Lugol’s Iodine Chromoendoscopy Versus Narrow Band Image Enhanced Endoscopy for the Detection of Esophageal Cancer in Patients With Stenosis Secondary to Caustic/Corrosive Agent Ingestion

Pennachi, Caterina Maria Pia Simoni; Amorim, Renato Bastos Pimenta; Guedes, Hugo Gonçalo; Kumbhari, Vivek; Moura, Eduardo Guimarães Hourneaux de

doi:10.1590/s0004-2803.201700000-19

Cited by 14 publications

(14 citation statements)

References 19 publications

(24 reference statements)

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“…[ 22 , 24 , 25 ] Comparison studies between LIS and NBI in the detection of EESCCs have revealed that NBI could provide comparable or even better diagnostic accuracy with greater convenience while avoiding the limitations inherent to the use of Lugol's solution as mentioned above. [ 8 – 10 , 26 ] Especially, the specificity of NBI with or without magnifying endoscopy was higher than that of LIS. [ 9 , 10 ]…”

Section: Discussionmentioning

confidence: 99%

Demarcation of early esophageal squamous cell carcinoma during endoscopic submucosal dissection

Shen

Geng

et al. 2021

Medicine

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Lugol's iodine staining (LIS) and narrow-band imaging (NBI) are currently the most common methods applied in demarcating early esophageal squamous cell carcinoma (EESCCs) during endoscopic submucosal dissection. The purpose of the present study was to investigate the effects on clinical outcomes in comparison between LIS and NBI for the demarcation of EESCCs during endoscopic submucosal dissection. This was a single-center, retrospective, cohort study. A total of 172 patients were involved. 109 patients received demarcation of the lesion by LIS and 63 patients by NBI. Data on baseline characteristics, clinical outcomes and follow-up information were collected for analyses. The mean diameter of the lesions was 3.9 ± 1.5 cm. R0 resection rate was 89.5%. The rate of total and in-hospital adverse events was 25.6% and 9.3%. The cumulative recurrence rate was 2.9% and 3-year disease-specific survival rate was 98.3%. Compared to patients of the LIS group, patients of the NBI group showed significantly shorter procedure time (44.8 ± 32.2 v.s. 57.0 ± 40.6, P = .044), lower rate of using of scopolamine butylbromide (19.0% vs 35.8%, P = 0.021), reduced number of clips used (1.3 ± 1.2 vs 1.8 ± 1.5, P = .017) and alleviated discomfort evaluated by visual analog system score after operation (4.7 ± 0.8 vs 5.5 ± 1.0, P < .001). There was no significant difference of R0 resection rate, margin status, adverse events, cumulative recurrence rate and 3-year disease-specific survival rate between the two groups. Demarcation of EESCCs by NBI could achieve comparable accuracy and clinical outcomes with more convenience and safety compared with demarcation by LIS.

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Section: Discussionmentioning

confidence: 99%

Demarcation of early esophageal squamous cell carcinoma during endoscopic submucosal dissection

Shen

Geng

et al. 2021

Medicine

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“…Five (13%) were noted with both techniques. Two (40%) of such lesions were confirmed as carcinomas on histopathological evaluation (Pennachi et al 2017).…”

Section: Presenting Signs and Symptomsmentioning

confidence: 92%

“…Zargar endoscopic classification score þ/> 2a Ingestion of strong (concentrated) acidic or alkaline chemical substances Elevated white blood cell count Decreased prothrombin ratio Thirty-eight Brazilian patients with a history of corrosive ingestions and esophageal stenosis >20 years previously were evaluated in an observational transitional trial, crosssectional study to assess whether Lugol's Iodine solution chemoendoscopy or Narrow Band Imaging were better for detecting of early esophageal cancer (Pennachi et al 2017). Nine suspicious lesions were found with Narrow Band Imaging and 14 were found with Lugol's solution chemoendoscopy.…”

Section: Presenting Signs and Symptomsmentioning

confidence: 99%

Corrosive substances ingestion: a review

Hall

Jacquemin²,

Henny³

et al. 2019

Critical Reviews in Toxicology

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Corrosive chemical substance ingestions are a major problem, especially in developing countries, but also in developed countries such as the United States, France, and Belgium. Ingestions may be deliberate as suicide attempts (mostly in adolescents and adults) or accidental (mostly in children). The results can be devastating in terms of individual suffering and disability, but also in terms of resource utilization and costs. In developing countries, outcomes may be worse because of limited medical/surgical resources. Common sequelae include gastrointestinal (GI) tract (esophagus, stomach, pylorus, and duodenum) stricture formation, GI tract perforation, and hemorrhage. Systemic effects may also occur, such as disseminated intravascular coagulation (DIC), multi-organ system failure, and sepsis. Various interventions in the acute phase to reduce the severity of injury have been attempted, but there are no large controlled clinical trials to demonstrate efficacy. Dilation therapy in various forms is commonly used for the treatment of strictures and a variety of surgical procedures including esophagectomy and delayed replacement may be required in severe corrosive injury cases.

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“…The detection of irregular mucosal, vascular patterns and abnormal blood vessels (disappearance of fine mucosal structure, micro vascular dilation and heterogeneity in shape of vessels) had a 94% sensitivity and 76% specificity for detection of high-grade BE and a sensitivity of 92.9% and 94.7% specificity for the diagnosis of early gastric and esophageal cancer [7][8][9][10]. Moreover, NBI ability to predict colonic polyp's histology has been reported [11][12][13].…”

Section: Narrow-band Imaging (Nbi)mentioning

confidence: 97%

New Technologies and Techniques in Gastrointestinal Endoscopy

Moura¹

2018

IOD

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Lugol’s Iodine Chromoendoscopy Versus Narrow Band Image Enhanced Endoscopy for the Detection of Esophageal Cancer in Patients With Stenosis Secondary to Caustic/Corrosive Agent Ingestion

Abstract: Narrow Band Imaging is an applicable option to detect and evaluate cancer in patients with caustic /corrosive stenosis compared to the Lugol´s solution chromoscopy.

Cited by 14 publications

References 19 publications

Demarcation of early esophageal squamous cell carcinoma during endoscopic submucosal dissection

Demarcation of early esophageal squamous cell carcinoma during endoscopic submucosal dissection

Corrosive substances ingestion: a review

New Technologies and Techniques in Gastrointestinal Endoscopy

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