Probiotic, Prebiotic or Symbiotic Supplementation Impacts on Intestinal Microbiota in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review

Abstract

Background Supplementation with probiotics, prebiotics and symbiotics has shown positive effects on clinical markers and risk factors for non-alcoholic fatty liver disease (NAFLD). Objective To evaluate the effect of supplementation with probiotic, prebiotic or symbiotic on intestinal microbiota in NAFLD patients. Methods Two investigators conducted independently search for articles in the Medline databases, via PubMed, Web of Science, Embase, Scopus, Lilacs, Central Cochrane Library, Clinical Trials.gov and on the Ovid platform for the gray literature search. Results A total of 3,423 papers were identified by searching the electronic databases; 1,560 of them were duplicate and they were excluded; 1,825 articles were excluded after reading the title and abstract. A total of 39 articles were select to reading, however only four articles met the eligibility criteria to include in this systematic review. Three of the included studies that used prebiotic or symbiotic supplementation showed that after the intervention there were changes in the intestinal microbiota pattern. Only in one study such changes were not observed. A high risk of bias was observed in most assessments. Conclusion Although there is a possible change in the gut microbiota of individuals with NAFLD after supplementation with symbiotics or prebiotics, a clinical indication as part of NAFLD treatment is not yet possible.

The Effects of Probiotics, Prebiotics and Synbiotics in Non-Alcoholic Fat Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review

“…Other reviews evaluated the effectiveness of prebiotics or probiotics alone [ 24 , 25 , 26 , 27 ]. Only two reviews compared the effects of probiotics, prebiotics and synbiotics on liver enzymes, but not on other risk factors associated with NAFDL and NASH [ 23 , 28 ]. Souza et al [ 28 ] also performed a review comparing the effects of probiotics, prebiotics and synbiotics on NAFLD.…”

“…Only two reviews compared the effects of probiotics, prebiotics and synbiotics on liver enzymes, but not on other risk factors associated with NAFDL and NASH [ 23 , 28 ]. Souza et al [ 28 ] also performed a review comparing the effects of probiotics, prebiotics and synbiotics on NAFLD. Nevertheless, only four trials were included in the review.…”

A Importância Dos Probióticos Para a Saúde

“…Eles ajudam a criar uma camada protetora entre parede intestinal e bolo alimentar, a impedir a constipação e a tratar diversos tipos de diarreia. Os probióticos também auxiliam os movimentos peristálticos,(SOUZA, 2022).Bactérias intestinais podem produzir neurotransmissores como acetilcolina, GABA e serotonina. Os baixos níveis de serotonina estão associados a um maior risco de problemas de sono e depressão e estudos o intuito de repor a microbiota intestinal.…”