Hepatitis c virus investigation in pemphigus foliaceus (fogo selvagem) patients

Rosa, Heitor; Martins, Regina Maria Bringel; Vanderborght, Bart

doi:10.1590/s0004-28032000000100009

Cited by 3 publications

(3 citation statements)

References 10 publications

(10 reference statements)

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“…11 However, there are also opposing results: Rosa et al did not find any association between HCV infection and pemphigus in 126 patients with fogo selvage, in their study group. 10 In terms of our findings, although the prevalence of HCV infection was 4% in the control group, none of our 62 pemphigus patients had HCV infection. Nevertheless, the prevalence of HBV infection in our pemphigus patients was 4.3%, while it was 2 % in the control group.…”

Section: Discussioncontrasting

confidence: 50%

“…8 The prevalence of HBV infection in anti-HCV-positive pemphigus foliaceus patients was also found to be considerable. 10 Sagi et al found that the frequency of HBV, HCV, H. pylori, T. gondii, T. pallidum and CMV was significantly higher than in the control group in pemphigus and bullous pemphigoid patients. 9 In accordance with these results, a pemphigus case has been reported after a hepatitis B vaccination.…”

Section: Discussionmentioning

confidence: 98%

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Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Demirci

Aydıngöz

Mansur

et al. 2014

An. Bras. Dermatol.

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BACKGROUND Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated. OBJECTIVESTo investigate the relationship between pemphigus and the hepatitis B and C virus infections. METHODSThis retrospective study included 62 patients with pemphigus and 50 healthy controls of matching ages and genders. The control group included relatives who accompanied the orthopedic patients to the hospital but had no history of systemic and/or autoimmune diseases. RESULTSThe group of patients with pemphigus was composed of 43 (69.3%) females and 19 (29.7%) males, and the mean age was 48.08 ± 15.38. The hepatitis C virus antibody was negative in all of the patients. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), or both, were studied in 44 of the 62 patients. Two (4.3%) of these patients were positive for HBsAg and found to have HBV infection. Fourteen of them were HBsAb positive. Two (4%) of the 50 control subjects showed hepatitis C virus antibody positivity, while only 1 (2%) patient with pemphigus displayed HBsAg positivity. There was no statistically significant difference between the two groups for hepatitis B and C virus infections. CONCLUSIONSThis study does not support an association between pemphigus and hepatitis B and/or C virus infections.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 98%

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Demirci

Aydıngöz

Mansur

et al. 2014

An. Bras. Dermatol.

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“…Data concerning HCV infection in pemphigus show some discrepancies. In fact, Rosa et al . did not detect the presence of anti‐HCV in a cohort of 129 patients with fogo selvagem.…”

Section: Prevalence Of Serological Markers Of Hepatitis B Virus Infecmentioning

confidence: 99%

Human herpesvirus‐8 and hepatitis B and C virus infections in pemphigus

et al. 2014

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Is there an association between pemphigus and hepatitis viruses? A population-based large-scale study

et al. 2017

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The association between pemphigus and hepatitis viruses has not been investigated sufficiently and remains unclear. Our objective was to assess the association between pemphigus and chronic hepatitis B (HBV) and hepatitis C (HCV) infections using a large-scale real-life computerized database. This study was conducted as a cross-sectional study utilizing the database of Clalit Health Services. The proportion of chronic HBV and HCV infections was compared between patients diagnosed with pemphigus and age-, sex-, and ethnicity-matched controls. Univariate analysis was performed using chi-square and Student's t test, and multivariate analysis was performed using a logistic regression model. A total of 1985 pemphigus patients and 9874 controls were enrolled in the study. The prevalence of HBV chronic infection in patients with pemphigus was significantly higher than in control subjects (1.2 vs. 0.6%, respectively, p = 0.008). The prevalence rate of HCV carrier state was comparable between pemphigus patients and control subjects (1.1 vs. 1.0, respectively, p = 0.732). A multivariate analysis revealed a significant association between pemphigus and HBV with a multivariate odds ratio (OR) of 1.9 [95% confidence interval (CI), 1.2-3.90], whereas no association between pemphigus and HCV was identified (OR 1.1, 95% CI, 0.7-1.7). In conclusion, patients with pemphigus have a greater proportion of chronic HBV but not HCV infection relative to matched controls.

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Hepatitis c virus investigation in pemphigus foliaceus (fogo selvagem) patients

Cited by 3 publications

References 10 publications

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Human herpesvirus‐8 and hepatitis B and C virus infections in pemphigus

Is there an association between pemphigus and hepatitis viruses? A population-based large-scale study

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