Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease

Mahdi, Batool Mutar; Hasan, Riyadh Mohamad; Salih, Wafaa Hazim

doi:10.1590/s0004-2803.2017v54n1-08

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…There is a racial difference in GERD disease prevalence due to presence of many genes that affect the disease development. 17,18 Mahdi et al, 19 reported that HLA-DRB1 *15:01 had an association with GERD patients infected with H. pylori. Regarding recombination that is most commonly occurs in or around genes and haplotyoe structure strongly affects synapsis will occur that facilitates subsequent recombination events to occur.…”

Section: Discussionmentioning

confidence: 99%

“…7 One study found that there is an association between HLA-DRB1 *15:01 and GERD in patients with H. pylori positive infection. 8 Other study demonstrated that HLA B7 may increased susceptibility for Barrett's oesophagus. 9 HLA-DR expression is found in the oesophageal tissue of patients with ongoing inflammation in the lamina propria and submucosa of the oesophageal as a result of cytokine release.…”

Section: Introductionmentioning

confidence: 97%

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Role of human leukocyte antigens DRB1-DQB1 haplotype in the susceptibility to gastroesophageal reflux disease

Mahdi

Hasan

Hazim

2018

Gastroenterol Insights

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Gastro oesophageal reflux disease is due to involuntary gastric contents reflux into the esophagus from stomach, causing heartburn and acid regurgitation symptoms. Genetic and environmental factors are important factors in the causation of disease. Human Leukocyte antigens considered as an excellent marker for population genetics analysis and disease association. This study aimed to investigate the association between HLA-DRB1-DQB1 haplotype that inherited in linkage and its association with gastro oesophageal reflux disease (GERD). Patients and healthy controls were prospectively recruited from gastrocolonoscope unit at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January and July 2016. Forty Iraqi Arab Muslims patients with a history of heartburn and dyspepsia compared with 100 Iraqi Arab Muslims control. All study patients and control group underwent upper gastroesophageal endoscope examination and HLA-DRB1 and HLA-DQB1 genotype were done using sequence spesific oligonucleotide primer to both groups. The frequencies of two haplotype HLA-DRB1⁄03-DQB1⁄03 and HLADRB1⁄ 13-DQB1⁄06 were significantly higher in patients with GERD while haplotype HLA-DRB1⁄03-DQB1⁄02 was significantly higher in control group. Sex had an effect in disease developing that haplotype HLADRB1⁄ 03-DQB1⁄03 was significantly more common in female patients that increased susceptibility to disease. This study identified that two haplotypes HLA-DRB1⁄03- DQB1⁄03 and HLA-DRB1⁄13- DQB1⁄06 leads to increased susceptibility to GERD and haplotype HLA-DRB1⁄03-DQB1⁄02 was protective against GERD development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Role of human leukocyte antigens DRB1-DQB1 haplotype in the susceptibility to gastroesophageal reflux disease

Mahdi

Hasan

Hazim

2018

Gastroenterol Insights

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Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis

Witarto,

Pramudito

et al. 2023

Sci Rep

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Erosive esophagitis (EE) is the part of gastroesophageal reflux disease (GERD) spectrum and may progress to esophageal adenocarcinoma. Due to its progressivity and unclear prevalence, we aim to identify the factors contributing in EE to decide the need for further examination. We performed a PRISMA 2020-based systematic search through PubMed and other resources up to June 2, 2022. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). The odds ratio (OR) of each factor and worldwide prevalence of EE were measured. There are 114 observational studies included with a total of 759,100 participants. Out of 29 factors, the significant risk factors are age ≥ 60 y.o. (OR 2.03 [1.81–2.28]), White/Caucasian (OR 1.67 [1.40–1.99]), unmarried (OR 1.08 [1.03–1.14]), having GERD ≥ 5 years (OR 1.27 [1.14–1.42]), general obesity (OR 1.78 [1.61–1.98]), central obesity (OR 1.29 [1.18–1.42]), diabetes mellitus (DM) (OR 1.24 [1.17–1.32]), hypertension (OR 1.16 [1.09–1.23]), dyslipidemia (OR 1.15 [1.06–1.24]), hypertriglyceridemia (OR 1.42 [1.29–1.57]), hiatal hernia (HH) (OR 4.07 [3.21–5.17]), and non-alcoholic fatty liver disease (NAFLD) (OR 1.26 [1.18–1.34]). However, H. pylori infection (OR 0.56 [0.48–0.66]) and atrophic gastritis (OR 0.51 [0.31–0.86]) are protective towards EE. This study demonstrates that age, ethnicity, unmarried, long-term GERD, metabolic diseases, HH, and NAFLD act as risk factors for EE, whereas H. pylori infection and atrophic gastritis act as protective factors. These findings may enable a better understanding of EE and increase greater awareness to address its growing burden.

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Analysis of the potential molecular mechanisms of asthma and gastroesophageal reflux disease

Chen,

Zhang,

Zheng

et al. 2024

Journal of Asthma

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Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease

Cited by 4 publications

References 24 publications

Role of human leukocyte antigens DRB1-DQB1 haplotype in the susceptibility to gastroesophageal reflux disease

Role of human leukocyte antigens DRB1-DQB1 haplotype in the susceptibility to gastroesophageal reflux disease

Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis

Analysis of the potential molecular mechanisms of asthma and gastroesophageal reflux disease

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