Antisecretory Treatment for Pediatric Gastroesophageal Reflux Disease - A Systematic Review

Mattos, Ângelo Zambam de; Marchese, Gabriela Meirelles; Fonseca, Bárbara B; Kupski, Carlos; Machado, Marta Brenner

doi:10.1590/s0004-2803.201700000-42

Cited by 24 publications

(22 citation statements)

References 30 publications

(43 reference statements)

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“…Kedua artikel tersebut adalah penelitian kohort oleh Ruigomez dkk, 6 dan penelitian telaah sistematik oleh Mattos dkk. 7 Jurnal pertama adalah penelitian Ruigomez dkk 6 dengan melakukan kohort prospektif (level of evidence 2b) terhadap 8172 pasien yang mendapatkan terapi PPI dan 7905 pasien yang mendapatkan antagonis reseptor-H2 untuk pertama kalinya yang berobat pada pusat layanan primer di Inggris sejak Oktober 2009 dan September 2012. Penelitian ini bertujuan untuk membandingkan karakteristik pasien yang mendapatkan terapi dan luaran keamanan pasca pemberian terapi.…”

Section: Hasil Penelusuran Literaturunclassified

“…Penyakit refluks gastroesofageal memerlukan terapi secara medis terutama obat-obat yang menekan atau menghambat sekresi asam lambung. 7 Tata laksana yang efektif dan aman untuk mengatasi gejala dan tanda PRGE dapat dilakukan dengan tata laksana non-farmakologis, tata laksana farmakologis dan tata laksana pembedahan; dengan algoritma tata laksana terbagi dua, yaitu pada bayi dan anak. 4 Tata laksana non-farmakologis RPGE di antaranya thikening feeding, positioning, modifikasi gaya hidup seperti menghindari alkohol dan asap rokok dapat dilakukan.…”

Section: Pembahasanunclassified

See 1 more Smart Citation

Pemberian Proton Pump Inhibitor Dibandingkan dengan Antagonis Reseptor-H2 pada Anak dengan Penyakit Refluks Gastrointestinal

Dwipoerwantoro

Yulman

2019

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Latar belakang. Pada umumnya anak dengan penyakit gastroesofageal refluks (PRGE) diterapi dengan antagonis reseptor H2 (H2RA) atau inhibitor pompa proton (PPI). Keduanya merupakan obat yang tersering diresepkan pada PRGE anak, namun efikasi keduanya masih kontroversi.Tujuan. Untuk mengevaluasi penggunaan PPI dan H2RA pada anak dengan PRGE melalui telaah sajian kasus berbasis bukti.Metode. Pencarian literatur secara sistematik menggunakan instrumen pencari PUBMED, Cochrane, dan Google Scholar. Pencarian dibatasi pada literatur berbahasa Inggris, yang dipublikasi selama 15 tahun terakhir, dan usia pasien 0–18 tahun. Studi dianggap memenuhi syarat bila dilakukan secara randomized-controlled trials, mengevaluasi PPI dan/atau H2RA untuk pengobatan GERD anak. Studi yang hanya berupa abstrak, yang hanya mengevaluasi selain non-klinis, dan laporan kasus diekslusi.Hasil. Studi kohort oleh Ruigomez dkk mencakup 8172 pasien dengan PPI (24 pasien dengan esomeprazole dan 8148 pasien dengan PPI lainnya) dan 7905 dengan H2RA. Karakteristik dasar keduanya serupa, namun anak dengan PPI cenderung lebih tua usianya. Luaran terkait keselamatan sebanyak 92 hanya pada PPI selain esomeprazole. Mattos dkk memperoleh 735 literatur, 23 studi (1598 pasien yang dirandomisasi) yang diikutsertakan dalam review sistematik. Delapan studi membuktikan bahwa PPI dan H2RA cukup efektif mengatasi manifestasi tipikal GERD. Studi lain menunjukkan bahwa omeprazole lebih unggul dibandingkan rantidin dalam pengobatan manifestasi refluks ekstra esofageal.Kesimpulan. Inhibitor pompa proton (PPI) atau H2RA dapat digunakan untuk pengobatan GERD pada anak. Omeprazol lebih unggul dibandingkan ranitidine pada pengobatan manifestasi refluks ekstra esophageal.

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Section: Hasil Penelusuran Literaturunclassified

Section: Pembahasanunclassified

Pemberian Proton Pump Inhibitor Dibandingkan dengan Antagonis Reseptor-H2 pada Anak dengan Penyakit Refluks Gastrointestinal

Dwipoerwantoro

Yulman

2019

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“…Two topics of importance for child and adolescent health are addressed in this number of Arquivos de Gastroenterologia: histologic diagnosis of eosinophilic esophagitis (1) and antisecretory treatment of the gastroesophageal reflux disease (8) .…”

mentioning

confidence: 99%

“…The objective of the second article was to assess the role of the proton pump inhibitors and/or histamine H 2 receptor antagonists for the treatment of pediatric gastroesophageal reflux disease (8) . It is a systematic review that, by following the international recommendations, found 23 clinical trials on the theme.…”

mentioning

confidence: 99%

“…It was also observed that the proton pump inhibitors are more potent than the histamine H 2 receptor antagonists. They concluded that the proton pump inhibitors or histamine H 2 receptor antagonists may be used to treat children with gastroesophageal reflux disease, but not to treat asthma or unspecific symptoms (8) . An aspect that must be enhanced is the role of the proton pump inhibitors among infants with excessive crying which is one of the unspecific symptoms assigned to the gastroesophageal reflux disease.…”

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confidence: 99%

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Eosinophilic esophagitis and proton pump inhibitors: is there a new link?

Morais

2017

Arq. Gastroenterol.

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Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta‐Analyses

Meng

Chen

Zhang

et al. 2022

The Journal of Clinical Pharma

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Histamine H2 receptor antagonists (H2RAs) were widely used to inhibit gastric acid secretion, but its association with adverse events remains controversial and unclear. We conducted an umbrella review of meta-analyses to systematically assess the quality and credibility of the correlations between H2RA use with the risk of adverse outcomes through searching 4 major databases from inception to April 30, 2022. Forty-six individual metaanalyses were identified, including 29 meta-analyses of observation studies with 32 unique outcomes and 19 meta-analyses of randomized controlled trials with 3 unique outcomes for comparing the H2RA versus non-H2RA group. A Measurement Tool to Assess Systematic Reviews 2 rating for the included meta-analyses showed that 4 of 46 meta-analyses were assigned as high scores, 3 were assigned as "moderate," and 25 were assigned as low scores. Grading of Recommendations Assessment, Development and Evaluation assessment for combined results demonstrated that 6 outcomes were rated as "moderate," 9 outcomes were rated as "low," and 17 outcomes were rated as "very low." We confirmed significant associations of H2RA use with pneumonia, peritonitis, necrotizing enterocolitis, Clostridium difficile infection, liver cancer, gastric cancer, and hip fracture diseases. No associations for colorectal cancer, melanoma, kidney cancer, lung cancer, or common reproductive system cancer or renal, neurological, and cardiovascular system diseases were observed. We found a variety of evidence for the associations between H2RAs and adverse outcomes, which would give clinicians more positive guidance on prescription of H2RAs in clinical practice.

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Antisecretory Treatment for Pediatric Gastroesophageal Reflux Disease - A Systematic Review

Abstract: Proton pump inhibitors or histamine H2 receptor antagonists may be used to treat children with gastroesophageal reflux disease, but not to treat asthma or unspecific symptoms.

Cited by 24 publications

References 30 publications

Pemberian Proton Pump Inhibitor Dibandingkan dengan Antagonis Reseptor-H2 pada Anak dengan Penyakit Refluks Gastrointestinal

Pemberian Proton Pump Inhibitor Dibandingkan dengan Antagonis Reseptor-H2 pada Anak dengan Penyakit Refluks Gastrointestinal

Eosinophilic esophagitis and proton pump inhibitors: is there a new link?

Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta‐Analyses

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