Reproductive Aspects in Brazilian Celiac Women

Kotze, Lorete Maria da Silva; Mallmann, Andyara; Miecznikowski, Rebeca C; Chrisostomo, Kadija Rahal; Kotze, Luiz Roberto; Nisihara, Renato

doi:10.1590/s0004-2803.202000000-18

Cited by 8 publications

(6 citation statements)

References 10 publications

(13 reference statements)

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“…In our study, psychiatric and neurological symptoms, which are common in this age group, could be part of the CD spectrum of manifestations, similar to those described by other authors 16,17 The risk of complications is higher in patients with late recognition of CD because gluten testing is more time-consuming 2 . We observed that anemia and bone disorders were more frequent.…”

Section: Gastrointestinal Segment N (%)supporting

confidence: 89%

Clinical profile of Brazilian patients aged over 50 years at the diagnosis of celiac disease

Kotze

Arcie

et al. 2023

Rev. Assoc. Med. Bras.

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Section: Gastrointestinal Segment N (%)supporting

confidence: 89%

Clinical profile of Brazilian patients aged over 50 years at the diagnosis of celiac disease

Kotze

Arcie

et al. 2023

Rev. Assoc. Med. Bras.

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“…Seven studies (5 cohorts) [ 34 , 35 , 37 , 40 - 42 , 44 ] were analyzed, including 7978 pregnant women with CD and 78,241 non-CD pregnant women; SA was detected in 11.5% (n=920) vs. 9.2% (n=7202), respectively. A statistically significant positive correlation was found between the risk for SA and CD (RR 1.35, 95%CI 1.10-1.65).…”

Section: Resultsmentioning

confidence: 99%

Adverse pregnancy outcomes in women with celiac disease: a systematic review and meta-analysis

Arvanitakis

Siargkas

Dagklis

et al. 2022

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Background The aim of this meta-analysis was to evaluate the risk of adverse pregnancy outcomes in women affected with celiac disease (CD), and to further estimate the impact of early disease diagnosis and subsequent adherence to a gluten-free diet (GFD) on obstetric complications. Methods A systematic search for English language observational studies was conducted in Medline, Scopus, and the Cochrane Library, from inception till April 2022, to identify relevant studies reporting on the incidence of adverse pregnancy outcomes in women with CD. Odds ratios (OR) and relative risks (RR) with 95% confidence intervals (CIs) were used to combine data from case-control and cohort studies, respectively. The quality of the included studies was assessed using the Newcastle-Ottawa scale. Results In total, 14 cohort and 4 case-control studies were included and our analysis demonstrated that the risk for spontaneous abortion (RR 1.35, 95%CI 1.10-1.65), fetal growth restriction (RR 1.68, 95%CI 1.34-2.10), stillbirth (RR 1.57, 95%CI 1.17-2.10), preterm delivery (RR 1.29, 95%CI 1.12-1.49), cesarean delivery (RR 1.10, 95%CI 1.03-1.16) and lower mean birthweight (mean difference -176.08, 95%CI -265.79 to -86.38) was significantly higher in pregnant women with CD. The subgroup analysis demonstrated that only undiagnosed CD increased risk for fetal growth restriction, stillbirth, preterm delivery and lower mean birthweight, whereas early diagnosis of CD was not linked to any adverse pregnancy outcomes. Conclusions Undiagnosed CD is associated with a higher risk of adverse pregnancy outcomes. Early CD diagnosis and appropriate management with GFD may ameliorate these associations.

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“…These include the aforementioned iron deficiency anemia, delayed menarche, decreased AMH levels or a family history of CD [1,12,20,21]. At the moment it seems unreasonable to perform screening tests in all patients diagnosed with infertility, but for patients with one of the above-mentioned ones, it is worth considering.…”

Section: Discussionmentioning

confidence: 99%

“…In literature some authors point out a link between untreated CD and delayed menarche [20] and early menopause [7]. A shorter reproductive period is a consequence.…”

Section: Celiac Disease and Fertilitymentioning

confidence: 99%