

confidence: 99%

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

et al. 2018

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“…The patient underwent surgery, which removes or reduces gastric camera, can display physiological changes represented by dumping syndrome, lower protein digestion, reduced absorption of vitamin B12 and intestinal malabsorption. These changes contribute to the progressive deterioration of the nutritional status and may lead to malnutrition 3 17 26 28 .…”

Section: Introductionmentioning

confidence: 99%

Early Oral Re-Feeding on Oncology Patients Submitted to Gastrectomy for Gastric Cancer

Laffitte

Polakowski

Kato

2015

ABCD, arq. bras. cir. dig.

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Background: There is no advantage in maintaining patients on oral fasting after gastrointestinal elective resection. The early feeding up to 48 h can be beneficial, because it reduces infectious complications and hospital stay. Aim: Evaluate the evolution and tolerance of early oral diet in postoperative period after gastrectomy for gastric cancer. Methods: Anthropometric assessment was performed on the day of surgery, weight, height, body mass index and weight loss were measured. Acceptance of diet was evaluated as food intake (amount accepted) and gastrointestinal symptoms such as nausea, vomiting, constipation, diarrhea, abdominal distension, postoperative complications and hospital stay. Results: The sample consisted of 23 patients, 17 with partial gastrectomy and six with total gastrectomy. In the assessment of nutritional status 9% were malnourished, 54.5% normal weight, 9% overweight and 27.2% obese, but 54% had weight loss. There was good acceptance of the diet in 96,9% of the sample. Nausea and abdominal distension were present in 4,3% and 65.2% constipation. Surgical complications according to the Clavien scalle, 13% had grade V, 4.3% grade IIIA, 8.7% grade I and 73% did not have complications. The length of hospital stay was 5±2.2 days. Conclusion: Early postoperative re-feeding in total and partial gastrectomy was well tolerated by patients.

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“…In the early stages after gastrectomy, iron-deficiency anemia occurs because gastric acid plays an important role in small intestinal iron absorption through solubilization of dietary insoluble iron salts 14,17,23 .…”

Section: Introductionmentioning

confidence: 99%

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Santos¹,

Tsuboi²,

Araújo³

et al. 2011

ABCD, arq. bras. cir. dig.

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headings -Prebiotics. Gastrectomy. Iron. Anemia. Rats.abstRact -Background -The ingestion of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), leads to an increase in iron absorption and promotes recovery from anemia in gastrectomized rats. Aim -To study whether GOS + PDX stimulate iron absorption in gastrectomized and normals rats. Methods -Rats were laparotomized (sham-operated control) and partially gastrectomized (Billroth II) in groups of 20 each. Animals from both treatments were subsequently fed a control diet (AIN-93M) or the same diet supplemented with GOS and PDX (25 g/Kg of diet each) for eight weeks. They were divided into four subgroups, i.e., sham-operated and gastrectomized without GOS + PDX, sham-operated and gastrectomized with GOS + PDX. Two rats died during the experiment. All gastrectomized rats received an intramuscular injection of vitamin B-12 every two weeks. Hematocrit (HCT) and hemoglobin concentration (HGB) were measured at the start and on day 30 and 56 days after the start of feeding. On the final day of the study, total blood was collected for determination of serum iron concentration. Results -In the diet with GOS + PDX, iron excretion in feces was significantly lower than without the prebiotics. Apparent iron absorption and serum iron was higher in the GOS + PDX fed groups (both sham operated and gastrectomized) than in the non-GOS + PDX fed groups. The HCT and HGB concentrations were significantly lower in gastrectomized rats than in the control group, however, GOS + PDX feeding improved HGB levels in this group. ConclusionThe association of the GOS + PDX increase absorption of iron in sham-operated and gastrectomized rats and still prevent postgastrectomy anemia.Resumo -Racional -Ratos gastrectomizados desenvolvem anemia, e a ingestão de galactooligossacarídeo (GOS) e a polidextrose (PDX) aumenta a absorção de ferro e promove a recuperação da anemia em ratos com deficiência de ferro. Objetivo -Avaliar se GOS e PDX estimulam a absorção de ferro em ratos gastrectomizados e normais. Métodos -Os ratos foram laparotomizadas (controle falso-operado) e parcialmente gastrectomizados (Billroth II) em grupos de 20 animais. Os animais de ambos os tratamentos foram posteriormente submetidos à dieta controle (AIN-93M) ou a mesma dieta suplementada com GOS e PDX (25 g/kg de dieta cada) durante oito semanas e divididos em quatro subgrupos: sham-operados e gastrectomizados sem GOS e PDX, sham-operados e gastrectomizados com GOS e PDX. Dois animais morreram durante o experimento. Todos os ratos gastrectomizados receberam uma injeção intramuscular de vitamina B-12 a cada duas semanas. Hematócrito (HCT) e concentração de hemoglobina (HGB) foram dosados no início e nos dias 30 e 56 dias após o início da alimentação. No último dia do estudo, o sangue total foi coletado para determinação da concentração de ferro sérico. Resultados -Na dieta com GOS e PDX a excreção de ferro nas fezes foi significativamente menor do que no grupo sem prebióticos. Absorção aparente de ferro e ferro sé...

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Causas da desnutrição pós-gastrectomia

Abstract: Body-weight loss and anemia are the protein-energy malnutrition findings often found in these patients whose severity and lasting depend upon the type of surgery, post-surgery length and received nutritional care, being strongly recommended a supervisioned dietary care.

Cited by 23 publications

References 12 publications

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

Early Oral Re-Feeding on Oncology Patients Submitted to Gastrectomy for Gastric Cancer

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

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