Early Drain Fluid Amylase Is Useful to Predict Pancreatic Fistula After Pancreatoduodenectomy: Lessons Learned From a Southern Brazilian Center

Teixeira, Uirá Fernandes; Rodrigues, Pablo Duarte; Goldoni, Marcos Bertozzi; Sampaio, José Artur; Fontes, Paulo Roberto Ott; Waechter, Fábio Luiz

doi:10.1590/s0004-2803.201800000-28

Cited by 6 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This relationship between DFA concentration and salivary fistula development was consistent with research by Larsen et al [6] which showed an upward trend in DFA concentration with early fistulisation. DFA concentration and perioperative albumin ratio has been reported to be an effective predictor of pancreatic fistula development after pancreatomy [7][8][9], also allowing an assessment for the earlier removal of the drain [10]. We speculate that the reason for the association between DFA concentration and salivary fistula development may be as follows.…”

Section: Discussionmentioning

confidence: 88%

Drain fluid amylase as a predictor of postoperative salivary fistula in cases with benign parotid tumours

Zhang

Peng

et al. 2020

BMC Oral Health

View full text Add to dashboard Cite

Background Late diagnosis of a salivary fistula increases the risk of wound infection and scarring. The purpose of the present study was to identify a quantitative predictor of postoperative salivary fistula for cases treated with surgery. Methods Demographic, intraoperative and postoperative parameters for 57 cases that received surgery for benign parotid tumours were recorded from June 2017 to June 2018, of which 18 cases developed salivary fistulas. These data were analysed using univariate and binary logistic regression analyses as well as receiver operating curve analysis. Results Drain fluid amylase concentration was positively correlated with salivary fistula development (p < 0.001), with an odds ratio of 1.14 for a 1 KU/L increase in concentration and an optimal receiver operating curve cut-off value of 51,100 U/L for predicting salivary fistula development. Cases wherein the parotid–masseteric fascia remained intact were associated with a lower risk of salivary fistula development (p = 0.006). Conclusion Drain fluid amylase concentration may be a valuable predictor of postoperative salivary fistula in cases with benign parotid tumours.

show abstract

Section: Discussionmentioning

confidence: 88%

Drain fluid amylase as a predictor of postoperative salivary fistula in cases with benign parotid tumours

Zhang

Peng

et al. 2020

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…Median drain amylase levels post-pancreatoduodenectomy have been observed as significantly higher in CR-POPF patients[ 110 ] on POD1[ 52 ], POD2[ 57 ] and POD3[ 69 ]. Similarly, Moskovic et al [ 111 ] found median drain amylase concentration post-pancreatectomy to be significantly elevated on PODs 1-6 in CR-POPF patients.…”

Section: Introductionmentioning

confidence: 99%

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review

Rykina-Tameeva¹,

Samra²,

Sahni³

et al. 2022

World J Gastrointest Surg

View full text Add to dashboard Cite

Clinically relevant postoperative pancreatic fistula (CR-POPF) has continued to compromise patient recovery post-pancreatectomy despite decades of research seeking to improve risk prediction and diagnosis. The current diagnostic criteria for CR-POPF requires elevated drain fluid amylase to present alongside POPF-related complications including infection, haemorrhage and organ failure. These worrying sequelae necessitate earlier and easily obtainable biomarkers capable of reflecting evolving CR-POPF. Drain fluid has recently emerged as a promising source of biomarkers as it is derived from the pancreas and hence, capable of reflecting its postoperative condition. The present review aims to summarise the current knowledge of CR-POPF drain fluid biomarkers and identify gaps in the field to invigorate future research in this critical area of clinical need. These findings may provide robust diagnostic alternatives for CR-POPF and hence, to clarify their clinical utility require further reports detailing their diagnostic and/or predictive accuracy.

show abstract

“…The drain fluid amylase of first postoperative day could be more helpful on prediction of those patients with pancreatic leakage, and the level of drain fluid amylase on first postoperative day higher than 1300 U/L was a risk factor of pancreatic fistula. The diagnostic value and suggested cut-off levels of drain fluid amylase Day 1 in projection the postoperative pancreatic leakage will have to be validated by multicenter prospective studies (5).On the other hand, a pancreatic fistula after splenectomy deserves so much attention due to both increase in the morbidity and mortality rate and for the cost and need for resources to treat the affected patients(6). Furthermore, these studies to predict as soon as possible in the postoperative course on patients who are more likely to develop this complication, as we can able to predict those which could be treated in enhanced recovery pathways(7).Amylase levels of the drain fluid on postoperative first day enables to predict occurrence and severity of pancreatic fistula after splenopancreaticsurgery (8).…”

mentioning

confidence: 99%

Are Drain Fluid Amylase Levels Helpful on Secreening Pancreatic Fistula Secondary to Pancreatic Injury During Emergency Splenectomy?

Yıldız

2020

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Objective: Splenectomy is a major surgical intervention that brings several complications as well as saving life in the surgical treatment of blunt/penetrating spleen trauma. Although it is a highly standardized procedure in terms of the surgical technique used, pancreatic tail injuries can also be observed, especially during dissection and ligation of the splenic hilum. In this study, we investigated the possible helpful effects of the amylase levels of serum and drainage fluid when there was suspicion for pancreatic injury during splenic hilum dissection.

show abstract

Early Drain Fluid Amylase Is Useful to Predict Pancreatic Fistula After Pancreatoduodenectomy: Lessons Learned From a Southern Brazilian Center

Abstract: Early drain fluid amylase value is a useful test to stratify patients in relation to the risk of developing pancreatic fistula after pancreatoduodenectomies, in addition to correlate with the severity of this complication.

Cited by 6 publications

References 14 publications

Drain fluid amylase as a predictor of postoperative salivary fistula in cases with benign parotid tumours

Drain fluid amylase as a predictor of postoperative salivary fistula in cases with benign parotid tumours

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review

Are Drain Fluid Amylase Levels Helpful on Secreening Pancreatic Fistula Secondary to Pancreatic Injury During Emergency Splenectomy?

Contact Info

Product

Resources

About