The H. Pylori-Related Virulence Factor Caga Influences the Expression of Chemokines Cxcl10, Ccl17, Ccl20, Ccl22, and Their Receptors by Peripheral Blood Mononuclear Cells From Peptic Ulcer Patients
Abstract:BACKGROUND: During the Helicobacter pylori (HP) infection, the infiltration of the leukocytes into stomach mucosa is directed by locally produced chemokines that play a decisive role in infection outcome. The CagA is the most potent virulence factor of HP, so that the infection with CagA + strains is associated with more severe complications than infection with CagA - HP. OBJECTIVE: The aim was to determine the expression of chemokines CXCL10, CCL17, CCL20 and CCL22, and their receptors by CagA + HP- and… Show more
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