Classical Serological Markers in Pediatric Inflammatory Bowel Disease in Brazil

Rodrigues, M.L.V.; Bueno, Cleonice; Lomazi, Elizete Aparecida; Fernandes, Maria Inez Machado; Neufeld, Clarice B.; D’Amico, Maria Fernanda M.

doi:10.1590/s0004-2803.202100000-89

Arq. Gastroenterol.

2021

DOI: 10.1590/s0004-2803.202100000-89

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Classical Serological Markers in Pediatric Inflammatory Bowel Disease in Brazil

M.L.V. Rodrigues

Cleonice Bueno

Elizete Aparecida Lomazi

et al.

Abstract: BACKGROUND: Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCAs) have long been used to differentiate between Crohn’s disease (CD) and ulcerative colitis (UC), more recently having been used as prognostic indicators. OBJECTIVE: To determine the diagnostic accuracy of serological markers in the identification of pediatric CD and UC in Sao Paulo, Brazil, as well as to correlate those markers with characteristics demographic and clinical of these two … Show more

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Publications in Inflammatory Bowel Diseases in the Archives of Gastroenterology

Saad-Hossne

2021

Arq. Gastroenterol.

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A brief historical analysis of inflammatory bowel diseases (IBD) allows us to visualize a new scenario, either in incidence and prevalence, combined with new concepts, new strategies and consequently new challenges, which are more defying in children and adolescents in terms of diagnosis and treatment. As we know, IBD still has no cure and its treatment and control will be permanent, associated with that there is the real necessity for surgical treatment, whether it is due to complications, such as failure of clinical treatment or due to the more aggressive course of the pediatric disease. Likewise, delayed puberty and compromised growth have definite and devastating impacts on this population.We have observed an increase in the number of publications with international and national data about the epidemiology of IBD. In a deeper and more detailed reading, we observe that in the international scenario, especially in developed countries, there is a certain trend towards the stabilization of its incidence (1) . In developing countries, such as Brazil, there is an increase in incidence and prevalence in young adults, adolescents and children; when comparing the two diseases, ulcerative colitis (UC) seems to be more common in preschool children, while CD is more prevalent in older children (1) .The largest epidemiological study ever carried out on national data, in which more than 210,000 patients were analyzed, revealed an increase in the prevalence of both IBD, but the increase in incidence was only observed in UC, and in the same way there was a predominance of UC when compared to Crohn's disease (CD) (2) . These data differ from other national studies, in which there is a predominance of CD in relation to UC, as in one of the articles in this issue (3) , which was carried out in a reference center for IBD in the city of Campinas (São Paulo). The authors emphasize that the increase in incidence and prevalence rates is more evident in recently industrialized countries, specifically in Asia, Africa, Eastern Europe and Latin America. They observed that the patients were young, with no gender predominance, and that there was a higher frequency of patients with CD (66.6%). Most of them (85.4%) were

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Publications in Inflammatory Bowel Diseases in the Archives of Gastroenterology

Saad-Hossne

2021

Arq. Gastroenterol.

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Diagnostic significance of antineutrophil cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in patients with inflammatory bowel disease

Khalitova,

Zhestkov,

Myakisheva

2023

General Physician

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The study involved 100 patients with inflammatory bowel disease: 65 patients with ulcerative colitis and 35 patients with Crohn's disease. The control group consisted of 50 participants. The mean age of the patients was 43.7±18.4 years. The diagnosis of UC or CD was established on the basis of clinical, laboratory, endoscopic, and histopathological results in accordance with the IBD diagnostic criteria. All participants underwent blood serum tests: IgA and IgG ASCA, p-ANCA by ELISA. Results. P-ANCA was significantly more common in the group of the patients with UC. 60 % of the patients tested positive for at least one antigen. The highest prevalence of p-ANCA was observed against lactoferrin, elastase, and proteinase 3. The occurrence of antibodies to ASCA was observed in 80 % of the patients with CD and in 15 % of the patients with UC. The proportion of the patients with a positive test result for IgA ASCA markers (72 %), IgG ASCA (57 %), and IgG / IgA ASCA (60 %) was significantly higher in the CD group than in the patients with UC and the control group (P<0.001). In the CD group, the proportion of the patients who tested positive for IgA ASCA was significantly higher in those after surgery compared to those who did not have surgical interventions. Conclusions. The most informative serological marker for UC verification used for differential diagnosis with CD are p-ANCA. The study revealed significantly more frequent localization of lesions within the colon and prevalence among young people in the patients with CD and with a positive ASCA result. A combination of ANCA and ASCA tests appears to be a good option for IBD laboratory diagnosis.

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Classical Serological Markers in Pediatric Inflammatory Bowel Disease in Brazil

Cited by 2 publications

References 34 publications

Publications in Inflammatory Bowel Diseases in the Archives of Gastroenterology

Publications in Inflammatory Bowel Diseases in the Archives of Gastroenterology

Diagnostic significance of antineutrophil cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in patients with inflammatory bowel disease

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