[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

Abstract

BACKGROUND: In Brazil, particularly in the underdeveloped localities, the prevalence of Helicobacter pylori (H. pylori) infections can range up to 90%. These rates are higher in older individuals and vary by country region. H. pylori infections are linked to the development of gastric pathologies, namely mild to moderate gastritis, gastroenteritis, peptic ulcer, intestinal metaplasia, and gastric cancer. In 1994, this organism was classified by the International Agency for Research on Cancer (IARC) as pertaining to the Group 1 carcinogen for gastric adenocarcinoma etiology. Gastric cancer represents a significant public health problem, being the fourth most common malignant tumor and the second largest cause of cancer-related deaths. OBJECTIVE: To investigate the prevalence of H. pylori infection in dyspeptic patients and determine the link between clinical risk factors and gastric adenocarcinoma diagnosis. METHODS: Polymerase chain reaction (PCR) analysis was employed for molecular diagnosis of gastric tissue biopsies collected from 113 dyspeptic patients at the University Hospital of Federal University of Goiás. Molecular analyses allowed the identification of H. pylori infections. Furthermore, histopathological examinations were performed to determine the clinical risks of developing gastric malignancies. RESULTS: The test results identified 69 individuals older than 44 years, from 75 (66.4%) positive H. pylori infection samples. The prevalence of gastric adenocarcinoma in this study was 1.3%. Among the infected patients, six (8.2%) had high risk, and 67 (91.8%) had a low risk of developing gastric cancer (P<0.05). CONCLUSION: This study shows a high prevalence of H. pylori infection and identifies its contribution to gastric inflammations, which in the long term are manifested in high-risk clinical factors for the development of gastric adenocarcinoma.

Screening for the prevalence of Helicobacter pylori infection among dyspeptic patients using simple fecal antigen and serum antibody diagnostic methods at Mukalla city Hospitals, Hadhramout, Yemen

“…The data were confirmed by multivariate logistic regression analysis. Similar results of other studies revealed that H. pylori infection was associated with dyspepsia (Misganaw and Abera, 2017;Tameshkel et al, 2018;Borges et al, 2019;Mabeku et al, 2020). Other study showed the predictor of seroprevalence H. pylori was found to be epigastric pain (Hamrah et al, 2017).…”

Predicting Gastric Intestinal Metaplasia in a High-Risk Population

“…Several of the risk factors in this study were associated with increased odds of GIM. H. pylori, a carcinogen, is strongly associated with GIM [15,[25][26][27][28][29][30]. There was a higher percentage of GIM with H. pylori infection (14.4% vs. 5.6%) in this study.…”

Dietary habits and Helicobacter pylori infection: is there an association?

“…2 In Brazil, the prevalence is heterogeneous in different regions, with proportions of 31.7%, 61.1%, and 91% in the Southeast, Midwest, and North regions, respectively. 3,4,6 The prevalence of infection depends on different factors, and it is necessary to consider that these values may have been influenced by the living conditions of the population, different diagnostic methods, genetic characteristics of patients and bacteria, and lifestyle habits, among others.…”