“…[222] Fatigue has been associated with disease severity, ascites, encephalopathy, level of physical activity, poor sleep quality, decreased quality of life, mood disturbance, anxiety, depression, and job performance in cirrhosis and with age, sex, diet, mental status, and personality type in general populations. [220,[223][224][225][226][227][228] The evaluation of fatigue should include a comprehensive assessment of other potential contributing factors, such as hypothyroidism, depression, adrenal insufficiency, anemia, vitamin deficiency, and medication side effects (e.g., beta-blockers). [222,226,229,230] Nonpharmacological management of fatigue includes education, recommendations about energy-conserving and -restoring activities, and referral to physical and occupational therapy.…”