Keratoprosthesis in the fight against corneal blindness in developing countries

Oliveira, Lauro Augusto de; Cade, Fabiano; Dohlman, Claes H.

doi:10.1590/s0004-27492011000100001

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…1 , 2 Keratoprosthesis (KPro) is indicated in cases of corneal blindness for which conventional treatment with penetrating keratoplasty (PK) has either failed or has a poor prognosis. 3 – 5 A consistent meta-analysis showed that over the intermediate-term postoperative follow-up period, patients receiving KPro are more likely to achieve improvement in their visual acuity and to retain this improvement than patients undergoing a repeated PK. 6 Much effort has been focused on improving the biocompatibility and clinical performance of KPro.…”

Section: Introductionmentioning

confidence: 99%

Titanium Powder 3D-Printing Technology for a Novel Keratoprosthesis in Alkali-Burned Rabbits

Magalhães

Alcântara

Gomes

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To evaluate the surgical technique, clinical performance, and biocompatibility of a novel keratoprosthesis (KPro) named KPro of Brazil (KoBra) in an alkali-burned rabbit model. Methods Two-piece three-dimensional-printed titanium powder and polymethyl methacrylate KPros were implanted into 14 alkali-burned corneas of 14 rabbits using an autologous full-thickness corneal graft as the KPro carrier. Rabbits were examined weekly for 12 months to evaluate retention and postoperative complications. Anterior segment optical coherence tomography (AS-OCT) and scanning electron microscopy (SEM) were performed at the end of the experiment to evaluate the relationship between the KoBra and the carrier graft. Results All surgeries were performed without intraoperative complications, and the immediate postoperative period was uneventful. In 12 eyes (85.7%), the implanted KPros integrated into the operated eyes and maintained clear optics without extrusion or further complications over 12 months. Two eyes presented late postoperative complications that progressed to KPro extrusion: one had a presumed infectious keratitis, and the other had sterile stromal necrosis. AS-OCT demonstrated the correct relationship of the device and carrier graft in all remaining animals at the final follow-up. SEM findings indicate the integration of the porous structure of the back plate into the surrounding tissue. Conclusions Clinical evaluations, AS-OCT, and SEM findings indicate good biointegr-ation of the implanted device into the corneal carrier graft. KoBra has the advantage of using recipients’ own corneas as the prosthesis supporter, and its surgical procedure is relatively simple and safe. Translational Relevance Titanium three-dimensional-printed technology used in an animal limbal stem-cell deficiency model holds great promise for the treatment of corneal blindness in humans.

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Section: Introductionmentioning

confidence: 99%

Titanium Powder 3D-Printing Technology for a Novel Keratoprosthesis in Alkali-Burned Rabbits

Magalhães

Alcântara

Gomes

et al. 2022

Trans. Vis. Sci. Tech.

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“…This has become the most common procedure for handling cases where penetrating keratoplasty has failed. It is being used at a rate of approximately 1,200 per year worldwide [4,5].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients with Dohlman-Doane Type 1 Keratoprosthesis(Boston Kpro)

Kwitko¹

2015

J Clin Exp Ophthalmol

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Introduction:The aim of this study was to assess quality of life in patients undergoing implantation of a Dohlman keratoprosthesis.Materials and methods: Cross-sectional controlled, with patients undergoing implant Dohlman keratoprosthesis type I at the Hospital de Clinicas de Porto Alegre between September 2005 and May 2013. Two questionnaires of quality of life were administered in these patients SF-36 and VF-14. Furthermore, a retrospective patient charts analysis was performed.Results: Keratoprosthesis implant surgery was performed in 33 eyes of 26 patients. A statistically significant difference was found between groups (separated by visual acuity) for the questionnaire of visual acuity (p=0.01). In SF-36 domains, there were difference in general health (p=0.036), vitality (p=0.028) and mental health (p=0.037). On the Spearman correlation analysis, 5 of the 8 domains of the SF-36, correlated with visual questionnaire (VF-14), when analyzed for the entire sample. When we separated the analysis by subgroups (according to visual acuity), in the group of lowest visual acuity had only one domain correlation (mental health). In the group of best vision, the 5 domains remained with a positive association. Conclusion:Patients with greater visual acuity showed better results in the VF-14 responses, with a statistically significant difference between groups.

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Indications and Contraindications of Boston KPRO Types I and II

Robert

Harissi‐Dagher

2014

Keratoprostheses and Artificial Corneas

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Keratoprosthesis in the fight against corneal blindness in developing countries

Cited by 7 publications

References 13 publications

Titanium Powder 3D-Printing Technology for a Novel Keratoprosthesis in Alkali-Burned Rabbits

Titanium Powder 3D-Printing Technology for a Novel Keratoprosthesis in Alkali-Burned Rabbits

Quality of Life in Patients with Dohlman-Doane Type 1 Keratoprosthesis(Boston Kpro)

Indications and Contraindications of Boston KPRO Types I and II

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